Congestive heart failure

This trial tests whether a dietary supplement called Endocalyx Pro can reduce excess sodium and water in people with chronic heart failure. Participants will take either the supplement or a placebo daily for 8 weeks, with follow-up for 12 weeks. The study measures changes in a bl…

This study tests a device that electrically stimulates the vagus nerve to help manage heart failure. About 118 patients with moderate-to-severe heart failure received the implant. The goal is to see if this stimulation can improve heart function and exercise capacity over six mon…

This study investigates whether diagnosing and treating obstructive sleep apnea with CPAP therapy early, while patients are still in the hospital for heart problems, can reduce the chance of being readmitted within 30 days. The trial enrolls adults with heart failure, heart attac…

This study tests whether giving oral salt tablets alongside standard IV diuretics helps hospitalized heart failure patients lose more fluid and maintain better kidney function. About 67 adults with acute decompensated heart failure will receive either salt or placebo three times …

This study tests a transitional care model for older adults (65+) hospitalized with heart failure, COPD, or pneumonia. The model provides extra education, social services, and coordination among doctors after discharge. Researchers compare this to usual care to see if it reduces …

This study tests a nurse-led program that uses home monitoring devices to help older adults with conditions like heart failure, diabetes, and depression manage their health after leaving the hospital. The goal is to improve care coordination and reduce hospital readmissions. Abou…

This study looks at whether doing a preventive heart ablation (a procedure to destroy small areas of heart tissue causing irregular rhythms) before LVAD surgery can reduce serious problems like dangerous heart rhythms, death, blood clots, or heart failure in the first 30 days aft…

This trial aimed to test whether infusions of stem cells from donated fat tissue could improve heart function in people recently diagnosed with non-ischemic heart failure. Participants would have received two infusions a month apart. However, the study was withdrawn before enroll…

This study tests whether a nurse practitioner-led team can improve care for adults with two or more chronic conditions like heart failure, diabetes, or kidney disease. Participants are randomly assigned to either the nurse-led team or usual care. The team reviews medications to e…

This study tests a digital platform that collects health data from heart failure patients, heart transplant recipients, and those with heart pumps. 390 participants will use sensors and a mobile app to track vital signs, activity, and more. Doctors in the intervention group can s…

This early study tests a temporary heart pump called Impella BTR in 10 adults with severe heart failure. The pump is placed inside the body to help the heart pump blood for up to 28 days. The goal is to see if the device is safe and can support patients until they recover or rece…

This trial studies whether a special pacing feature called SyncAV, used in heart devices, can improve heart function in people with congestive heart failure. About 1,686 participants will get a new or upgraded heart device and be randomly assigned to have SyncAV on or a standard …

This study tests whether giving people free fruits and vegetables (a produce prescription) along with culturally tailored cooking classes can improve their nutrition and help manage chronic conditions like diabetes and high blood pressure. Thirty adults who already take medicatio…

This study tests a one-time gene therapy called AB-1002, given directly into the heart arteries, for people with advanced heart failure (NYHA Class III). The goal is to see if it can improve heart function, reduce symptoms, and lower the risk of death or hospitalization. About 15…

This study tests a new, non-invasive method called ezCVP to measure central venous pressure (a key heart health indicator) in 30 adults with heart failure in the ICU. It compares ezCVP to the standard invasive method that uses a catheter. The goal is to see if ezCVP can accuratel…

This study explores whether fluid from the skin can be used to detect signs of heart disease. Researchers will collect skin fluid and blood samples from 30 volunteers, including older adults with heart failure and younger healthy adults. The goal is to see if certain biomarkers i…

This early-stage study tests whether the drug atibuclimab (IC14) is safe and helpful for adults hospitalized with sudden worsening heart failure. Ten participants receive one IV dose of the drug and are monitored for side effects, drug levels, and heart failure markers. The goal …

This study aimed to see if a single dose of bumetanide given as a nasal spray could quickly lower blood pressure in the lungs and reduce blood volume in people with heart failure. Participants would have had a heart monitor implanted. However, the trial was withdrawn before enrol…

This study tests whether adding a traditional Japanese herbal medicine called Goreisan to standard heart failure treatment can help reduce fluid buildup (edema) in the body. About 1,179 adults with worsening heart failure and signs of fluid overload are being randomly assigned to…

This study looks at whether taking ketone or hawthorn supplements for 8 weeks can improve exercise ability and heart function in people with congestive heart failure. About 45 adults with mild to moderate heart failure will be randomly assigned to receive one of the supplements o…

This study compares two ways of delivering a health and wellness program to people with chronic conditions like diabetes and high blood pressure. One group gets a kit with a tablet and home monitors for blood pressure and blood sugar; the other gets standard phone calls. The goal…

This study looks at whether using a simple bedside ultrasound exam on all hospitalized patients can shorten their hospital stay. Researchers will check the heart, kidneys, liver, and lungs for common problems. The goal is to see if this routine check helps doctors make faster dec…

This study looks at tiny pieces of RNA in the blood of people with congestive heart failure. Researchers want to see if these RNA levels change with treatment and if they can predict heart health or future heart problems. About 400 adults with heart failure will be followed durin…

This study looks at medical records from over 600 Indian adults with chronic heart failure who were prescribed vericiguat between 2022 and 2023. Researchers want to see how the drug is used in routine care, how well it works, and what side effects occur. No new tests or visits ar…

This study analyzes data from over 4,200 heart failure patients to create a tool that uses biomarkers to guide diuretic dosing. Researchers aim to develop a machine-learning algorithm that could personalize treatment and improve outcomes. The study is observational and does not t…

This study looks at 50 adults hospitalized with acute decompensated heart failure who need intravenous diuretics (water pills). Researchers want to see if a non-invasive monitor called the Starling System can accurately measure changes in heart function as fluid is removed. The g…

This trial aimed to see if an AI program could help doctors choose better heart failure treatments for each patient. It planned to compare standard care with AI-generated treatment advice. However, the study was withdrawn before enrolling any participants, so no results are avail…

This study examines whether SGLT2 inhibitors, a type of diabetes drug, can improve red blood cell production and heart/kidney function in people with chronic heart failure. Researchers will compare blood tests, heart ultrasound measures, and clinical outcomes between 85 patients …

This study looks at whether a special PET scan can help doctors better predict sudden cardiac arrest in people with heart failure and blocked arteries. About 300 participants who already have a defibrillator will be followed to see if heart nerve damage, heart size, or blood mark…

This study tests a smartphone app that listens to your voice to catch early signs of heart failure getting worse. 123 people who were in the hospital for heart failure will record their voice daily for 6 months. The app looks for voice changes that might signal a problem, but doc…

This study followed nearly 6,000 adults aged 65 and older to learn what factors predict heart disease, stroke, and related health problems. Researchers aimed to identify risks and understand what leads to disability or death after a heart event. The study did not test a new treat…

This study creates a registry of 240 patients hospitalized with decompensated heart failure with preserved ejection fraction. Researchers will track medical history, body composition, imaging, and blood markers to see how these factors relate to short- and long-term outcomes. The…

This study looks at people with rare adrenal tumors (pheochromocytomas and paragangliomas) that do not produce excess hormones. Researchers want to see if these 'silent' tumors still cause heart problems, blood pressure changes, or metabolic issues like diabetes and high choleste…

This study aimed to see if simple electronic reminders could help doctors reduce risky medication combinations in older patients. It planned to enroll primary care clinicians and use behavioral nudges in the electronic health record. However, the trial was withdrawn before any pa…

This study looks at tiny RNA molecules in the blood of 200 people hospitalized with acute congestive heart failure. Researchers want to see if these RNA levels change as patients receive decongestive therapy and if they can help predict who will respond well to treatment. The goa…

This study was designed to see if helping heart patients with social problems like food, housing, and mental health could keep them out of the hospital. The researchers planned to screen patients and connect them to community resources. However, the study was withdrawn before enr…