Acute pancreatitis

This study tested whether analyzing a patient's DNA and RNA could help doctors pick the right drug for inflammatory diseases that don't fit standard categories. 32 adults with at least two affected organs (including skin) received one of six targeted therapies based on their mole…

This study tested an experimental drug called CM4620-IE in 21 people with severe pancreatitis that caused body-wide inflammation (SIRS). The goal was to see if the drug is safe and to find the best dose for future studies. Participants received the drug plus standard care or stan…

This study looked at whether using low-acid contrast media (dye) during ERCP can lower the chance of developing pancreatitis afterward. Researchers reviewed records of nearly 4,000 patients from five hospitals. They compared patients who received low-acid contrast media to those …

This study tested whether tranexamic acid, a drug that helps blood clot, can lower the chance of infection after gastrointestinal surgery. Over 3,300 adults at higher risk for complications took part. The goal was to see if the drug reduces surgical site infections compared to a …

This study tested a drug called Auxora in 216 people hospitalized with acute pancreatitis and systemic inflammatory response syndrome (SIRS), a serious body-wide inflammation. Participants received either Auxora or a placebo daily for three days. The main goal was to see if Auxor…

This study looked at 50 adults with infected, walled-off dead tissue in the pancreas from severe pancreatitis. Researchers compared doing endoscopic removal right away versus waiting until needed. The goal was to see which approach leads to complete recovery and fewer complicatio…

This study tested whether injecting epinephrine around the bile duct opening, combined with a standard rectal anti-inflammatory drug, could reduce pancreatitis after ERCP—a common procedure to treat bile duct blockages. Over 500 adults with a first-time ERCP took part. The goal w…

This study tested two types of endoscopes used in ERCP, a procedure to treat bile duct and pancreas problems. One scope had a single-use plastic cover on its tip, while the other was a standard reusable scope. Researchers compared how well each worked and how often complications …

This study looked at how well a new, quick finger-prick test (LumiraDx CRP) measures CRP levels compared to a standard lab test. CRP is a marker of infection, inflammation, or tissue injury. 79 adults with symptoms of these conditions took part. The goal was to see if the new tes…

This study tested whether a low-dose CT scan, enhanced with deep learning image reconstruction, can diagnose acute abdominal conditions as accurately as a standard CT scan. 246 adults with abdominal pain received both scans, and the low-dose version used less than 30% of the usua…

This study looked at new markers in blood and urine to detect and predict the severity of drug-associated acute pancreatitis in adults. Researchers compared these markers in 175 patients with drug-induced pancreatitis, other pancreatic diseases, and healthy volunteers. The goal i…

This early study tested a new radioactive tracer called 18F-FDS in 16 people with suspected bacterial or fungal infections. The tracer is designed to light up infection sites on PET/CT scans, helping doctors see exactly where an infection is. The goal was to check how the tracer …

This study tested whether giving rectal indomethacin (an anti-inflammatory drug) along with extra fluids before an ERCP procedure could prevent pancreatitis, a painful complication. The trial included 60 patients who needed ERCP. The goal was to see if this simple, low-cost appro…

This study tested whether taking oral N-Acetyl cysteine before an ERCP procedure could prevent pancreatitis as well as the standard treatment, rectal diclofenac. Forty-six adults at risk for pancreatitis after ERCP received one of the two drugs. The goal was to see which drug bet…

This study looked at 192 children having an ERCP procedure to see which drug—rectal indomethacin or IV ketorolac—better prevents post-ERCP pancreatitis. Both are anti-inflammatory medicines given before the procedure. The goal is to find the most effective option for kids.

This study looked at whether giving more IV fluids (aggressive hydration) during an ERCP procedure can prevent pancreatitis, a common complication. 126 adults having their first ERCP were randomly assigned to receive either standard or extra fluids. The goal was to see if extra f…

This study tested whether rinsing the duodenal papilla with cold (3°C) sterile saline right after an ERCP procedure can lower the risk of post-ERCP pancreatitis. 900 adults in Colombia were randomly assigned to receive the cold saline rinse or standard care. The main goal was to …

This study tested whether a procedure called ERCP with sphincterotomy can lower the risk of repeat pancreatitis attacks in people with pancreas divisum, a condition where the pancreas ducts don't join normally. 181 adults who had at least two pancreatitis episodes were randomly a…

This study tested a 12-week online mind-body program for adults with chronic conditions like heart failure, cancer, and liver disease. The program included mindful movement, meditation, breathwork, and coping skills. Researchers measured changes in anxiety, depression, fatigue, a…

This study tested a non-invasive device that stimulates a nerve in the ear (taVNS) to see if it can calm inflammation and improve gut function in people with acute pancreatitis. Sixty adults with early-stage pancreatitis received either the real stimulation or a sham device. The …

This study tested whether using forceps to help guide a tube into the bile duct during an ERCP procedure makes the process easier and reduces the chance of pancreatitis afterward. 152 patients were randomly assigned to either standard cannulation or forceps-assisted cannulation. …

This completed study looked at how the social networks of caregivers affect their stress and health when caring for someone with an inherited disease. Researchers surveyed over 680 participants, including family members and formal caregivers, to understand caregiving burden and s…

This study reviewed medical records of 148 adults admitted to the ICU with severe acute pancreatitis. The goal was to find risk factors for infected pancreatic necrosis, a serious complication that raises the risk of death. By identifying these factors, doctors hope to diagnose a…

This completed observational study at Uşak University examined 150 adults hospitalized in the endocrinology department. Researchers measured breathing, muscle strength, pain, fatigue, sleep quality, physical activity, balance, and nerve function. The goal was to better understand…

This completed study looked at 141 people with acute pancreatitis to understand how blood clotting changes during the illness. Researchers took blood samples over several days and will analyze them for markers that might predict whether the disease becomes mild, moderate, or seve…

This study looked at how emergency general surgery affects pregnant women and their unborn babies. Researchers planned to follow pregnant women who needed surgery for problems like appendicitis or gallbladder disease. The goal was to learn more about the safety of these surgeries…

This study looked at 445 patients with mild acute biliary pancreatitis to compare having gallbladder removal surgery during the same hospital stay versus waiting for a later date. The goal was to see which approach leads to fewer repeat hospital visits for gallstone-related probl…