Vastra Gotaland Region

Researchers are testing whether adding stereotactic ablative radiotherapy (SABR) to standard systemic therapy helps people with oligometastatic breast cancer, meaning cancer that has spread to only a few sites. The trial enrolls adults with 1 to 5 metastases in up to two organs. …

This study tests whether one dose of the immunotherapy drug pembrolizumab, given before standard surgery, can shrink or eliminate tumors in people with stage IIb/c melanoma. About 30 adults with thick melanomas that haven't spread to lymph nodes will receive either pembrolizumab …

This study tests a program called LAGOM designed to improve heart health and quality of life for people with psychotic disorders. 644 adults from six clinics in Gothenburg will either receive the LAGOM program or standard care. The program includes regular check-ups, motivational…

This study tests whether a detailed, personalized care plan—including diet, exercise, and counseling—can reduce hospitalizations and improve quality of life for people with COPD who have recently been hospitalized. About 110 adults aged 40 and older who smoke or used to smoke wil…

This study tests whether adding targeted, high-dose radiation to standard drug therapy (chemotherapy or immunotherapy) helps people with non-small cell lung cancer that has spread to up to 5 spots live longer. About 240 participants will be randomly assigned to receive either sta…

This Phase 3 trial tests whether adding lomustine to standard temozolomide chemotherapy improves survival for people with newly diagnosed glioblastoma that has a specific genetic marker (MGMT methylated). About 200 adults aged 18-70 will be randomly assigned to receive either the…

This study tests whether a special balloon coated with the drug paclitaxel (Optilume) can prevent urethral strictures from returning better than a standard balloon. About 230 adults with a recurrent stricture after at least one prior treatment will be randomly assigned to one of …

This study compares having one laser treatment versus several sessions for a serious diabetic eye condition that can cause blindness. Researchers want to see which approach is safer and works better. The study will involve 40 adults with type 1 or type 2 diabetes who have this ey…

This study compares two treatments for arm spasticity (stiff, tight muscles) caused by stroke, spinal cord injury, or brain injury. Thirty adults will first receive Botox injections, then undergo tendon-lengthening surgery a few months later. Researchers will measure how well eac…

This study looks at whether a physiotherapist can accurately diagnose subacute knee injuries (lasting 1 week to 3 months) using a video consultation instead of an in-person exam. Researchers will compare three types of assessments: video-based, in-person without special knee test…

This study tests a new camera system that measures vital signs like pulse, blood pressure, and temperature without touching the body. The goal is to see if it works as well as standard devices, which require physical contact and can spread infections. About 860 adults visiting he…

This study tests a brief therapy program (ASSIP-OA) designed to prevent suicide in adults aged 65 and older who have recently attempted suicide or had serious suicidal thoughts. About 132 participants will receive either the program plus usual care, or usual care alone. Researche…

This study tests a digital program called WOMENinMOTION for pregnant women with or without pelvic girdle pain. The program provides pain education, exercise videos, and tips to stay active, with extra physiotherapy if needed. Researchers will track 592 women for up to 2 years aft…

This study tests an accelerated version of a brain stimulation treatment called iTBS for depression. Instead of daily sessions over weeks, patients receive 30 short sessions in just 5 to 14 days. Researchers will track mood changes over six months to see if this faster approach w…

This study tests whether a person-centred care (PCC) programme, delivered by phone and online, can help people with Graves' disease feel better mentally and return to work. 220 adults with first-time Graves' disease will be randomly assigned to receive either usual care or usual …

This study tests whether a special course on mental fatigue can help people with Graves' disease who struggle with ongoing brain tiredness, trouble focusing, and memory issues. About 96 adults aged 18-72 with stable thyroid levels will either take the course plus standard care or…

This study tests whether a tailored physical activity program can improve quality of life and overall health in people who had surgery for a non-functioning pituitary adenoma. Participants will be randomly assigned to receive an individualized exercise plan from a physiotherapist…

Many people with Graves' disease keep feeling mentally drained even after treatment brings their thyroid hormones back to normal. Researchers suspect the immune system may be attacking the brain in a way that standard thyroid tests miss. The study follows 430 people newly diagnos…

This study looks at how different levels of positive end-expiratory pressure (PEEP) on a ventilator affect the diaphragm and lungs in ICU patients with respiratory failure. Twenty-five adults on pressure support ventilation will each receive low, medium, and high PEEP for short p…

This study looks at whether providing acute medical care at home for people aged 75 and older is as effective as sending them to the emergency department. Researchers will compare health outcomes, including hospital stays and death rates, between those who received home-based car…

This observational study will follow 50 children aged 5 to 8 with non-progressive congenital ataxia, a rare condition that affects movement and coordination. Researchers will use detailed exams, brain scans, and genetic testing to better understand the disorder and its impact on …

This study watches 300 premature babies who need surfactant—a natural substance that helps their lungs stay open. Doctors will use different methods to give the medicine, like a thin tube or a mask, and track which babies need a breathing machine or more medicine within 72 hours.…

This study aims to see if a submaximal bike test, called the Ekblom-Bak test, gives consistent results when repeated in people with hip or knee osteoarthritis. Forty patients will take the test twice, one to two weeks apart. The goal is to determine if this test can be reliably u…

This study will check how often the sensors used to measure blood pressure in intensive care patients are not positioned correctly. Such errors can lead to wrong readings and possibly inappropriate treatments. Researchers will observe 60 adult ICU patients on ventilators and vaso…

This study will follow 300 people with aortic stenosis who are scheduled for a TAVI procedure to replace their heart valve. Researchers will use heart scans, blood tests, and checkups to measure how the heart's condition changes over time. The goal is to better understand short- …

This study follows 380 women for a year after vaginal delivery to see how pelvic floor muscles and tissues recover. It also tests whether early, personalized pelvic floor exercises can improve symptoms like urine leakage and pelvic organ prolapse compared to standard care. Partic…

This study is looking for 340 people with suspected giant cell arteritis (GCA), a condition that causes inflammation in blood vessels and is usually treated with long-term steroids. The goal is to find better ways to predict who will have relapses and to monitor the disease using…

This study tests whether having nurses or pharmacists, instead of doctors, do the first assessment for a sore throat can reduce unnecessary antibiotic use. Researchers will compare how often each type of health professional follows official guidelines. The goal is to see if chang…

This study tests a magnetic tracer and clip to mark lymph nodes before chemotherapy in breast cancer patients. The goal is to see if this method can reliably find the sentinel lymph node during surgery after chemo. About 459 adults with breast cancer will take part. The approach …

This study follows 400 patients who have had urologic cancer surgery with lymph node removal to see how often they develop lymphedema (leg swelling). Researchers will use questionnaires and special devices to measure swelling and tissue fluid over two years. The goal is to better…

This study talks to parents of 12 to 15 children with functional constipation to learn about their experiences with physical activity. The goal is to understand if exercise might help, since there is little research on this topic. The results could lead to better care and possibl…

This study looks at women aged 50 and older who have visible blood in their urine along with a bladder infection. Researchers want to find out if these women really need to undergo invasive tests like cystoscopy and CT scans to check for bladder or kidney cancer. By following 300…

This study is for people with diabetic macular edema, a condition that causes vision loss. Researchers want to see if certain substances in the blood and patterns on eye scans can predict how well a patient will respond to two common treatments: anti-VEGF injections or a dexameth…

This study tests whether starting gentle exercises with a special brace 3 weeks after peroneal tendon surgery leads to less pain and better function than the standard 6 weeks in a cast. Fifty adults in Sweden who have surgery for a torn peroneal tendon will be randomly assigned t…