Intracranial arteriosclerosis
MONDO:0001632Vascular diseases characterized by thickening and hardening of the walls of arteries inside the skull. There are three subtypes: (1) atherosclerosis with fatty deposits in the arterial intima; (2) Monckeberg's sclerosis with calcium deposits in the media and (3) arteriolosclerosis involving the small caliber arteries. Clinical signs include headache; confusion; transient blindness (amaurosis fugax); speech impairment; and hemiparesis.
35 clinical trials for this condition and its sub-types.
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Could a single shot boost stroke recovery? new trial aims to find out
Disease control Not yet recruitingThis study tests whether a single injection of Recaticimab, a cholesterol-lowering drug, can help people recover better after a stroke caused by narrowed brain arteries. About 1,200 participants will receive either the drug or a placebo, plus standard care. The main goal is to se…
Phase: PHASE4 • Sponsor: Peking Union Medical College Hospital • Aim: Disease control
Last updated Jul 17, 2026 00:00 UTC
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Brain training and new drug combo tested to fight memory loss in stroke risk patients
Disease control Not yet recruitingThis study tests whether a tablet-based brain training program and/or a powerful cholesterol-lowering drug (PCSK9 inhibitor) can improve thinking and memory in 420 adults aged 55-80 with narrowed brain arteries. Participants will be split into four groups, combining or not combin…
Phase: PHASE4 • Sponsor: Peking Union Medical College Hospital • Aim: Disease control
Last updated Jun 27, 2026 12:36 UTC
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New shot aims to slash stroke risk by crushing cholesterol
Disease control Not yet recruitingThis Phase 3 trial tests a new injectable drug, ongericimab, in about 4,800 people who recently had a stroke due to narrowed arteries. The goal is to see if lowering LDL cholesterol more than current standard care can prevent future strokes, heart attacks, or death from heart dis…
Phase: PHASE3 • Sponsor: Beijing Tiantan Hospital • Aim: Disease control
Last updated Jun 27, 2026 12:08 UTC
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Ancient herb may tame inflammation after heart attack
Disease control Not yet recruitingThis study tests whether Tanhuo decoction, a traditional herbal mixture, can reduce inflammation and prevent future heart or brain events in elderly patients who have had both a heart attack and hardened brain arteries. About 480 participants will take either the herbal drink or …
Phase: NA • Sponsor: Jinggang Xia, MD • Aim: Disease control
Last updated Jun 27, 2026 09:09 UTC
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New balloon procedure could prevent stroke in High-Risk patients
Disease control Not yet recruitingThis study tests a procedure called submaximal balloon angioplasty to improve blood flow in narrowed brain arteries and prevent stroke. It involves 159 people who recently had a mild stroke due to severe artery narrowing (70-99%). The procedure uses a small balloon inflated to a …
Phase: NA • Sponsor: Case Western Reserve University • Aim: Disease control
Last updated Jun 27, 2026 07:56 UTC
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New drug combo aims to stop repeat strokes in High-Risk patients
Prevention Not yet recruitingThis phase 3 trial will test whether a low dose of the blood thinner rivaroxaban plus aspirin can prevent recurrent strokes better than the standard clopidogrel plus aspirin in people with narrowed brain arteries. About 1,172 participants who recently had a stroke or high-risk TI…
Phase: PHASE3 • Sponsor: Population Health Research Institute • Aim: Prevention
Last updated Jun 27, 2026 11:01 UTC
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Could two blood thinners be better than one for stroke prevention?
Prevention Not yet recruitingThis study compares apixaban alone versus apixaban plus clopidogrel for 30 days in people who have had a stroke and have both atrial fibrillation and atherosclerosis. About 586 participants will be randomly assigned to one of the two treatments. The goal is to see if the combinat…
Phase: PHASE4 • Sponsor: Yonsei University • Aim: Prevention
Last updated Jun 27, 2026 07:57 UTC