University Hospital, Brest

This study tests whether a shared decision-making process, which uses personalized risk scores, can help patients with unprovoked blood clots choose the best duration of blood-thinning medication. The goal is to reduce the chance of another clot or serious bleeding while improvin…

This study tests whether a robot called LUNA-EMG can help people who had a stroke more than a year ago improve arm movement. Five participants will use the robot for 30 minutes per session alongside usual therapy. The goal is to see if robot-assisted exercises can make arm moveme…

This phase 3 trial is testing whether direct oral anticoagulants (DOACs) like apixaban or rivaroxaban are better than low-dose aspirin at preventing blood clots in people with JAK2V617F-positive myeloproliferative neoplasms (blood cancers). The study plans to enroll 1308 high-ris…

This study tests whether a minimally invasive glue procedure (embolization) can prevent chronic subdural hematoma from coming back. About 550 adults with a brain bleed will receive standard care plus this glue treatment or standard care alone. The goal is to see if the glue reduc…

This study tests whether giving botulinum toxin (Botox) injections early can prevent shoulder bone deformities in babies with obstetrical brachial plexus palsy, a nerve injury at birth. About 62 babies aged 10-11 months will receive either the injection or a sham procedure. The g…

This study tests whether adding baricitinib (a JAK inhibitor pill) to standard steroid treatment helps people with polymyalgia rheumatica (PMR) achieve disease control without needing long-term steroids. About 140 adults aged 50+ with active PMR will receive baricitinib (2 mg or …

This study tests whether a nurse-led prevention program can reduce the burden of side effects in people starting long-term corticosteroid therapy. About 191 adults will either receive the nurse program or standard care. The goal is to see if the program lowers complications like …

This study is for people with knee osteoarthritis who are considering knee replacement surgery. It compares a complete medical treatment plan to surgery to see if the medical approach can work just as well for pain and function. The goal is to help patients avoid or delay major s…

This study tests a new way to take pictures of active blood clots using a special PET scan. Researchers will use a radioactive tracer that sticks to fresh clots in blood samples from healthy volunteers. The goal is to see if this method can find clots more accurately than current…

This study is testing a new type of PET/CT scan that uses a special tracer to see if it can better detect and monitor chronic inflammatory and fibrotic diseases like rheumatoid arthritis, liver fibrosis, and lupus. About 390 adults with these conditions will get the scan to measu…

This study is testing a new type of PET scan to see if it can tell the difference between cancer that is still there and swelling caused by radiation treatment in people with head and neck cancer. About 180 adults who finished radiation therapy will get this special scan 3 months…

This study tests whether using a special dye (indocyanine green) during total thyroidectomy helps surgeons see and protect the parathyroid glands, reducing the risk of permanent hypoparathyroidism. About 242 adults scheduled for total thyroid removal will be randomly assigned to …

This study looks at whether giving blood thinners (LMWH) for 6 weeks after childbirth can prevent dangerous blood clots in women who have a moderate risk. About 2,400 women will be randomly assigned to receive either the blood thinner or standard care without it. The goal is to s…

This study tests a program called PREVENTURE for teenagers aged 14 to 17 who are at risk for alcohol and drug addiction. Participants are randomly assigned to either the program plus usual care or usual care alone. The goal is to see if the program reduces binge drinking and othe…

This study tests whether naloxegol, a drug that blocks opioid side effects in the gut without affecting pain relief in the brain, can prevent constipation and pneumonia in brain-injured patients in the ICU. About 370 adults with traumatic brain injury or bleeding around the brain…

This study tests whether a respiratory rehabilitation program—including exercise training, breathing exercises, and education—can improve quality of life for people with advanced non-small cell lung cancer who are on maintenance chemotherapy and immunotherapy. Researchers will co…

This study tests whether wearing Boarding Ring glasses can help people with vestibular neuritis (a sudden, severe vertigo attack) recover their balance more quickly. Researchers will measure changes in balance and eye movements over one week in 51 adult patients. The glasses are …

This study tests whether a 3-month pulmonary rehabilitation program (20 sessions of exercise and education) can improve quality of life and reduce breathlessness in people who have had a pulmonary embolism. Researchers will enroll 112 adults who still have symptoms at least 3 mon…

This study looks at whether a special parenting program can lower stress for parents who have alcohol use disorder and have children aged 4 to 12. About 90 parents will take part, and researchers will measure stress levels before and after the program. The goal is to see if the p…

This study tests whether personalized support from a sports and health professional after cardiac rehabilitation helps people with heart failure stay physically active for a full year. About 90 adults with stable heart failure will either receive this tailored follow-up or standa…

This study tests whether a capsaicin 8% patch (made from chili pepper extract) can reduce chronic nerve pain in teenagers aged 12 to 17 who have had pain for over 3 months after surgery or an injury. Half of the 46 participants will get the real patch, and the other half will get…

This study tests whether a nose spray made from treated seawater can shorten the time babies (1 month to 1 year) have symptoms of bronchiolitis, compared to a standard saltwater spray. About 458 infants with their first, mild-to-moderate bout of bronchiolitis will take part. Pare…

This study tests a mobile team of pain specialists who visit children and young adults (up to age 25) with moderate to severe intellectual disabilities, autism, or multiple disabilities. The team works with families and caregivers to assess and manage pain in the patient's usual …

This study looks at a condition called alloknesia, where light touch—like from clothing or a breeze—triggers itching. It focuses on people with atopic dermatitis (eczema), a common cause of chronic itching. Researchers will survey 160 adults to find out how often this happens and…

This study looks at why some women have a sensitive scalp—a condition that causes tingling, burning, or itching without any visible skin disease. Researchers will take small scalp biopsies from 40 women (20 with sensitive scalp and 20 without) to compare gene activity and skin st…

This study tracks 217 people after their first psychotic episode to see if language patterns and blood inflammation markers can predict whether they will develop bipolar disorder or schizophrenia. Participants give a recorded interview and blood sample at the start, then are foll…

This study aims to find early signs that predict quality of life more than four years after a minor ischemic stroke. Researchers will analyze data from 1,000 patients, including MRI scans, saliva samples, and questionnaires. The goal is to build a model that helps doctors underst…

This study looks at whether inflammation after a minimally invasive heart valve replacement (TAVI) can cause dangerous heart rhythm problems. Researchers will use a special PET scan to measure inflammation in the heart's electrical pathways. The goal is to better predict which pa…

This study looks at whether a detailed lung scan can predict if a blood clot will return in people who have had a pulmonary embolism (a clot in the lung). About 665 adults who have finished 3-6 months of blood thinners will get a special 3D scan. Researchers will follow them for …

This study looks at how preterm and full-term babies learn to tune out noises and lights (called habituation). Researchers will compare 70 infants to understand brain development and sleep quality. The goal is to find early signs of neurological problems so that babies can get he…

This study looks at different types of B cells (a kind of immune cell) in the blood and gums of people with gum disease. Researchers want to see if certain B cells are linked to more severe disease and how they change after surgery. The goal is to improve diagnosis, predict disea…

This study follows 150 adults with active cancer who have had a blood clot (venous thromboembolism) within the past two years. Researchers aim to learn more about how often clots return and how often serious bleeding occurs. No new treatments are tested; the goal is to gather inf…

This study follows 3,400 people who have had a blood clot (venous thromboembolism) to see how often clots return and what raises the risk. It focuses on two groups: patients under 50, and cancer patients of any age. Researchers will track recurrences over 1 to 5 years and also mo…

This observational study aims to understand how the CFTR gene is regulated in epididymal cells, which may help explain male infertility linked to cystic fibrosis. Researchers will collect leftover tissue samples from 20 men already scheduled for surgery. No extra procedures are n…

This study looks at whether emotional intelligence—the ability to understand and manage emotions—can help people with chronic orofacial pain (pain in the jaw and face lasting over three months). Researchers will compare 88 adults with and without this pain to see if emotional ski…

This study looks at whether ultrasound scans of the temporal and axillary arteries can help predict relapses in people with giant cell arteritis, a disease that causes inflamed blood vessels. Researchers will follow 100 patients to see if certain ultrasound findings are linked to…

This study looks at 32 people who still have shortness of breath or reduced quality of life after a pulmonary embolism (a blood clot in the lungs). They will receive a special PET/CT scan before and after a pulmonary rehabilitation program to see how the treatment improves lung f…

This study looks at how subtle changes in speech might help predict if someone is at risk for developing schizophrenia. Researchers will use computer tools to analyze speech patterns in 215 young people aged 15-30 who have had suicidal thoughts or behaviors. The goal is to find e…

This study aims to better understand rare forms of inflammatory arthritis, including those linked to other autoimmune diseases or cancer immunotherapy. Researchers will analyze joint tissue samples from 100 adults to compare the immune cells and molecules involved. The goal is to…

This study aims to find genetic differences that may explain why some women have repeated miscarriages or unexplained fetal deaths. Researchers will analyze DNA from 200 couples who have experienced these losses and compare it to DNA from couples without such history. The goal is…

This study tests a French version of a questionnaire that measures the burden on people caring for a loved one with COPD. Researchers will ask 224 caregivers to fill out the questionnaire and compare it with other standard surveys. The goal is to provide a reliable tool to identi…

This study is looking at whether certain markers in the blood can help predict side effects from a type of cancer treatment called immune checkpoint inhibitors. Researchers will collect blood samples and health data from 200 cancer patients during their regular check-ups. The goa…

This study tests whether patients can wear a virtual reality (VR) headset during awake brain surgery to help them stay calm and complete thinking and language tests. First, the VR headset was tested on people having orthopedic surgery under local anesthesia to make sure it is saf…

This study looks at whether training paramedics with simulations can make brain tumor patients more satisfied with their care. About 250 adults with a newly discovered brain tumor will fill out a questionnaire after their hospital stay. The goal is to see if this training helps p…

This study looks at existing medical images to measure the muscles that move the eyes, the optic nerve, and the fat inside the eye socket. Researchers want to see how reliable these measurements are when different doctors look at the same images. The goal is to improve knowledge …

This study looks at 50 people with chronic low back pain to see if simple movement tests used by physical therapists match what a high-speed camera captures. Participants perform six common tests while being filmed. The goal is to improve how we classify and treat different types…

This study is testing a secure app called Deneo Kid to see if it helps families and doctors better coordinate rehabilitation care for children and young people with neuromotor disabilities (like cerebral palsy or brain injury). About 20 children, their families, and their care te…

This study is not testing a new drug or treatment. Instead, researchers are combining health information from 20,000 people across 14 European groups who have had blood clots (venous thromboembolism). By merging this data, they hope to better understand who is at risk for future …

This study looks at whether people aged 15 to 25 who are at risk for psychosis have trouble recognizing themselves and telling themselves apart from others. Researchers will compare them to healthy volunteers using a special mirror-and-window test. No treatment or medication is i…