New drug moxidectin put to the test against river blindness in massive safety trial
NCT ID NCT04311671
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This large Phase 3 trial compared the safety of a single dose of moxidectin versus ivermectin in nearly 13,000 people living in areas where river blindness is common. Some participants also received albendazole for lymphatic filariasis. The goal was to see if moxidectin causes fewer or less severe side effects. Results will help determine if moxidectin can be a safer alternative for controlling this parasitic disease.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- moxidectin (compared to ivermectin, with or without albendazole)
- What this could lead to
- If moxidectin proves safer, it could become a new treatment option for river blindness, potentially reducing side effects in affected communities.
- What could go wrong
- This trial only measures safety, not effectiveness. Even if safe, moxidectin may not work better than existing treatments. Results may not apply to all populations.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
-
Centre Suisse de Recherches Scientifiques en Coˆte d'Ivoire
Abidjan, Côte d’Ivoire
-
Centre de Recherche pour les Maladies Tropicales Negligees
Rethy, Ituri, Democratic Republic of the Congo
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