Intracranial arteriosclerosis
MONDO:0001632Vascular diseases characterized by thickening and hardening of the walls of arteries inside the skull. There are three subtypes: (1) atherosclerosis with fatty deposits in the arterial intima; (2) Monckeberg's sclerosis with calcium deposits in the media and (3) arteriolosclerosis involving the small caliber arteries. Clinical signs include headache; confusion; transient blindness (amaurosis fugax); speech impairment; and hemiparesis.
35 clinical trials for this condition and its sub-types.
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New blood thinner cocktails aim to outsmart stroke in High-Risk patients
Disease control OngoingThis large phase 3 trial tests whether newer blood thinner combinations (ticagrelor plus aspirin or rivaroxaban plus aspirin) are better than the standard clopidogrel plus aspirin at preventing stroke, brain bleeding, or death from blood vessel disease. Over 1,600 participants wi…
Phase: PHASE3 • Sponsor: University of Florida • Aim: Disease control
Last updated Aug 12, 2026 00:00 UTC
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New balloon coated with paclitaxel aims to keep brain arteries open
Disease control OngoingThis study tests a special balloon catheter coated with the drug paclitaxel to treat narrowed or re-narrowed brain arteries. The balloon is inflated inside the artery to open it and release the drug, which may help prevent the artery from closing again. The trial includes 281 adu…
Phase: NA • Sponsor: B. Braun Medical International Trading Company Ltd. • Aim: Disease control
Last updated Jun 27, 2026 13:07 UTC
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Brain stent blood thinner study pulled before it began
Disease control TerminatedThis study planned to compare taking blood thinners for 3 months versus 6 months after placing a special drug-coated stent in a narrowed brain artery. The goal was to see if the shorter treatment was just as good at preventing strokes and bleeding. However, the trial was withdraw…
Phase: NA • Sponsor: Sino Medical Sciences Technology Inc. • Aim: Disease control
Last updated Jun 27, 2026 07:59 UTC
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New MRI technique could help predict strokes in High-Risk patients
Knowledge-focused TerminatedThis study tested a new MRI method to better predict stroke risk in people with intracranial atherosclerosis, a condition where arteries in the brain become narrowed. Researchers measured how well different parts of the brain responded to changes in blood flow. The goal was to fi…
Phase: PHASE4 • Sponsor: Northwestern University • Aim: Knowledge-focused
Last updated Aug 08, 2026 00:03 UTC
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Brain artery test may spot hidden stroke risk
Knowledge-focused OngoingThis observational study is testing whether a new digital imaging analysis can more accurately predict stroke risk in 400 adults with narrowed brain arteries (50-99% blockage). Participants undergo standard angiography, and researchers use a computer method to measure blood flow …
Sponsor: Xuanwu Hospital, Beijing • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:07 UTC