Cecal disorder

This phase 2 trial tested a combination of two drugs—paclitaxel (given intravenously and directly into the abdomen) and oral nilotinib—in 21 adults with cancers that had spread to the lining of the abdomen and could not be surgically removed. The goal was to see if the treatment …

This study tested an experimental drug called CBX-12 in 69 adults with advanced solid tumors (like ovarian, lung, breast, or colon cancer) that had stopped responding to standard therapies. The main goals were to check the drug's safety, find the best dose, and see if it could sh…

This study tested whether tranexamic acid, a drug that helps blood clot, can lower the chance of infection after gastrointestinal surgery. Over 3,300 adults at higher risk for complications took part. The goal was to see if the drug reduces surgical site infections compared to a …

This study tested a treatment for peritoneal carcinosis, a cancer that has spread to the lining of the abdomen from the stomach, bowel, or appendix. The approach combined surgery to remove visible tumors with heated chemotherapy drugs (mitomycin C and irinotecan) pumped directly …

This study looked at whether giving fewer antibiotics after appendix removal is safe and effective. 268 adults who had surgery for simple or complicated appendicitis took part. The goal was to see if a short course of antibiotics could reduce side effects without increasing compl…

This study tested a doctor-designed dose adjustment algorithm to prevent unplanned delays in FOLFOX chemotherapy for people with cancers of the colon, stomach, esophagus, and other digestive organs. 52 adults participated, and the goal was to see if the algorithm could keep treat…

This study looked at whether measuring a protein called calprotectin in the blood can help diagnose acute appendicitis. Researchers compared 74 patients with abdominal pain, some with confirmed appendicitis and others with non-specific pain. They measured calprotectin levels and …

This study tested whether a low-dose CT scan, enhanced with deep learning image reconstruction, can diagnose acute abdominal conditions as accurately as a standard CT scan. 246 adults with abdominal pain received both scans, and the low-dose version used less than 30% of the usua…

This study looked at whether the Appendistat Score (APS) can accurately identify patients with complicated appendicitis who need urgent surgery. Researchers reviewed records of 592 patients who had their appendix removed. They compared the APS score to the final lab results to se…

This study looked at whether giving fewer antibiotics after appendicitis surgery could lower the risk of antibiotic side effects without compromising patient safety. Over 650 adults who had surgery for simple or complicated appendicitis took part. The goal was to find the right b…

This study tested whether a numbing injection into the abdominal wall muscles (called a TAP block) can reduce pain for people with acute appendicitis waiting for emergency surgery. 105 adults in the emergency department received the block, and researchers measured how much pain m…

This study tested a 12-week online mind-body program for adults with chronic conditions like heart failure, cancer, and liver disease. The program included mindful movement, meditation, breathwork, and coping skills. Researchers measured changes in anxiety, depression, fatigue, a…

This study compared two types of nerve blocks—erector spinae plane (ESP) and quadratus lumborum (QL)—to see which provides better pain relief after appendix surgery in children aged 3-13. Sixty children received one of the blocks along with general anesthesia. Researchers measure…

This study tested whether using a cold therapy device on the belly after appendix removal helps control pain in children ages 7 and older. Half the kids got the cold pack plus usual care, the other half got usual care alone. Researchers measured pain scores, morphine use, and hos…

This study tested a newer, gentler type of keyhole surgery for removing the appendix. It uses lower gas pressure and smaller instruments than standard laparoscopy. Fifty adults with uncomplicated appendicitis took part, and the researchers measured their pain, recovery time, and …

This Phase 2 trial tested paltusotine, an oral drug, in 36 adults with carcinoid syndrome. The study looked at safety and how the body processes the drug at different doses. Participants were randomly assigned to 40 mg or 80 mg daily, with dose adjustments allowed. The goal is to…

This study compared two types of nerve blocks (TAP and ESPB) to standard pain medication (tramadol) for people with acute appendicitis in the emergency department. The goal was to see if these blocks could reduce pain before surgery and lower the need for opioids. The trial inclu…

This study looked at 250 children having laparoscopic surgery for appendicitis. It compared using low versus medium gas pressure in the belly during the operation to see if it affects pain the next day. The goal is to find ways to make children more comfortable after surgery.

This study compared two types of nerve blocks (erector spinae plane block vs. transversus abdominis plane block) for pain relief after laparoscopic appendix removal. 72 adults aged 18-50 participated. The goal was to see which block provides better pain control and fewer complica…

This phase 2 trial looked at whether adding acupuncture and acupressure to oral cryotherapy (sucking on ice chips) can reduce nerve pain caused by oxaliplatin chemotherapy in people with gastrointestinal cancers. 78 patients were split into two groups: one got cryotherapy alone, …

This study tested a new anesthesia drug called ciprofol in 86 children having laparoscopic surgery (like hernia repair or appendix removal). The goal was to see if it works as well as standard anesthesia for helping kids wake up and recover. Researchers measured how fast children…

This study tested a set of care steps called Enhanced Recovery After Surgery (ERAS) in 82 children who had their appendix removed. The steps included teaching families what to expect, avoiding tubes, and helping kids eat and move early after surgery. The goal was to see if this p…

This study looked at whether people with simple appendicitis can safely go home within 12 hours after surgery instead of staying overnight. Researchers followed 120 adults who had their appendix removed and checked if they were discharged quickly. The goal was to see if same-day …

This study tested whether aromatherapy (breathing lavender oil) or acupressure (gentle thumb pressure on specific points) could reduce pain and improve sleep in 100 children aged 6-12 after abdominal surgeries like appendix or hernia repair. The goal was to find simple, non-drug …

This completed study surveyed over 2,500 appendicitis patients to understand their satisfaction and regret after choosing either surgery or antibiotics. Researchers aim to use this information to design decision-support tools that help future patients make choices aligned with th…

This study aimed to create a detailed map of the cells in the human appendix and understand their genetic activity. Researchers analyzed appendix tissue from 5 patients undergoing colon cancer surgery. The goal was to learn more about the appendix's role in the immune system and …

This completed study tested whether a new biomarker called 'mass response' can predict how well a cancer therapy will work. Researchers collected tumor cells from 72 patients with various cancers through fluid drainage or biopsies. The goal was to see if this biomarker could guid…

This study looked at how emergency general surgery affects pregnant women and their unborn babies. Researchers planned to follow pregnant women who needed surgery for problems like appendicitis or gallbladder disease. The goal was to learn more about the safety of these surgeries…

This study looked at how sustainable laparoscopic appendectomy is by measuring its environmental impact (carbon emissions), cost, and health benefits. Researchers followed 63 patients in Chile who had surgery for acute appendicitis. The goal was to create a single score that comb…

This study observed 193 adults who had emergency laparoscopic appendix surgery for uncomplicated appendicitis. Researchers wanted to see how closely hospitals followed a specific recovery plan called RICA (an ERAS pathway) and whether early discharge within 24 hours was safe and …

This study looked back at 765 children with complicated appendicitis treated over ten years. Researchers wanted to see how well laparoscopic surgery works for different types of the condition, including cases with abscess or mass. The goal is to help doctors decide the best treat…

This study looked at how often emergency room doctors in Villavicencio, Colombia, use a tool called the Alvarado score to help diagnose appendicitis. The researchers surveyed 125 doctors to see if they knew about the score, used it, and wrote it down for patients with belly pain.…

This completed study tested a new method to see how well two different heated chemotherapy regimens work against pseudomyxoma peritonei, a rare abdominal cancer. Researchers injected a special form of chemotherapy (5-FU) before surgery to label newly made RNA in tumor cells. Afte…

This study looked at whether high bilirubin levels in the blood can help doctors quickly tell if appendicitis is complicated. Researchers studied 400 people who had their appendix removed. The goal was to see if this cheap, fast test could help doctors make better decisions about…

This study tested whether the Capillary Leak Index (CLI), a score based on routine blood tests, can predict which patients are at higher risk of dying after developing a serious abdominal infection following surgery. Researchers followed 100 critically ill adults in the ICU for 2…

This completed trial looked at 190 people having laparoscopic appendix removal. It compared closing the appendix stump with a hand-tied knot versus a plastic clip. The goal was to see which method leads to fewer problems like infection or slow bowel recovery within 15 days after …

This study looked at different methods for closing the appendix stump after surgery for complicated appendicitis. Researchers compared how often leaks happened with each technique. The study included 666 adults aged 18 and older with complicated appendicitis.