Vastra Gotaland Region

This early-stage trial tests whether immune cells taken from a patient's own tumor (TIL) can be safely given directly into the liver or through a vein to fight metastatic melanoma. 18 adults with advanced uveal or cutaneous melanoma that has spread will receive TIL along with che…

Researchers are testing a treatment for melanoma that has spread to the liver. They collect tumor-infiltrating lymphocytes, a type of immune cell, from the patient's own tumor and grow them in the lab. Before returning the cells, they use a technique called percutaneous hepatic p…

Pulse oximeters, which clip onto a finger to estimate blood oxygen levels, can be less accurate when blood flow to the fingers is poor, a common issue in critically ill patients. This trial tests whether warming the hand and lower forearm for 15 minutes improves the accuracy of t…

This trial tests whether a first physiotherapy appointment done over video works as well as a traditional in-person visit for people with muscle, bone, or joint pain. Participants will be randomly assigned to either a video or in-person consultation and followed for up to two yea…

This study tests a 26-week video coaching program to help adult survivors of childhood cancer eat better and exercise more. The goal is to improve their quality of life and reduce long-term health risks like heart disease. About 900 participants will be randomly assigned to recei…

This study tests whether a targeted chemoradiotherapy can completely eliminate early-stage rectal cancer, allowing patients to avoid surgery and keep their rectum. 90 adults with small, localized tumors will either receive standard surgery or the new treatment followed by close m…

This study will enroll 144 children aged 9-13 with a class II malocclusion (overjet of 6 mm or more) to compare three early orthodontic appliances (headgear-activator, twin block, and Invisalign mandibular advancement) against a control group that receives later fixed braces. Res…

This study tests a Nordic version of the Crohn's Disease Exclusion Diet in 30 children aged 6-18 with mild-to-severe Crohn's disease. The diet avoids inflammatory foods and gradually reintroduces unprocessed items over 20 weeks. Researchers will measure remission rates, diet adhe…

This study tests whether giving dry plasma to people with massive bleeding before they reach the hospital can improve survival. Researchers will compare dry plasma to standard fluids in 650 adults with signs of bleeding shock. The main goal is to see if more people survive the fi…

This phase 3 trial tests whether a magnetic tracer (Magtrace) works as well as the standard radioactive dye plus blue dye for finding sentinel lymph nodes in people with melanoma. About 254 adults having surgery for melanoma will receive both tracers and be randomly assigned to h…

This study tests whether a gamified training program for doctors, plus an AI tool that analyzes ear drum images, can improve the accuracy of diagnosing ear infections (otitis media). About 200 patients with ear symptoms will be seen by doctors who either received the training or …

This study tests whether adding shockwave therapy to a tailored exercise program reduces pain and improves function in people with Achilles tendon pain. Two hundred adults with pain in the mid-portion or insertion of the tendon will be randomly assigned to exercise alone or exerc…

This study tests whether a 12-week program of high-intensity interval training and strength training can improve heart and metabolic health in people with psoriatic arthritis. Researchers will also measure changes in fitness, pain, fatigue, and quality of life. The trial plans to…

This study investigates whether changes in serum phosphate, a blood electrolyte, are linked to respiratory quotient, a measure of how the body uses energy, in critically ill patients during their first week in intensive care. The goal is to see if a rising respiratory quotient co…

In intensive care, indirect calorimetry measures oxygen use and carbon dioxide production to estimate energy needs for nutrition. This study tests whether changing positive end-expiratory pressure (PEEP), a common ventilator setting, alters those measurements. Twenty critically i…