Anaerobic bacteria infectious disease

This study tests a hexavalent vaccine that protects against six diseases, including polio, but uses a lower dose of the inactivated polio vaccine (IPV). The goal is to see if this reduced-dose version works as well as the standard full-dose vaccine in infants. Around 1,500 health…

This completed study tracked over 10,000 people in Thailand who received the Boostagen® vaccine, which protects against tetanus, diphtheria, and whooping cough. Healthcare workers reported any side effects to see how safe the vaccine is in everyday use. The study also looked at p…

This completed study checked the safety of the Hexaxim vaccine in 713 infants aged 2 months and older in South Korea. Researchers tracked side effects like injection site reactions, fever, and crying after routine vaccination. The goal was to confirm the vaccine's safety in every…

This study tested a new vaccine called BK1310 in 370 healthy infants to see if it safely protects against several serious diseases: Hib, diphtheria, pertussis, tetanus, and polio. The vaccine was compared to existing vaccines. The goal was to check how well the infants' immune sy…

This study tested a new vaccine called BK1310 in 267 healthy infants to see if it protects against tetanus, diphtheria, pertussis, polio, and bacterial meningitis as well as existing vaccines. Infants received three doses, and researchers measured their immune responses. The goal…

This study tested a booster dose of the DTaP vaccine (BK1301) in 446 adolescents aged 11-12 who had already received the standard childhood series. The goal was to confirm the vaccine boosts immunity against diphtheria, tetanus, and pertussis (whooping cough) safely. Results show…

This study tested a new combination vaccine called Shan6™, which protects against six diseases (diphtheria, tetanus, whooping cough, hepatitis B, Hib, and polio) in healthy infants and toddlers in Thailand. The trial involved 460 participants and compared Shan6™ to a similar 5-in…

This study looks at whether giving the Tdap vaccine every 3 months for a year is safe for healthy plasma donors. Normally, this vaccine is given once every 10 years. The goal is to see if more frequent vaccination produces high levels of tetanus antibodies in the plasma, which co…

This study tested a single booster dose of a recombinant botulinum vaccine in 25 healthy adults who had already been vaccinated against botulism for work. The goal was to see if the booster safely raises their antibody levels enough to donate plasma for making BabyBIG, a treatmen…

This completed Phase 1/2 trial tested a new lab-made antibody called SNA02-48 for treating tetanus in 255 Chinese adults. The study compared SNA02-48 to the standard treatment (human tetanus immunoglobulin) to see if it is safe and how well it works. The goal is to find a more re…

This study tested whether giving pantoprazole (a stomach acid reducer) to critically ill ICU patients prevents stress ulcers and reduces death. Over 3,300 adults at high risk were randomly assigned to receive pantoprazole or a placebo daily while in the ICU. Researchers tracked d…

This study looked at whether giving the antibiotic vancomycin helps cancer patients who have diarrhea and a positive screening test for C. difficile but a negative toxin test. Only 9 patients were enrolled, far fewer than planned. Researchers measured changes in C. difficile leve…

This study tested whether eating less fat and more fiber can reduce the chance of a repeat Clostridioides difficile infection in cancer patients. Eight participants with leukemia, lymphoma, or other cancers followed a specific diet. Researchers tracked diarrhea and measured C. di…

This study tested whether taking capsules containing healthy gut bacteria could help clear drug-resistant germs (including C. difficile) from the intestines of 42 hospitalized adults who needed at least 7 days of antibiotics. Participants received either the bacteria capsules or …

This phase 2 study tested an experimental antibiotic called CRS3123 against the standard treatment vancomycin for Clostridioides difficile infection (C. diff). 43 adults with a first episode or first recurrence of C. diff took either CRS3123 or vancomycin for 10 days. The main go…

This study tested fecal microbiota transplant (FMT) in 24 adults with recurrent Clostridium difficile infection (C. diff) that didn't get better with standard antibiotics. FMT involves placing healthy donor stool into the patient's colon to restore good bacteria. The goal was to …

This study tested whether adding the drug bezlotoxumab to standard treatment could prevent serious outcomes in people with a severe C. diff infection. Researchers used a special score to identify 44 high-risk patients. The goal was to see if the drug reduced organ failure, infect…

This study tests a new delayed-release metronidazole capsule designed to release the drug directly in the colon, where C. diff bacteria live. 18 healthy adults will receive a single dose of either the new capsule or the standard tablet to compare how much drug reaches the colon v…

This study looked at whether giving hospital-level care to acutely ill adults in their own homes in rural areas works well. 160 people with various conditions like infections, heart failure, or COPD took part. The goal was to see if this approach could lower costs and help patien…

This small pilot study tested a drug called 3,4-diaminopyridine (FIRDAPSE) in 3 people with severe botulism who needed a ventilator to breathe. The goal was to see if the drug could improve nerve signals and breathing. Because only 3 people took part, the results are very prelimi…

This study tested an experimental drug called TNM002 in 240 healthy Chinese adults to see if it can protect against tetanus as well as the standard treatment. Participants received a single injection of TNM002 at different doses, the standard tetanus antibody, or a placebo. The m…

This study looked at how well a new, quick finger-prick test (LumiraDx CRP) measures CRP levels compared to a standard lab test. CRP is a marker of infection, inflammation, or tissue injury. 79 adults with symptoms of these conditions took part. The goal was to see if the new tes…

This early study tested whether a special PET scan using a radioactive form of vitamin B9 (11C-PABA) can help doctors see infections deep inside the body. Researchers scanned 13 healthy people and patients with known or suspected infections. The goal was to see if this method can…

This trial evaluates whether a hospital-based remedial vaccination strategy can improve Tdap-IPV (tetanus, diphtheria, pertussis, polio) vaccination rates in adults aged 65 and older in the Sarthe region of France. Participants are randomly assigned to receive either the remedial…

This study tested an experimental vaccine (G03-52-01) in 622 healthy adults to see if it could safely protect against botulinum toxin, the poison that causes botulism. Participants received either the vaccine or a placebo, and researchers measured side effects and immune response…

This study tested whether extending standard vancomycin treatment for C. diff infection with a 2-week taper (lowering the dose gradually) reduces the chance of the infection returning. 263 adults who had a first episode or first recurrence of C. diff were randomly assigned to rec…

This study tested whether combining a fecal microbiota transplant (FMT) with the drug bezlotoxumab could prevent repeat Clostridium difficile infections in people with inflammatory bowel disease (IBD). Sixty-one adults with at least two prior C. diff infections were randomly assi…

This study tested whether a probiotic called Bifidobacterium breve PRL2020 could reduce stomach issues like diarrhea in 121 children aged 3-12 who were taking amoxicillin antibiotics. The children took the probiotic alongside their antibiotic treatment. The goal was to see if it …

This study reviews the medical records of people who were hospitalized in French intensive care units (ICUs) for severe botulism poisoning. Botulism is a rare but serious illness caused by a toxin that can paralyze muscles. The goal is to describe what happened to these patients,…

This study looks at how a single dose of the antibiotic levornidazole is processed by the body in people with moderate or severe kidney impairment compared to healthy volunteers. Researchers will measure drug levels in the blood and urine, and monitor safety. The goal is to under…

This study looked at 335 adults hospitalized with bacterial infections to see if taking NSAIDs (like ibuprofen) before admission made their infections more severe. Researchers compared those with complicated infections (abscesses, needing surgery) to those with simpler infections…

This study looked at how many people with cirrhosis in French general hospitals were vaccinated against diseases like hepatitis, flu, and COVID-19. Researchers surveyed 742 patients to see if they were up to date on their shots. The goal was to find gaps in vaccination coverage s…

This study aimed to find the best dose of the antibiotic ceftazidime for critically ill children with severe burns. Researchers took blood samples from 3 children to measure how the drug moves through the body. The goal was to learn how to personalize dosing to improve treatment …

This early-phase study tested a single dose of the antibiotic omadacycline (Nuzyra) in 23 children aged 8 to 17 who were hospitalized with bacterial infections. Researchers measured how the drug moved through the body and checked for side effects. The goal was to gather safety an…

This early-stage study tested a single dose of AZD5148, a potential treatment for C. difficile infection, in 16 healthy Japanese adults. The main goal was to see if the drug is safe and how the body processes it. Participants received either the drug or a placebo by injection and…

This study tested a new imaging technique using a radioactive tracer called 11C-trimethoprim to see how it spreads in the bodies of 16 adults with suspected bacterial infections. Participants had PET/CT scans to track the tracer over time. The goal was to learn how the tracer beh…

This study looked at whether exposure to PFAS chemicals (found in some water supplies) can weaken the body's immune response to the tetanus and diphtheria booster vaccine. Twenty adults from a community with known PFAS exposure received the vaccine and had blood and saliva sample…

This study looked at how well stool and blood samples could be collected from 7 adults with an active C. diff infection. Researchers wanted to see if the collection, shipping, and testing methods worked smoothly. Participants also filled out questionnaires about their symptoms. T…

This study looked at 156 critically ill patients to find out what factors help achieve the right levels of beta-lactam antibiotics in the blood. Researchers collected clinical data and used therapeutic drug monitoring to see which patients reached target concentrations. The goal …

This early-stage study tested a single dose of a new drug, AZD5148, in 84 healthy adults to see if it is safe and how the body processes it. Participants received the drug either as a shot into a muscle or a vein, or a placebo. The study did not aim to treat any disease, only to …

This study tested special wearable pumps (elastomeric pumps) to give antibiotics through a drip to hospital patients. Nine adults with bacterial infections took part to see if the pumps are safe, easy to use, and could save time and money compared to traditional methods. The goal…