University Hospital, Brest

This phase 3 trial tested whether abatacept, a drug that calms the immune system, can control polymyalgia rheumatica (a painful inflammatory condition) without the need for long-term steroids. Thirty-four adults with early disease received either abatacept or a placebo for 12 wee…

This study tested an early, intensive therapy program called HABIT-ILE in 36 preschool children (ages 1-4) with bilateral cerebral palsy. The therapy focuses on coordinated use of both hands and legs through structured activities. Researchers measured changes in gross motor funct…

This study looked at whether taking a fast-acting insulin (Insulin Aspart) before or after meals makes a difference in blood sugar control for people with type 1 diabetes who use an insulin pump. Twenty-two adults participated, and their blood sugar was tracked continuously for 1…

This study tested whether using a non-invasive ventilation machine for at least 7 days before lung cancer surgery could reduce lung and heart complications. The trial included 300 patients with lung cancer who also had breathing problems, obesity, or heart failure. The goal was t…

This study compared two surgical methods to repair damaged knee cartilage: a newer cell-based technique (autologous chondrocyte implantation) and a standard bone-graft method (mosaicoplasty). 58 adults aged 18-50 with isolated knee lesions took part. The goal was to see which app…

This study tested a personalized approach to giving fluids to people with septic shock, using small fluid challenges to guide treatment. The goal was to reduce organ failure by avoiding both too little and too much fluid. Over 500 adults in intensive care took part, and the appro…

This study tested a new DNA-based technique called shotgun metagenomics to see if it can diagnose chronic infections in artificial joints better than standard lab cultures. Researchers took samples from 144 adults undergoing surgery for a suspected joint infection. The goal was t…

This study tested whether a French version of the HSCL25 questionnaire can help general practitioners diagnose depression more accurately. Over 1,100 adults visiting their primary care doctor took the questionnaire, and their scores were compared to a standard diagnostic intervie…

This study looked at 45 patients whose HPV tests came back negative but had a late signal in the raw data. Researchers wanted to see if these late signals might actually indicate early cervical cell changes. By comparing different lab methods, they aim to improve how we interpret…

This study tested two new devices that automatically measure vision in children aged 6 to 16. The devices use special lenses that adjust themselves, avoiding the need for eye drops that dilate the pupils. Researchers compared the results from 43 children to the standard dilation …

This study tested whether a special PET/CT scan (V/Q PET/CT) can accurately diagnose pulmonary embolism (a blood clot in the lungs) compared to the standard CT scan. About 100 adults with suspected first-time clots took part. The goal was to see how sensitive and specific the new…

This study tested a new CT scan method that creates a map of blood flow in the lungs to diagnose pulmonary embolism (blood clots). Researchers compared it to the standard SPECT scan in 30 patients. The goal was to see if the new method is as accurate, while being faster and safer…

This study looked at whether using intermittent pneumatic compression (IPC) devices on the legs, along with elastic stockings, reduces blood clots better than stockings alone in intensive care patients who are at high risk of bleeding. About 408 adults in ICUs with conditions lik…

This study tested whether adding a special breathing exercise (inspiratory muscle training) to a standard 3-week pulmonary rehab program helps reduce shortness of breath more than rehab alone. It included 38 COPD patients with normal breathing muscle strength. The goal was to see…

This Phase 3 trial tested the drug oxybutynin in 62 adults with excessive sweating (hyperhidrosis). Participants took either oxybutynin or a placebo, starting at a low dose and increasing gradually. The study measured how well the drug reduced sweating and improved quality of lif…

This study tested whether methoxyflurane (Penthrox®), a pain-relief inhaler already used for trauma, can quickly reduce moderate to severe dental pain in adults. 190 participants received either methoxyflurane or a placebo alongside standard care. The goal was to see if pain drop…

This study tested a smartphone app called "Bouge" to see if it could help pregnant women increase their daily physical activity. About 250 women in early pregnancy used the app to try to walk an extra 2,000 steps each day. The study also looked at whether the app improved sleep, …

This study tested whether LED light therapy can help people with sensitive skin who do not have other skin conditions like rosacea or acne. Thirty adults with sensitive skin received the treatment. The goal was to see if symptoms like pain and itching improved.

This study tested two oral medications, aprepitant and hydroxyzine, to see which better reduces severe itching triggered by water contact in people with myeloproliferative neoplasms (a type of blood cancer). 63 participants who had persistent itching rated 5 or higher on a 10-poi…

This study looked at two simple, drug-free ways to ease pain in newborns during a needle stick: breastfeeding or a sugar solution. Researchers measured brain activity and stress levels in 114 healthy, full-term breastfed babies. The goal was to see which method works better for c…

This study tested whether giving two types of light therapy (intense pulsed light and low-level light therapy) before laser eye surgery can help prevent dry eyes afterward. 62 people who were already scheduled for laser vision correction took part. The goal was to see if these tr…

This study tested two methods to strengthen leg muscles in 102 people with severe COPD: electrical stimulation (using pads on the skin) and stationary cycling. Both were part of a 3-4 week hospital rehab program. The goal was to see which better improves leg function and exercise…

This study tested a portable ultrasound device to measure pelvic tilt in 33 people: 3 healthy volunteers and 30 patients before and after hip replacement. The goal was to see if the device gives consistent measurements between different operators and to describe how pelvic tilt c…

This completed study with 247 adults aged 18 to 50 explored how body measurements, shoulder muscle strength, and core endurance influence the Closed Kinetic Chain Upper Extremity Stability Test (CKCUEST) score. Participants performed a push-up-like movement touching one hand to t…

This completed study looked at 70 patients with myeloma or lymphoma who needed stem cell transplants. Researchers compared two drugs, Zarzio and Granocyte, used to stimulate stem cell production before collection. The goal was to see if one drug led to better stem cell grafts. Si…

This study looked at 49 kidney transplant patients to see how two different induction therapies—thymoglobulin and basiliximab—affect B cells, a type of immune cell. Researchers compared the B cell profiles between the two groups and with data from patients who had chronic antibod…

This study looked at how deep dives (60-120 meters) using closed-circuit rebreathers affect divers' lungs. Twenty experienced divers had lung tests, ultrasounds, and blood samples before, right after, and the day after a dive. The goal was to measure changes in lung capacity and …

This study looked at whether performing two 6-minute walk tests at the end of a pulmonary rehabilitation program provides a more accurate measure of exercise ability in people with COPD. Researchers compared the distance walked in the first and second tests to see if there was a …

This study aimed to find the normal size of the ulnar nerve at the elbow using ultrasound in 50 healthy adults without any nerve problems. The goal was to establish a standard measurement to help doctors better diagnose ulnar nerve issues. Researchers measured the nerve's surface…

This study looked at whether a simple six-minute stepper test can show how well people with COPD improve their exercise ability during a 3-week pulmonary rehabilitation program. Researchers measured the number of steps before and after rehab in 72 patients. The goal was to see if…

This study measured how body size and physical activity affect a shoulder stability test called the CKCUEST. Eighty-two healthy young adults did a push-up-like movement for 15 seconds. The goal was to see if factors like height, weight, and exercise habits change the test results…

This study tested whether it is practical for caregivers to send text messages to patients after a suicide attempt. 15 adults who had attempted suicide and their designated caregivers took part. The goal was to see if patients and caregivers found this SMS follow-up acceptable an…

This study looked at whether a special PET/CT scan, done within two months after treatment, helps doctors make better decisions for patients with advanced cervical cancer. Researchers compared what doctors would decide without the scan versus with it. The study involved 40 patien…

This completed study looked at 200 women who have had at least one child. Researchers measured the angle of the uterus when the bladder was full and after emptying it. The goal is to understand how bladder filling changes the uterine position, which could help make IUD insertion …

This study looked at whether special rocker sole shoes cause balance problems in people with type 2 diabetes and nerve damage in their feet. 25 adults completed the trial. Researchers measured how much people swayed while standing still in the special shoes.

This study looked at injuries from water sports that use foils (like hydrofoil boards) compared to those without. Researchers studied 65 adults who came to the emergency room after a boating accident. The goal was to understand how common foil-related injuries are and what types …

This study looked at how well young handball players can adjust their sense of balance (proprioception) during sudden movements. Researchers measured knee forces in 41 athletes aged 15-25 during jumps and side-step cuts. The goal was to understand if poor balance adjustment incre…

This study looked back at 170 adults with a serious eye infection called endophthalmitis to see if early surgery (within 48 hours) helps vision more than starting with medicine alone. Researchers compared how well people could see one month after treatment. The goal is to find ou…

This study looked at 116 kidney transplant patients to understand how certain immune cells (B cells) contribute to organ rejection. Researchers analyzed blood samples to find patterns that might predict rejection before it happens. The goal is to improve future treatments, not to…

This study looked at how the blood thinner rivaroxaban acts in people with severe obesity and in those who had weight-loss surgery (gastric bypass or sleeve gastrectomy) at least a year earlier. Sixty-seven participants took rivaroxaban for eight days, and researchers measured dr…

This study looked at 750 people hospitalized for a COPD flare-up to find out how many also had a pulmonary embolism (a blood clot in the lung). Doctors used a standard set of tests, including a blood test and special scans, to check for clots. Participants were followed for 3 mon…