Cecal disorder

This early-stage trial tests a drug called ACM-CpG, which is injected directly into the abdomen to stimulate the immune system against cancer. It includes 24 adults with colorectal or appendix cancer that has spread to the lining of the abdomen or caused fluid buildup. The main g…

This study tests whether an intestinal or multivisceral transplant can help people with a rare abdominal cancer called pseudomyxoma peritonei (PMP) that cannot be removed by surgery. Twenty participants will receive the transplant and be followed for 12 months to see if they surv…

This study tests whether treating children with uncomplicated appendicitis using antibiotics alone works as well as surgery. About 724 children aged 5 to 15 will be randomly assigned to receive either antibiotics or an operation. The goal is to see if the antibiotic approach lead…

This early-stage trial tests a technique called PIPAC, which turns a chemotherapy drug (mitomycin C) into a mist and sprays it directly onto cancer spread inside the abdomen. It is for people with advanced gastrointestinal cancers that cannot be removed by surgery. The main goal …

This trial compares a one-day course of antibiotics after appendix surgery to the standard five-day course in 200 children and adults with uncomplicated appendicitis. The goal is to see if the shorter course prevents infections just as well, while reducing side effects and costs.…

This early-phase study tests a new drug combination (PX plus nab-paclitaxel) given directly into the abdomen for people with a type of advanced cancer that has spread to the lining of the belly. The main goal is to find a safe dose and check for side effects. About 22 adults with…

This early study tests a new robotic surgical system (Revolve) in 3 adults with simple appendicitis who are already scheduled for appendix removal. The robot helps the surgeon work more precisely during minimally invasive surgery. The main goal is to see if the device can safely …

This study tests whether a step-by-step plan to manage body temperature during a long surgery can lower the chance of postoperative delirium (sudden confusion). The surgery is for a rare abdominal tumor called pseudomyxoma peritonei and involves heated chemotherapy. The trial wil…

This study will compare two methods of closing the skin after open appendix surgery: standard interrupted stitches versus a continuous stitch under the skin plus a small drain. The goal is to see which method leads to fewer wound infections and better healing. About 100 people ag…

This phase 3 trial tests a new method called PIPAC that delivers chemotherapy as a pressurized mist directly into the abdomen during a minimally invasive procedure. It compares this approach plus standard intravenous chemo (FOLFIRI) to standard chemo alone for people with appendi…

This study tests a new, non-surgical treatment called ERAT for mild appendicitis. Instead of removing the appendix, doctors use a flexible tube through the colon to clear the blockage and infection. The trial will compare ERAT to standard laparoscopic surgery in 376 adults to see…

This study tests a simple 10-item checklist that parents can use during a video call to help doctors figure out if a child's belly pain is appendicitis. About 1,500 children aged 3 to 16 with stomach pain will try the checklist with a medical student, then get standard care. The …

This study compares two ways of adjusting the air cushion (cuff) on the breathing tube used during general anesthesia in children having laparoscopic appendectomy. One group uses the standard finger-palpation method, while the other uses a pressure sensor to keep the cuff within …

This study will see if using a Garmin smartwatch to continuously track heart rate, breathing rate, and oxygen levels can help doctors spot early warning signs in hospitalized children in Ghana. About 250 children with traumatic injuries or after appendix surgery will wear the wat…

This pilot study looks at whether it is safe to stop giving antibiotics after surgery for a burst (perforated) appendix. About 100 adults will be randomly assigned to receive either antibiotics or no antibiotics after their operation. The main goal is to see if a larger study is …

This observational study will examine lymph nodes from the ileum mesentery in 406 people undergoing surgery for right-sided colon cancer. Researchers want to learn where cancer spreads in these nodes to help surgeons decide how much tissue to remove. Participants will be followed…

This study will look at 150 infants and children aged 1 month to 4 years who are admitted to a hospital gastroenterology unit with a gastrointestinal disease. The goal is to find out how common electrolyte disturbances (like low sodium or potassium) are in these children. By meas…