Intracranial arteriosclerosis
MONDO:0001632Vascular diseases characterized by thickening and hardening of the walls of arteries inside the skull. There are three subtypes: (1) atherosclerosis with fatty deposits in the arterial intima; (2) Monckeberg's sclerosis with calcium deposits in the media and (3) arteriolosclerosis involving the small caliber arteries. Clinical signs include headache; confusion; transient blindness (amaurosis fugax); speech impairment; and hemiparesis.
35 clinical trials for this condition and its sub-types.
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New stent shows promise for blocked brain arteries
Disease control CompletedThis study tested a special stent designed to open severely narrowed brain arteries in 194 people with symptomatic intracranial atherosclerosis. The goal was to see if the stent is safe and effective at keeping arteries open for at least 12 months. Researchers measured how often …
Phase: NA • Sponsor: Medos International SARL • Aim: Disease control
Last updated Aug 09, 2026 00:00 UTC
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Zapping the brain to restore blood flow: a new hope for moyamoya patients?
Knowledge-focused CompletedThis study tests whether a mild electrical current applied to the scalp (tDCS) can increase blood flow to the brain in people with Moyamoya disease or hardened brain arteries. Researchers will measure changes in blood flow using MRI and check if thinking skills improve. The study…
Phase: NA • Sponsor: Mayo Clinic • Aim: Knowledge-focused
Last updated Aug 07, 2026 00:00 UTC
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Gut bacteria may hold clues to stroke recovery
Knowledge-focused CompletedThis study looked at 120 people who had an acute ischemic stroke to see if the types of bacteria in their gut were linked to how well they recovered. Researchers analyzed stool samples and brain scans, and tracked disability over 6 months. The goal was to understand the role of g…
Sponsor: Chinese University of Hong Kong • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:07 UTC
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New MRI dye could reveal hidden brain artery inflammation
Knowledge-focused CompletedThis study tested whether a special MRI contrast agent called ferumoxytol can detect inflammation in brain arteries of people who recently had a stroke. Researchers compared it to standard gadolinium contrast in 30 participants with narrowed brain arteries. The goal was to see if…
Phase: PHASE1 • Sponsor: Yale University • Aim: Knowledge-focused
Last updated Jun 26, 2026 16:41 UTC
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Large study aims to predict stroke in silent artery disease
Knowledge-focused CompletedThis completed observational study followed 3,849 people with asymptomatic intracranial atherosclerosis (narrowing of brain arteries) to better understand how the disease progresses and to improve stroke prediction. Participants underwent routine imaging and cognitive tests over …
Sponsor: Xuanwu Hospital, Beijing • Aim: Knowledge-focused
Last updated Jun 26, 2026 14:06 UTC