Clostridium difficile colitis

This early-stage trial tests an oral capsule containing a genetically modified probiotic yeast designed to neutralize toxins produced by C. diff bacteria. The study first evaluates safety in healthy adults, then in people at risk for recurrent C. diff infection. Participants take…

This study tests whether oral vancomycin, an antibiotic, can help children aged 6-15 with inflammatory bowel disease (IBD), especially types linked to liver problems. About 140 kids will either get vancomycin plus standard care or standard care alone for up to a year. Researchers…

This study will test hyperbaric oxygen therapy (HBOT) — breathing pure oxygen in a pressurized chamber — for over 30 conditions, including long COVID, Crohn's disease, frostbite, and multiple sclerosis. Researchers will track 100 patients to see if HBOT improves their quality of …

This study compares two common antibiotic combinations—vancomycin with piperacillin/tazobactam versus vancomycin with meropenem—to see which is less harmful to the kidneys. About 852 hospitalized adults with serious infections will be randomly assigned to one of the two combos. T…

This early-phase study tests a new treatment called ICG318 CAR-T for people with inflammatory bowel disease (IBD) that hasn't improved with standard therapies. The treatment uses a patient's own immune cells, modified in a lab to target and calm the overactive immune response cau…

This phase 2 trial tests an oral drug called ibezapolstat in 20 people who have had three or more C. diff infections in the past year. The goal is to see if the drug can cure the current infection and reduce the chance of it coming back. Participants will take the drug twice a da…

This study tests if xylitol, a common sweetener, can safely clear C. difficile bacteria from the gut in people with inflammatory bowel disease (IBD). About 99 adults with mild or inactive IBD will take either a low or high dose of xylitol or a placebo for four weeks. Researchers …

This pilot study tests whether xylitol, a common sugar alcohol, can safely clear C. difficile bacteria from the guts of people with inflammatory bowel disease (IBD). About 69 adults with mild or inactive IBD will take different doses of xylitol for up to 8 weeks. Researchers will…

This study compares two antibiotics, fidaxomicin and vancomycin, to see which one is better at clearing C. difficile bacteria from the gut in people with inflammatory bowel disease (IBD). About 60 adults with IBD will take one of the two antibiotics for 10 days and be followed fo…

This early-phase trial tests whether adding Ursodeoxycholic Acid (UDCA) to standard antibiotics can prevent Clostridioides difficile (C. diff) infection from returning. About 30 adults with C. diff and risk factors for recurrence will take UDCA three times daily for up to eight w…

This study tests whether taking oral vancomycin alongside other antibiotics can prevent Clostridioides difficile infection (C. diff) in people aged 65 and older. Participants are randomly assigned to receive either vancomycin or standard care. The goal is to see if the drug reduc…

This study tests whether a probiotic supplement in oral drops can prevent diarrhea in children aged 0-12 who are taking common antibiotics like amoxicillin. One thousand children will receive either the probiotic or a placebo during their antibiotic course, and researchers will t…

This study tests whether neurofeedback — a type of brain training using real-time brainwave feedback — can reduce musculoskeletal pain in people with chronic inflammatory bowel disease (IBD). Eighty adults with IBD and persistent pain will be randomly assigned to either 8 session…

This study will follow 100 adults with Crohn's disease, ulcerative colitis, or other IBD, plus their healthy relatives, for up to 3 years. Researchers will collect blood, stool, tissue samples, and imaging to track how immune cells and genetics change over time. The goal is to fi…

This observational study will look at 10,000 adults in intensive care units (ICUs) around the world during a single 24-hour period. Researchers want to find out how common infections and antibiotic-resistant bacteria are, how they are treated, and how patients recover. No new tre…

This research project aims to understand why older adults get more infections and why those infections can be more serious. By following 23,000 people aged 60 and older, scientists will collect health data and samples like blood and stool to study how the immune system changes wi…

This study looks at a new way to control inflammation during flare-ups of Crohn's disease and ulcerative colitis. Researchers will take blood samples from 30 adults with severe IBD and test whether oxygen microbubbles can reprogram immune cells (monocytes) to produce fewer inflam…

This study looks at adults who had a C. diff infection and were treated with either a fecal transplant (FMT) or antibiotics alone. Researchers want to see if FMT leads to healthier gut bacteria and fewer health problems years later. Participants will give blood, stool, and urine …

This study will give fecal transplants to 90 people with recurrent C. difficile infection, ulcerative colitis, or metabolic syndrome. Researchers will use advanced tests on stool and tissue samples to track how donor bacteria settle in the gut and interact with the host. The goal…

This early-stage study will give a single dose of the experimental antibiotic gepotidacin to 20 hospitalized children aged 2 to 12 who are already receiving standard antibiotics for a bacterial infection or as a preventive measure. Researchers will measure how the drug moves thro…

This study will examine 100 patients with lower gut symptoms like chronic diarrhea, blood in stool, or abdominal pain who are having a colonoscopy. Researchers want to see which types of colon inflammation (colitis) are most common and how they appear during the procedure. The go…

This study looks at how weight and body mass index (BMI) change in people with inflammatory bowel disease (IBD) who are treated with biologic drugs. Researchers will track weight monthly and see if higher BMI leads to higher drug doses and costs. The goal is to understand the fin…

This study will follow 83 adults with inflammatory bowel disease (IBD) at Assiut University Hospitals in Egypt to see if anemia can predict worse outcomes like hospitalizations. Anemia is common in IBD, but its role as a predictor is not well studied in this population. Researche…

This study will collect blood samples from 30,000 adults in the UK with various health conditions, including blood clots, infections, heart disease, diabetes, and more. The samples will be used to develop and fine-tune new diagnostic tests for the cobas® lumira device, which allo…

This study will follow 300 adults with severe infections in the ICU to see how levels of specialized pro-resolving mediators (SPMs)—natural molecules that help stop inflammation—change over time. Researchers will use blood samples already collected during routine care, so no extr…

This study looks at how obesity influences treatment response in 120 adults with inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis. Researchers will track whether obese patients respond differently to standard therapies, especially biologics. The …

This study will check if certain blood cell measurements (platelet count, size, and shape) are linked to how active inflammatory bowel disease (IBD) is. Researchers will compare these blood test results with standard disease activity scores in 84 adults with IBD. The goal is to s…

This study will check how common Helicobacter pylori infection is in 100 adults with inflammatory bowel disease (Crohn's or colitis) at the Guadeloupe hospital. Researchers will take extra stomach biopsies during routine endoscopy to study the stomach's bacteria. The goal is to s…

This study compares a newer imaging method called TXI with standard dye-based imaging during colonoscopies in people with inflammatory bowel disease (IBD). The goal is to see which method better detects precancerous changes that can lead to bowel cancer. About 242 adults with IBD…

This study will use a detailed heart ultrasound technique called speckle tracking to look for early signs of heart trouble in 100 adults with inflammatory bowel disease (IBD). Researchers want to see if this method can catch heart changes before they become serious and how those …

This study will look at 150 infants and children aged 1 month to 4 years who are admitted to a hospital gastroenterology unit with a gastrointestinal disease. The goal is to find out how common electrolyte disturbances (like low sodium or potassium) are in these children. By meas…