Helminthiasis

This study tested the safety and effectiveness of the drug EGATEN (triclabendazole) in 301 people aged 6 and older with fascioliasis, a parasitic liver infection. Participants received two doses of EGATEN 12 hours apart and were followed for 90 days. The goal was to see if the dr…

This study tested a new vaccine called SchistoShield® in 120 healthy adults in Burkina Faso and Madagascar. The goal was to see if it is safe and triggers an immune response against schistosomiasis, a parasitic disease spread by snails. Participants received three doses of the va…

This study tested a new vaccine (Sm-TSP-2) to protect against intestinal schistosomiasis, a parasitic worm infection common in parts of Africa. Healthy adults in Uganda received different doses of the vaccine, with or without an immune booster, to check safety and how well it tri…

This study tested two doses (40 vs 80 mg/kg) of praziquantel in 354 children aged 1-4 with schistosomiasis in Uganda. The goal was to find the best dose to cure the infection and improve growth and anemia. Currently, praziquantel is not approved for children under 4, and this tri…

This large Phase 3 trial compared the safety of a single dose of moxidectin versus ivermectin in nearly 13,000 people living in areas where river blindness is common. Some participants also received albendazole for lymphatic filariasis. The goal was to see if moxidectin causes fe…

This study tested whether a drug called moxidectin, combined with other medicines, works better than the standard treatment (ivermectin combinations) for lymphatic filariasis, a parasitic disease that can cause severe swelling. 164 adults with the infection received a single dose…

This massive study tested whether giving deworming medicine (albendazole) to everyone in a community, not just children, can break the cycle of soil-transmitted worm infections. Over 350,000 people in India, Malawi, and Benin took part. The goal was to see if treating entire vill…

This study tested a vaccine called Bilhvax, given alongside a standard treatment (praziquantel), to see if it could delay the return of schistosomiasis (a parasitic infection) in children aged 6 to 9 in Senegal. The vaccine was given as three shots plus a booster one year later. …

This study looked at whether giving hospital-level care to acutely ill adults in their own homes in rural areas works well. 160 people with various conditions like infections, heart failure, or COPD took part. The goal was to see if this approach could lower costs and help patien…

This study tested whether higher doses of ivermectin, combined with albendazole, are safe and effective for treating whipworm infections in children aged 2 to 5 years. The trial involved 260 children in Tanzania and compared different doses of ivermectin, including a new dissolva…

This Phase 2 trial tested the drug albendazole in 194 people with early-stage alveolar echinococcosis, a parasitic liver disease that is nearly always fatal within 10-15 years if untreated. Participants took albendazole twice daily and were monitored with ultrasound to see if the…

This study tested whether combining two drugs—moxidectin and albendazole—works better than albendazole alone for treating whipworm infections in children aged 6 to 12. The trial took place in Tanzania and involved 224 children. Researchers measured how many children were cured an…

This study tested a single dose of moxidectin in 36 children aged 4 to 17 who have or are at risk of onchocerciasis (river blindness). The goal was to find a dose for children 4-11 years that works like the standard 8 mg dose used in older kids and adults. Researchers measured dr…

This study looked at how well a new, quick finger-prick test (LumiraDx CRP) measures CRP levels compared to a standard lab test. CRP is a marker of infection, inflammation, or tissue injury. 79 adults with symptoms of these conditions took part. The goal was to see if the new tes…

This study looked at three different blood tests (ELISA) for diagnosing strongyloidiasis, an infection caused by a parasite that can stay hidden in the body. Researchers tested 80 adult patients who had previously had a positive or borderline result. The goal was to see which tes…

This early study tested whether a special PET scan using a radioactive form of vitamin B9 (11C-PABA) can help doctors see infections deep inside the body. Researchers scanned 13 healthy people and patients with known or suspected infections. The goal was to see if this method can…

This completed study in Pemba, Tanzania, compared several diagnostic tests for Schistosoma haematobium, a parasitic worm that causes a debilitating disease. Researchers tested 801 schoolchildren using methods like urine filtration, AI microscopy, and molecular tests. The goal was…

This completed study looked at how common fish allergy is among people who work with fish, like fishermen and fish-processing factory workers, compared to other workers. Researchers surveyed 486 people in Boulogne-sur-Mer, France, asking about allergic symptoms and exposure to fi…

This study tested whether adding calisthenics (bodyweight exercises like push-ups and squats) to gym class helps teens get stronger and feel better about themselves. 100 students aged 13-16 were split into two groups: one did calisthenics for 12 weeks, the other followed standard…

This study tested whether giving deworming drugs during regular healthcare visits works better than the usual special campaigns. Over 1,200 people in Western Kenya took part, including community members, health workers, and officials. Researchers measured how practical, affordabl…

This study explored why some people with latent (inactive) tuberculosis (TB) are more likely to develop active TB. Researchers looked at 626 people in South India to see how malnutrition, diabetes, and worm infections might change the body's response to TB. Participants gave bloo…

This study looked at the medical records of 350 people in Najaf, Iraq, who had liver hydatid cysts—a parasitic infection common in the region. Researchers wanted to learn more about who gets the disease and how it shows up, so doctors can better treat and prevent it. The study di…

This study looked at why some people infected with TB bacteria get sick while others don't. Researchers in India studied 120 household contacts of TB patients, comparing those who were malnourished or had parasitic worms. They provided food and deworming medication to see how the…

This study looked at 156 critically ill patients to find out what factors help achieve the right levels of beta-lactam antibiotics in the blood. Researchers collected clinical data and used therapeutic drug monitoring to see which patients reached target concentrations. The goal …

This completed study looked at 141 people being treated for tuberculosis (TB) to see if intestinal parasites or poor nutrition made their recovery harder. Researchers checked stool samples for parasites and measured weight gain and treatment success. Some participants received nu…

This study surveyed nearly 1,000 students in Pemba, Zanzibar, to see how much they know about schistosomiasis (a parasitic disease) and how they feel about it. Researchers tested a health education program led by community volunteers to see if it improves students' knowledge, att…

This case report describes a 29-year-old man with a rare parasitic cyst in his shoulder muscle that was initially mistaken for a common synovial cyst. After incorrect treatment with steroids caused inflammation, doctors correctly diagnosed it through imaging and surgery. The pati…