Clostridium difficile colitis
MONDO:0000705A bacterial infection of the colon secondary to infection with Clostridium difficile bacteria. This infection generally results from the loss of normal gut flora secondary to recent antibiotic use, and manifests as copious watery stools, with associated abdominal pain and myalgia. C. difficile is the most common cause of pseudomembranous colitis, and can progress to toxic megacolon if left untreated.
Also known as: C. diff colitis, C. diff infection, Clostridioides difficile caused colitis (disease), Clostridioides difficile colitis (disease), Clostridium difficile infection, pseudomembranous colitis
170 clinical trials for this condition and its sub-types.
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Promising c. diff drug fails to prove benefit in small, halted trial
Disease control TerminatedThis study tested whether an extra dose of bezlotoxumab, a drug that blocks the harmful toxin made by C. diff bacteria, could help very sick patients recover after emergency colon surgery. Only 5 people took part before the study was stopped early. The goal was to see if the drug…
Phase: PHASE4 • Sponsor: Ohio State University • Aim: Disease control
Last updated Jun 27, 2026 14:00 UTC
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New hope for recurring c. diff: which treatment works best?
Disease control TerminatedThis study tested three different antibiotic regimens for people with recurrent Clostridium difficile infection (C. diff), a serious gut infection that keeps coming back. The goal was to see if newer drugs like fidaxomicin or a tapered/pulsed course of vancomycin work better than…
Phase: PHASE4 • Sponsor: VA Office of Research and Development • Aim: Disease control
Last updated Jun 27, 2026 08:04 UTC
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Promising c. diff drug trial halted after just 3 patients
Disease control TerminatedThis study tested a new drug called REC-3964 to see if it could prevent repeat Clostridioides difficile (C. diff) infections in adults. Only 3 people were enrolled before the trial was stopped early. The goal was to check safety and whether the drug helped people stay infection-f…
Phase: PHASE2 • Sponsor: Recursion Pharmaceuticals Inc. • Aim: Disease control
Last updated Jun 27, 2026 07:57 UTC
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Antibiotic teicoplanin tested for stubborn gut infection
Disease control TerminatedThis study tested the antibiotic teicoplanin (taken by mouth twice daily for 7 to 14 days) in 50 adults hospitalized with C. difficile infection causing diarrhea and colitis. The goal was to see if it could stop diarrhea and prevent it from coming back. The trial was terminated e…
Phase: PHASE4 • Sponsor: Sanofi • Aim: Disease control
Last updated Jun 27, 2026 07:51 UTC
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Mesh may stop hernias after stoma closure, but study halted early
Prevention TerminatedThis pilot study tested whether placing a special mesh during ileostomy closure surgery could prevent hernias in people with inflammatory bowel disease. Only 8 patients were enrolled before the study was stopped. The main goal was to check safety, like infections or wound problem…
Phase: NA • Sponsor: Dartmouth-Hitchcock Medical Center • Aim: Prevention
Last updated Jun 27, 2026 09:09 UTC
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Sticker shock: simple reminder may cut unnecessary IV antibiotic use
Knowledge-focused TerminatedThis study tested whether placing a reminder sticker on the charts of adult hospital patients receiving IV fluoroquinolone antibiotics would encourage doctors to switch them to oral pills sooner. The trial involved 168 patients at a single hospital in Thailand. Unfortunately, the…
Phase: NA • Sponsor: Mahidol University • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:12 UTC