Helminthiasis

This study tests whether a single dose of a new drug, emodepside, can cure infections from soil-transmitted worms (like whipworm, hookworm, and roundworm) better than the current standard treatment, mebendazole, which requires multiple doses. About 315 adolescents and adults with…

This phase 3 trial tests whether combining two drugs—albendazole and ivermectin—works better than the standard single drug for treating whipworm infection in schoolchildren aged 6 to 15 in Honduras. Participants receive a single dose of either placebo, albendazole alone, albendaz…

This study tests whether one or two doses of the drug oxfendazole can cure chronic fascioliasis (a liver infection caused by a parasite) as well as the standard two-dose treatment with triclabendazole. About 336 adults in Peru will be randomly assigned to one of three groups. Res…

This study compares a single dose of emodepside to a single dose of albendazole (the usual treatment) in 100 adolescents and adults infected with a type of whipworm. The goal is to see which drug cures more infections and reduces egg counts. Participants provide stool samples bef…

This study tests a drug called oxfendazole for people with mild brain cysticercosis, a parasitic infection that can cause seizures. Researchers will compare a single dose and three doses of oxfendazole against the standard combination therapy. The goal is to see if oxfendazole cl…

This study compares two common antibiotic combinations—vancomycin with piperacillin/tazobactam versus vancomycin with meropenem—to see which is less harmful to the kidneys. About 852 hospitalized adults with serious infections will be randomly assigned to one of the two combos. T…

This early-stage trial will test whether surgeons in Chengdu can safely remove liver parasites from 10 patients in Lhasa (3,650m altitude) using a 5G-connected robot. The goal is to see if the remote surgery can be completed without major issues. If it works, it could bring exper…

This study tests different doses of a drug called arpraziquantel in children aged 6-7 who are infected with a liver fluke parasite (Opisthorchis viverrini). The goal is to find the safest and most effective dose to cure the infection. 125 children will receive one of several dose…

This study looks at how well the oral medication selexipag works over the long term for people with a specific type of lung hypertension caused by schistosomiasis (a parasitic infection). Researchers will compare patients who received selexipag as part of routine care to similar …

This large study in Fiji tests whether a new combination of drugs (moxidectin plus two others) can safely treat three common parasitic infections: lymphatic filariasis, scabies, and strongyloidiasis. About 5,100 people will receive either the new combo or the standard treatment o…

This study tests whether a mobile app using artificial intelligence can help frontline health workers in sub-Saharan Africa better diagnose skin-related neglected tropical diseases, like leprosy and scabies. Researchers will collect images from dermatologists to train the AI, the…

This study aims to develop a new urine test for schistosomiasis, a parasitic infection. Researchers will test a nanobody-based strip on 2500 participants, comparing it to the standard microscope method. If accurate, it could offer a quick, non-invasive diagnostic tool.

This observational study will look at 10,000 adults in intensive care units (ICUs) around the world during a single 24-hour period. Researchers want to find out how common infections and antibiotic-resistant bacteria are, how they are treated, and how patients recover. No new tre…

This research project aims to understand why older adults get more infections and why those infections can be more serious. By following 23,000 people aged 60 and older, scientists will collect health data and samples like blood and stool to study how the immune system changes wi…

This study will measure how many people in Assiut Governorate, Egypt, have schistosomiasis, a parasitic disease. Researchers will test urine and stool samples from 359 participants and ask about risk factors. The goal is to better understand the current burden of the disease in t…

This study will collect blood samples from 30,000 adults in the UK with various health conditions, including blood clots, infections, heart disease, diabetes, and more. The samples will be used to develop and fine-tune new diagnostic tests for the cobas® lumira device, which allo…

This study will follow 300 adults with severe infections in the ICU to see how levels of specialized pro-resolving mediators (SPMs)—natural molecules that help stop inflammation—change over time. Researchers will use blood samples already collected during routine care, so no extr…

This study tests whether watching a single episode of the medical drama House M.D. can boost knowledge about neurocysticercosis, a parasitic brain infection that can cause epilepsy. Sixty young adults aged 18-35 will be randomly assigned to either watch the episode or not, and th…

This study will test a new way to care for people in Ghana who have both a neglected tropical skin disease (like leprosy or Buruli ulcer) and mental health challenges like depression or anxiety. Researchers will work with 200 affected adults and local health workers to create a G…