Lacrimal apparatus disorder

This study tests an experimental drug called IMVT-1402 in 180 adults with moderate to severe Sjögren's disease. Participants receive either the drug or a placebo as a weekly injection under the skin for 24 weeks. The goal is to see if the drug can reduce overall disease activity …

This early-phase study tests a personalized cell therapy (rapcabtagene autoleucel) in 27 adults with difficult-to-treat rheumatoid arthritis or severe Sjogren's disease. The treatment uses a patient's own immune cells, modified to target and calm the overactive immune system. The…

This phase 3 trial tests whether nipocalimab can safely reduce disease activity in adults with moderate to severe Sjogren's disease. About 655 participants receive either nipocalimab or a placebo, along with standard care, for 48 weeks. The main goal is to see if the drug improve…

This Phase 3 trial tests whether a disc made from donated human amnion membrane can help people with moderate to severe dry eye disease. The disc is placed on the eye and compared to standard care like lubricating drops and a bandage lens. The study will enroll 40 adults who have…

This phase 3 study tests the long-term safety of ianalumab in 612 people with Sjögren's syndrome who already completed a year of treatment in earlier trials. Participants receive ianalumab or placebo injections for up to several more years. The goal is to see if the drug remains …

This phase 3 study tests whether ianalumab, a biologic drug, can reduce disease activity and symptoms in people with active Sjogren's syndrome. About 506 adults with a recent diagnosis (within 7.5 years) and positive anti-Ro/SSA antibodies are randomly assigned to receive ianalum…

This early-phase trial tests a new cell therapy called BEN301 for several autoimmune diseases, including scleroderma and rheumatoid arthritis. The therapy uses specially engineered immune cells (CAR-Treg cells) to calm the overactive immune system. The study involves 24 adults an…

This study tests if a new 2mL auto-injector or pre-filled syringe delivers the same amount of the drug ianalumab into the body as the current 1mL syringe. About 155 adults with rheumatoid arthritis, Sjögren's disease, or lupus will receive the drug both ways to compare how much g…

This study planned to test a new cell therapy (CD19-BCMA CAR-T) for people with connective tissue diseases like lupus and rheumatoid arthritis. The goal was to see if it is safe and can control the disease. However, the study was withdrawn before enrolling any participants, so no…

This study tests whether using two eye drops together—Vevye (cyclosporine) and Flarex (a steroid)—can safely improve symptoms in adults with moderate to severe dry eye disease. Sixty participants will use Vevye twice daily and Flarex four times daily for one month. The goal is to…

This phase 3 trial tests whether efgartigimod, given as a shot under the skin, can reduce disease activity in adults with moderate-to-severe primary Sjögren's disease. About 631 participants will receive either the drug or a placebo for 48 weeks, with an option to continue treatm…

This phase 3 trial tests deucravacitinib, an anti-inflammatory pill, in 774 adults with active Sjögren's syndrome. Participants receive either the drug or a placebo for 52 weeks. The goal is to see if the drug reduces disease activity and improves symptoms like dryness and fatigu…

This Phase 2 trial tests whether sibeprenlimab, a biologic drug given as a shot every 4 weeks, can reduce disease activity and symptoms in people with Sjögren's disease. About 83 adults with moderate-to-active disease will receive either the drug or a placebo, added to their usua…

This early-phase trial is testing a CAR-T cell therapy called RD06-04 in 12 people with active autoimmune diseases like lupus, scleroderma, and vasculitis. The treatment involves reprogramming a patient's own immune cells to target and destroy faulty B cells. The main goal is to …

This early-phase trial planned to test a one-time infusion of genetically modified immune cells (CAR-T cells) targeting CD19 in people with several autoimmune diseases, including lupus and multiple sclerosis. The goal was to see if it was safe and could reduce harmful antibodies.…

This early-phase trial is testing the safety of tofacitinib (Xeljanz), a drug already used for rheumatoid arthritis, in 23 adults with mild-to-moderate Sjogren's syndrome. Participants take the drug or a placebo daily for 168 days. The goal is to see if the drug is safe and toler…

This study was designed to check the long-term safety of a new eye drop that combines two active ingredients (lifitegrast and perfluorohexyloctane) for people with dry eye disease. It was a follow-up for people who had already completed an earlier study. However, the trial was wi…

This study compares using cyclosporine eye drops alone versus combining them with absorbable punctal plugs for dry eye caused by Sjögren's syndrome. Thirty participants will receive the drops in both eyes and a plug in one eye to see if the combination improves symptoms better. T…

This study tests whether two specialized eye imaging devices—the LipiView II and Keratograph 5M—can detect changes in tear film stability after using Miebo eye drops in people with dry eye. Twenty adults with normal tear film will have their eyes measured before and at several ti…

This study tests the Shingrix vaccine in over 2,000 adults with autoimmune rheumatic diseases like rheumatoid arthritis and lupus, who are at higher risk for shingles. Researchers will compare vaccinated patients to unvaccinated ones to see if the vaccine is safe and triggers a s…

Researchers are testing an experimental eye drop called TJO-087 in adults with dry eye syndrome. The trial enrolls about 90 people who have dry eye symptoms and signs of corneal damage. Participants receive either TJO-087 or a placebo drop for 3 months. The main measure is whethe…

This study is testing two versions of Tears Naturale lubricating eye drops—one with preservatives and one without—in 120 people with mild to moderate dry eye disease. Participants will stop using their usual artificial tears and use only the study drops for the duration of the tr…

This study tests whether an oral supplement that targets gut bacteria can improve dry eye symptoms in adults with moderate evaporative dry eye disease. Over 8 weeks, 130 participants will take either the supplement or a placebo. The main goal is to see if symptoms, measured by a …

This study tests whether eye drops made from a patient's own platelet-rich plasma can improve dry eye symptoms. Participants with dry eye syndrome will receive either platelet-rich plasma drops or plasma drops without platelets. The trial measures changes in vision, tear film qua…

This pilot study tests whether a specific hands-on technique inside the mouth can increase tear production in healthy adults aged 18-45. Thirty volunteers will have their tears measured before and after the procedure, with follow-up visits at 2 days and 1 week. The goal is to see…

This study aimed to see if a saffron-based supplement called AffronEye® could improve dry eye symptoms in university staff and students. It planned to compare the supplement to a placebo over 84 days using eye tests and symptom questionnaires. However, the study was withdrawn bef…

This early-phase trial tests whether eye drops made from mesenchymal stem cells can safely relieve symptoms in 10 women aged 40-60 with dry eye disease that didn't improve with artificial tears. Participants use the drops twice daily for two weeks and are followed for three month…

This study compares using an anti-inflammatory eye drop (nepafenac) plus a lubricant versus a lubricant alone to treat watery eyes (epiphora) caused by narrowing of the tear duct opening. Researchers will measure changes in tear duct size and symptom severity in 68 Mexican adults…

This study tests a low-level light therapy mask for dry eye disease in people with Graves' eye disease who haven't improved with standard treatments. Thirty adults will receive either the real light therapy or a sham device. The goal is to see if the treatment improves tear film …

This study tests an experimental drug called dazodalibep in 434 adults with moderate-to-severe Sjögren's syndrome, an autoimmune disease causing dryness, fatigue, and pain. Participants receive either the drug or a placebo to see if it improves symptoms like dry eyes and mouth. T…

This study tests whether Acoltremon 0.003% eye drops can quickly relieve symptoms like burning, irritation, and blurriness in people with moderate-to-severe dry eye disease. Fifty adults will use the drops as directed and report their symptom changes over 28 days. The goal is to …

This study tests a red-light mask (low-level light therapy) for treating dry eye and meibomian gland disease in 15 children with severe symptoms. It compares the light mask to standard care (warm compresses and artificial tears). The goal is to see if the light mask improves glan…

This study tests whether applying menthol solution to the cheek can release vapors that stimulate cold sensors on the eye, triggering natural tear production. Thirty healthy adults will receive either menthol or a placebo on one cheek, and researchers will measure if tears overfl…

This study tests a device called Rexon-Eye that uses gentle electrical pulses to treat dry eye disease. Thirty adults aged 18 to 40 will receive either real or sham treatment once a week for four weeks. Researchers will check if symptoms improve and analyze tear samples to unders…

This study examines whether women with primary Sjögren's syndrome, an autoimmune disease that causes dry eyes and mouth, also experience muscle loss, a condition called sarcopenia. Researchers will measure muscle strength, muscle mass, and physical performance in 120 participants…

This study will use a special blood test called mass spectrometry to look at immune cells in 500 people with various autoimmune diseases and healthy volunteers. The goal is to find patterns that could help doctors diagnose these conditions sooner. No treatments are being tested; …

This study aims to better understand fatigue by comparing people who have felt tired for more than a month with those who are not fatigued. Researchers will use questionnaires, physical tests, and optional brain scans to identify different types of fatigue. The goal is to gather …

This study looks at immune system markers in the saliva and blood of 80 people with primary Sjögren's syndrome, a chronic disease causing dry eyes and mouth. Researchers will check for antibodies that may block a key enzyme and see how gum disease affects symptoms. The goal is to…

This study was designed to track pregnancies in women with rare autoimmune and systemic diseases to understand complications and improve care. It planned to enroll women with conditions like lupus, rheumatoid arthritis, and scleroderma. However, the study was withdrawn before any…

This study looks at how common nerve problems are in people who feel eye discomfort. Researchers will test 1,000 participants to see if their pain is linked to nerve damage rather than just dry eye. The goal is to better understand these conditions and improve diagnosis.

This study looks at how well a new test called quantitative sensory testing (QST) can measure nerve function in the eye. Researchers will use heat, cold, and vibration to see how people with dry eye disease or corneal nerve damage respond. The goal is to better understand eye pai…

This study is testing whether a special microscope (in vivo confocal microscopy) can reliably detect tiny nerve growths called microneuromas in the cornea, which may be a sign of neuropathic corneal pain. Researchers will scan the eyes of 438 adults with dry eye or ocular pain to…

This study looks at whether changes in gut bacteria can affect Sjögren's syndrome, an autoimmune disease causing dry eyes, dry mouth, and fatigue. Researchers will measure blood markers of gut leakage in 50 adults with Sjögren's to see if these markers change when disease activit…

This study looks at whether helping people with inflammatory arthritis address social needs—like food, housing, or transportation—can reduce missed doctor visits. About 100 adults with conditions like rheumatoid arthritis or lupus who have missed appointments in the past year wil…

This study looks at immune cells from people with autoimmune diseases (like lupus), people with infections, and healthy volunteers. Researchers want to understand how these cells differ and what makes them attack the body in autoimmune conditions. The study involves blood and bon…