Intracranial arteriosclerosis

This study tests whether pemafibrate, a drug that lowers triglycerides, can prevent the worsening of narrowed brain arteries in people who have already had a stroke or mini-stroke. About 270 participants will be randomly assigned to receive either pemafibrate plus standard care o…

This trial tests whether low-dose colchicine, an anti-inflammatory drug typically used for gout, can reduce stroke risk and artery plaque in people with intracranial atherosclerotic disease (ICAD). ICAD is a leading cause of stroke in Asia, and even with standard treatment, the r…

This trial compares two strategies to prevent another stroke in people with severe narrowing of a major brain artery. One group receives a drug-eluting stent (a mesh tube that releases medication to keep the artery open) along with aggressive blood-thinning medication. The other …

This Phase 3 trial tests whether the drug tirofiban can help people who have had a stroke but missed the usual treatment window (more than 24 hours after symptoms start). The study uses a special MRI scan to select patients whose stroke is caused by a specific type of artery bloc…

This study tests whether adding a PCSK9 inhibitor (Recaticimab) to standard statin therapy can reverse plaque buildup in brain arteries of people with asymptomatic intracranial atherosclerosis. About 300 participants will receive either the drug combo or statins alone for 24 week…

This study tests whether a balloon angioplasty procedure can prevent early neurological decline in people who have had a minor stroke due to a narrowed brain artery. The trial will enroll 100 adults who have already received standard medication but still show fluctuating or worse…

This study looks at whether high-dose statins can reduce or stabilize fatty plaques in the brain's arteries that cause strokes. About 100 recent stroke patients will get intensive statin therapy and have their arteries scanned with a special MRI. The goal is to see if the plaques…

This study tests a new stent (a small mesh tube) placed in brain arteries to prevent strokes in people whose arteries are narrowed by plaque. It includes 200 adults aged 18-75 who have had a stroke or mini-stroke despite medication. The main goal is to see if the stent is safe an…

This study tests whether dulaglutide, a once-weekly diabetes injection, can improve blood flow in the brains of people with severely narrowed arteries. About 130 participants who recently had a mini-stroke or mild stroke will receive either standard care or dulaglutide plus stand…

This study compares two treatments for stroke patients whose brain arteries remain blocked after initial clot removal, due to underlying hardening of the arteries (atherosclerosis). About 498 participants will be randomly assigned to receive either urgent stenting or continued st…

This study looks at whether a genetic test can help doctors pick the right blood thinner for people who have had a stroke due to narrowed arteries in the brain. Some people's genes make the common drug clopidogrel less effective, so another drug, ticagrelor, may work better. The …

This study investigates whether high-resolution MRI can identify dangerous plaque features in the middle cerebral artery that might predict a second stroke. Researchers will follow 75 patients who had a first stroke due to significant narrowing of this artery, tracking which plaq…

This study looks at whether special MRI scans can help predict which people with severe narrowing of brain arteries (70-99% stenosis) are most likely to have another stroke. Participants have already had a minor stroke and are enrolled in a larger treatment trial. They will get a…

This study uses advanced 3D-rotational angiography to track how fatty plaques in brain arteries change over one year in 140 people who have had a stroke or mini-stroke. Participants will have two scans 12 months apart while managing heart risk factors. The goal is to understand p…

This study looks at fatty buildup in brain arteries that can break off and cause strokes. Researchers want to see if high-risk plaques look different from harmless ones. They will use special imaging to compare plaques in 140 people who have had a stroke with those who have not.

This study is building a biobank of blood, spinal fluid, and tissue samples from 500 Chinese adults, including stroke patients, their families, and healthy volunteers. Researchers will analyze the samples to find genetic markers linked to stroke and its complications. The goal is…

This study is testing a new, noninvasive MRI technique to see if it can better predict stroke risk in people with narrowed arteries in the brain (ICAS). Researchers will measure blood flow pressure using a special MRI scan and follow 400 participants for one year to see who has a…

This study follows 100 people with severe narrowing of brain arteries to understand why some develop memory and thinking problems. Participants receive either standard medications or a procedure to open the artery. Researchers will track changes in memory and stroke risk over tim…