Paranasal sinus disorder

This study compares a new biodegradable nasal dressing that slowly releases a steroid (mometasone furoate) to a standard steroid-releasing stent, both used after sinus surgery. About 110 adults with chronic sinusitis (with or without nasal polyps) will receive the new dressing in…

This phase 2 trial is testing a combination of two immunotherapy drugs, nivolumab and ipilimumab, in 798 people with over 50 types of rare cancers. The goal is to see if these drugs can shrink tumors by helping the immune system attack cancer cells. Participants receive the drugs…

This study tests whether online training and regular feedback reports can help doctors prescribe fewer antibiotics for common infections like ear infections, strep throat, sinusitis, and pneumonia in children. About 420 children aged 6 months to 12 years are included. The goal is…

This study is testing whether a precise form of radiation called proton therapy can control head and neck cancer after surgery as well as standard X-ray radiation, but with fewer side effects. About 174 adults with newly diagnosed head and neck cancer will receive either proton t…

This study tests a new treatment for chronic sinusitis, a long-lasting sinus infection that doesn't get better with standard care. Researchers will take healthy bacteria from a donor's sinuses and transfer them into the sinuses of 80 patients, after a special sinus wash. The goal…

This study tests whether digital tools can help people with allergic rhinitis (hay fever) better control their symptoms. About 240 adults will use a smartphone platform that tracks symptoms, sends reminders, and gives personalized advice. Researchers will compare their progress t…

This study tests two drugs, pembrolizumab and cabozantinib, in 36 people with head and neck cancer that has returned or spread and cannot be surgically removed. The goal is to see if the combination shrinks tumors and delays cancer growth. Participants receive both drugs intraven…

This study tests whether giving a probiotic (Saccharomyces boulardii) along with a common antibiotic can protect the gut bacteria of children aged 4 to 12 being treated for ear or sinus infections. The goal is to see if it reduces antibiotic-associated diarrhea and limits the spr…

This early study tests a new approach for people with chronic sinusitis that keeps coming back. A balloon coated with the drug paclitaxel is inflated in the nasal passages to deliver medication directly to the tissue. The goal is to see if it is safe and can reduce symptoms and t…

This study tests an investigational drug called 611 in 243 adults with chronic sinusitis and nasal polyps that haven't been well-controlled by other treatments. The goal is to see if 611 can shrink polyps and ease nasal congestion over 24 weeks. Participants receive either the dr…

This study tests an experimental drug called itepekimab in 66 adults with chronic sinusitis who have not improved with standard treatments. Participants receive either the drug or a placebo for 24 weeks. The goal is to see if itepekimab can reduce sinus inflammation and ease symp…

This study tests whether rinsing the nose with a xylitol solution can reduce sinus symptoms in adults with cystic fibrosis. Participants will use both xylitol and standard saline rinses at different times to compare effects. The goal is to see if xylitol, a natural sugar alcohol,…

This study compares three ways to manage the airway during sinus surgery: a laryngeal mask, a breathing tube, and a breathing tube with lidocaine to numb the throat. Researchers want to see which method causes the least coughing and helps patients wake up more calmly. The trial i…

This pilot study tests whether adding epinephrine to a standard nerve block (pterygopalatine ganglion block) reduces bleeding during functional endoscopic sinus surgery (FESS) in people with chronic rhinosinusitis. Eighty adults undergoing bilateral FESS will receive the nerve bl…

This pilot study tests whether a small procedure done in the doctor's office (called EPIC) can work as well as standard sinus surgery for people with chronic sinusitis and nasal polyps. The EPIC procedure is done under local anesthesia and has a shorter recovery time. The study o…

This study tracks 80 adults with different smell disorders (like total loss, partial loss, or distorted smell) plus healthy volunteers over one year. Researchers use brain scans, smell tests, and questionnaires to see how the brain changes and how smell loss impacts mood and dail…

This study looked at whether having more frequent contact with a clinician (at least once a week) improves satisfaction for people with long-lasting musculoskeletal conditions. Participants were split into two groups: one with standard contact and one with extra check-ins via tex…

This study aimed to find out how often chronic sinusitis occurs in children treated for head and neck cancer, and how it affects their quality of life. Researchers planned to compare these children to those treated for cancer elsewhere in the body using a questionnaire called SNO…

This study tests whether a Norwegian clinic (NSAC) helps people with common mental health issues or muscle pain return to work sooner. 2500 adults are split into three groups: one gets treatment quickly, one waits 10-14 weeks, and one gets a basic check-up. Researchers will track…

This study aims to develop a new way to measure how well the sinuses work in people with chronic sinusitis. About 30 adults with chronic sinusitis and a recent bacterial infection will take the drug ivacaftor. The main goal is to see if a special test can detect changes in sinus …

This study tracks 40 people with nasal polyps and severe asthma who are taking mepolizumab, a drug that reduces inflammation. Researchers collect nose, blood, and sputum samples before treatment and at 3, 6, and 12 months to see how the drug affects symptoms, nose bacteria, and g…

This project works to make sure children with common respiratory infections get the right antibiotics for the right amount of time. It involves over 259,000 kids across many clinics. The goal is to learn the best ways to help doctors follow antibiotic guidelines and reduce unnece…

This study investigates why some people develop chronic sinusitis with nasal polyps, focusing on how epigenetic changes and viruses might trigger the disease. Researchers will analyze tissue samples from 60 participants, including patients with active disease, those in remission,…

This study looks back at the medical records of about 4 million people who had physical or occupational therapy for muscle and joint problems. Researchers want to see if different ways of giving therapy lead to different results. No new treatments are tested—the goal is to learn …

This study aimed to see if a mobile monitoring tool could accurately identify surgical site infections (SSIs) in orthopedic surgery patients, compared to the usual manual review. The study was withdrawn before enrolling any participants, so no results are available. It was design…

This study was designed to see how chronic sinusitis affects the tiny hair-like cells (cilia) that help clear mucus from the nose. Researchers planned to use special glowing nano-sticks to measure how well these cells work. However, the study was withdrawn before any participants…

This study looks at the bacteria living in the nose and sinuses of people with chronic sinusitis, allergies, and healthy individuals. By analyzing tissue samples from 285 participants, researchers hope to identify which bacteria are linked to long-term inflammation. The goal is t…

This study looks at the genes of 1,200 adults to find out why some people get chronic sinusitis. Participants must have a CT scan showing either normal sinuses or sinus disease. The goal is to identify genetic variations linked to the condition, which could lead to better underst…

This study tests whether giving patients an information sheet during a doctor's visit for a respiratory infection (like bronchitis, sinusitis, or sore throat) can lower antibiotic prescribing and improve communication. About 1,100 adults in Danish general practices will either re…

This study is testing a tiny camera called micro OCT that can take detailed pictures of cells inside the lungs and nose. Researchers want to see if it works well in people with cystic fibrosis and other lung conditions. The goal is to eventually use this imaging to detect early d…

This study is testing a new web-based tool designed to help people with chronic sinusitis make better decisions about their treatment, including whether to have surgery. About 50 patients from USC clinics will use the tool or receive standard information. Researchers will measure…

This study aims to see if a simple, non-invasive breathing test can accurately measure the acidity (pH) in the airways, which is often abnormal in lung diseases. Researchers will compare results from this breath test with standard methods in 150 healthy volunteers and people with…