Clostridium difficile colitis

This trial tests whether ferric maltol, an oral iron supplement, can safely raise hemoglobin levels in adults with inflammatory bowel disease (IBD) who have iron deficiency anemia and have not responded to or cannot tolerate standard ferrous iron pills. Participants take either f…

This study tests whether a peer coaching program delivered by phone and text can help adolescents and young adults (ages 16–22) with chronic conditions like sickle cell disease, diabetes, or cystic fibrosis improve their self-management skills. Participants are paired with a trai…

This trial tests whether a nurse-led education program, based on the Health Belief Model, can improve treatment adherence in people with inflammatory bowel disease (Crohn's disease or ulcerative colitis) who are receiving anti-TNF therapy. The program aims to address patients' co…

This study tested whether cleaning therapy dogs with a special disinfectant (chlorhexidine) before hospital visits could reduce the spread of harmful germs to children. The trial involved 45 children aged 3 to 17 who interacted with therapy dogs. Researchers checked if the cleani…

This study tested a treatment called RBX2660 (REBYOTA) for people with recurrent Clostridioides difficile infection. The treatment is made from healthy human stool bacteria and was given during a colonoscopy. The goal was to see if this delivery method is safe and works well. For…

This study looked at whether giving the antibiotic vancomycin helps cancer patients who have diarrhea and a positive screening test for C. difficile but a negative toxin test. Only 9 patients were enrolled, far fewer than planned. Researchers measured changes in C. difficile leve…

This study tested whether eating less fat and more fiber can reduce the chance of a repeat Clostridioides difficile infection in cancer patients. Eight participants with leukemia, lymphoma, or other cancers followed a specific diet. Researchers tracked diarrhea and measured C. di…

This study tested whether taking capsules containing healthy gut bacteria could help clear drug-resistant germs (including C. difficile) from the intestines of 42 hospitalized adults who needed at least 7 days of antibiotics. Participants received either the bacteria capsules or …

This phase 2 study tested an experimental antibiotic called CRS3123 against the standard treatment vancomycin for Clostridioides difficile infection (C. diff). 43 adults with a first episode or first recurrence of C. diff took either CRS3123 or vancomycin for 10 days. The main go…

This study tested fecal microbiota transplant (FMT) in 24 adults with recurrent Clostridium difficile infection (C. diff) that didn't get better with standard antibiotics. FMT involves placing healthy donor stool into the patient's colon to restore good bacteria. The goal was to …

This study tested whether adding the drug bezlotoxumab to standard treatment could prevent serious outcomes in people with a severe C. diff infection. Researchers used a special score to identify 44 high-risk patients. The goal was to see if the drug reduced organ failure, infect…

This study followed 150 people with inflammatory bowel disease (ulcerative colitis or Crohn's disease) who were given VedAryo (vedolizumab) to see if it helps control their condition and is safe. Participants received the drug by IV at the start, after 2 weeks, after 6 weeks, and…

This study tests a new delayed-release metronidazole capsule designed to release the drug directly in the colon, where C. diff bacteria live. 18 healthy adults will receive a single dose of either the new capsule or the standard tablet to compare how much drug reaches the colon v…

This study looked at four substances in the blood (Osteoprotegerin, sRANKL, NFkB, and TFF3) to see if they could help diagnose inflammatory bowel disease (IBD), which includes Crohn's disease and ulcerative colitis. Researchers measured these markers in 70 newly diagnosed patient…

This study tests whether a probiotic supplement in oral drops can prevent diarrhea in children aged 0-12 who are taking common antibiotics like amoxicillin. One thousand children will receive either the probiotic or a placebo during their antibiotic course, and researchers will t…

This observational study followed 145 adults who received REBYOTA™ to prevent another Clostridioides difficile infection (CDI) after completing antibiotics. Researchers collected information from medical records over 6 months to see how many people stayed infection-free. The goal…

This study tested whether extending standard vancomycin treatment for C. diff infection with a 2-week taper (lowering the dose gradually) reduces the chance of the infection returning. 263 adults who had a first episode or first recurrence of C. diff were randomly assigned to rec…

This study tested whether combining a fecal microbiota transplant (FMT) with the drug bezlotoxumab could prevent repeat Clostridium difficile infections in people with inflammatory bowel disease (IBD). Sixty-one adults with at least two prior C. diff infections were randomly assi…

This study tested a 21-step enhanced recovery protocol for children aged 10-18 undergoing elective gastrointestinal surgery. The protocol included things like shorter fasting times, early eating and moving, and less use of opioids. The goal was to see if it could shorten hospital…

This study looked at whether placing a bridge device during loop ileostomy creation reduces complications like infections or stoma problems. 166 adults having elective colorectal surgery took part. The goal was to see if the device improves outcomes or just adds difficulty to car…

This study tested whether nurse coaching could help people with inflammatory bowel disease (IBD) better manage their symptoms, improve self-care, and enhance quality of life. Forty adults with IBD in remission participated. Researchers measured changes in symptom burden, self-car…

This small study tested whether an AI-powered virtual reality app could safely provide mental health support to 22 adults with inflammatory bowel disease (IBD) who also had mild anxiety or depression. The goal was to see if the digital session was practical and acceptable, not to…

This study compares two ways of doing colonoscopy in people with inflammatory bowel disease (IBD) who are at higher risk for colon cancer. One method takes biopsies only from visible abnormal areas, while the other also takes random biopsies from normal-looking tissue. The goal i…

This study measured how often adults with inflammatory bowel disease (Crohn's disease or ulcerative colitis) show signs of eating disorders, including avoidant/restrictive food intake disorder (ARFID). Researchers used questionnaires to assess eating habits and nutritional status…

This study looked at how much of the drug risankizumab (Skyrizi) passes into the breast milk of women with inflammatory bowel disease (IBD). Ten breastfeeding mothers who were already taking the drug provided milk samples over several weeks. The goal is to understand potential ex…

This study looked at 120 adults with inflammatory bowel disease (IBD) to see if simple stool tests can tell if the disease is active or in remission, just like a colonoscopy does. Colonoscopy is the current gold standard but is expensive, invasive, and not ideal for frequent chec…

This study looked at how a short course of antibiotics changes the nerve and glia cells in the lower gut of 10 healthy adults. Researchers took colon tissue samples before and after antibiotic treatment to count these cells and measure gene activity. The goal was to understand if…

This study looked at 139 children having a colonoscopy to see how often the CMV virus is found in their gut tissue and blood. Some children had inflammatory bowel disease (Crohn's or colitis) and some did not. The goal was to learn which tests best detect CMV in the gut, helping …

This early-stage study tested a single dose of AZD5148, a potential treatment for C. difficile infection, in 16 healthy Japanese adults. The main goal was to see if the drug is safe and how the body processes it. Participants received either the drug or a placebo by injection and…

This study looked at how the immune system responds to Clostridium difficile infection in hospitalized patients. Researchers took blood samples every two days to measure immune markers. The goal was to find out why some patients have repeat infections. The study involved 56 parti…

This study looked at how well stool and blood samples could be collected from 7 adults with an active C. diff infection. Researchers wanted to see if the collection, shipping, and testing methods worked smoothly. Participants also filled out questionnaires about their symptoms. T…

This completed study examined gut bacteria in 15 people with inflammatory bowel disease (IBD) or Parkinson's disease, comparing them to healthy individuals. Researchers analyzed stool and blood samples to see if bacteria from the gut move into the bloodstream. The goal was to und…