Helminthiasis

This phase 2 trial tests whether a single dose of the experimental drug oxfendazole can cure whipworm (Trichuris trichiura) infection better than the standard treatment albendazole. About 249 adults in Peru, where whipworm is common, will receive either 400 mg or 800 mg of oxfend…

This study tests different doses of a drug called arpraziquantel in children aged 6-7 who are infected with a liver fluke parasite (Opisthorchis viverrini). The goal is to find the safest and most effective dose to cure the infection. 125 children will receive one of several dose…

This study at the National Institutes of Health evaluates and treats people aged 3 and older with known or suspected parasitic infections, such as malaria, intestinal worms, and others. Participants receive standard medical care, not experimental treatments. The goal is to monito…

This study tests a community-designed strategy to deliver preventive chemotherapy to mobile and migrant populations in Nigeria, who often miss treatment for neglected tropical diseases like river blindness and schistosomiasis. Researchers will work with communities to map migrati…

This study tests a new surgical technique for people with liver echinococcosis (a parasitic infection) who develop bile leaks after surgery. The method uses a special medical glue to seal the leak, aiming to reduce complications and speed up recovery. Researchers will track how o…

This study compares two drugs, ivermectin and moxidectin, to see which works better at controlling river blindness and other common infections like intestinal worms and scabies in Angola. Over 52,000 people in 20 village groups will receive one of the drugs once a year for four y…

This study aims to see how well a new, child-friendly version of the drug praziquantel works to control schistosomiasis in preschool-aged children (2 to 5 years old) in parts of Kenya, Côte d'Ivoire, and Uganda. About 18,500 children will receive the medicine through existing pub…

This phase 3 trial tests a chewable tablet called ZP5-9676 (flubendazole) against common intestinal worms like hookworm, roundworm, and whipworm. About 300 people aged 6 months to 59 years from high-risk areas will receive either the drug or a placebo. The goal is to see if the d…

This study aims to create a homemade PCR test to detect echinococcosis, a parasitic disease, more quickly and accurately than current methods. Researchers will collect biological samples from patients suspected of having the infection, especially those undergoing surgery to remov…

This large Phase 3 trial in Ghana and Kenya will test whether a single dose of a new albendazole-ivermectin combination pill works better than the standard albendazole alone to prevent soil-transmitted worm infections in 20,000 school-aged children. The study focuses on safety an…

This study follows 500 people with neurocysticercosis, a brain infection caused by the pork tapeworm. Participants receive standard antiparasitic drugs and anti-inflammatories. Researchers will track their health over many years to understand what factors lead to better or worse …

This study aims to understand how and why eosinophils (a type of white blood cell) become active in conditions like allergies, asthma, and parasitic infections. Researchers will observe up to 800 people aged 1 to 100 with high eosinophil levels. No experimental treatments are giv…

This study looks at how people's immune systems react to infections from parasitic worms, which can cause serious health problems like swelling, blindness, or heart disease. Researchers will evaluate and treat up to 500 participants aged 3 to 100 using standard medical tests and …

This study is testing whether giving healthy adults a controlled dose of whipworm eggs is safe and can cause a mild infection. Researchers will try different egg doses in 18 volunteers to find the best balance of safety and infection. The goal is to create a reliable human infect…

This study aims to find the safest and most consistent dose of hookworm larvae to use in future vaccine trials. Healthy adults aged 18 to 45 will receive different numbers of hookworm larvae through the skin. Researchers will monitor side effects and measure hookworm eggs in stoo…

This study looks at how common certain infections are among 250 asylum seekers living in reception centers in Italy. Participants must be adults who arrived in Italy between 2 and 36 months ago. The goal is to better understand infection rates to improve health screening and care…

This study aims to find out how common female genital schistosomiasis (FGS) is among migrant women aged 15-49 who have gynecological symptoms and come from countries where the parasite is found. Researchers will use vaginal swabs and PCR tests to detect the infection, which is no…

This study will test 10,000 people in Cambodia for 57 different infectious diseases, including dengue, flu, and malaria. Researchers want to understand how these diseases spread and who is at risk. The goal is to give local health authorities the information they need to create b…

This study looks at 100 adults with inactive liver cysts caused by a parasite. Researchers compare immune system markers between people who received treatment and those who did not. The goal is to learn how the body responds over time, not to test a new treatment.

This study looks at whether tiny parasite cells (germinal elements) are present in the liver tissue right next to or inside the fibrous wall of hydatid cysts in people with liver echinococcosis. Researchers will collect tissue samples from 100 patients during surgery to check for…