Can newer blood thinners beat aspirin for clot prevention in blood cancer patients?
NCT ID NCT05198960
First seen Mar 25, 2026 · Last updated Jun 22, 2026 · Updated 14 times
Summary
This phase 3 trial is testing whether direct oral anticoagulants (DOACs) like apixaban or rivaroxaban are better than low-dose aspirin at preventing blood clots in people with JAK2V617F-positive myeloproliferative neoplasms (blood cancers). The study plans to enroll 1308 high-risk patients. The goal is to see if these newer blood thinners reduce the risk of dangerous clots without causing too much bleeding.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
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Locations
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CH Bretagne Atlantique Vannes
RECRUITINGVannes, 56017, France
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CH Le Mans
NOT_YET_RECRUITINGLe Mans, 72000, France
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CH Libourne
NOT_YET_RECRUITINGLibourne, 33500, France
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CH Paul-Brousse (APHP)
NOT_YET_RECRUITINGVillejuif, 94800, France
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CH d'Annecy
NOT_YET_RECRUITINGAnnecy, 74374, France
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CH d'Argenteuil
NOT_YET_RECRUITINGArgenteuil, 95100, France
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CH d'Avignon
RECRUITINGAvignon, 84000, France
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CH de Béziers
NOT_YET_RECRUITINGBéziers, 34500, France
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CH de Morlaix
RECRUITINGMorlaix, 29600, France
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CH de Perpignan
NOT_YET_RECRUITINGPerpignan, 66000, France
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CH de Périgueux
RECRUITINGPérigueux, 24019, France
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CH de Rochefort
NOT_YET_RECRUITINGRochefort, 17300, France
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CH de Roubaix
RECRUITINGRoubaix, 59100, France
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CH de Versailles
NOT_YET_RECRUITINGVersailles, 78150, France
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CH de la Côte Basque Bayonne
NOT_YET_RECRUITINGBayonne, 64100, France
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CHD Vendée La Roche Sur Yon
RECRUITINGLa Roche-sur-Yon, 85925, France
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CHIC de Quimper
RECRUITINGQuimper, 29107, France
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CHR d'Orléans
RECRUITINGOrléans, 45100, France
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CHU Bordeaux
RECRUITINGBordeaux, 33604, France
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CHU Brest
RECRUITINGBrest, 29609, France
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CHU Grenoble Alpes
RECRUITINGGrenoble, 38043, France
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CHU La Réunion - Site Nord Félix GUYON
NOT_YET_RECRUITINGSaint-Denis, 97405, France
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CHU La Réunion - Site Sud
NOT_YET_RECRUITINGSaint-Pierre, 97410, France
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CHU Le Havre
NOT_YET_RECRUITINGLe Havre, 76083, France
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CHU d'Angers
RECRUITINGAngers, 49933, France
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CHU de Clermont-Ferrand
NOT_YET_RECRUITINGClermont-Ferrand, 63003, France
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CHU de Limoges - Hôpital Dupuytren
RECRUITINGLimoges, France
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CHU de Montpellier
NOT_YET_RECRUITINGMontpellier, 34295, France
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CHU de Nancy
RECRUITINGNancy, 54511, France
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CHU de Nantes - Hôtel-Dieu
NOT_YET_RECRUITINGNantes, 44093, France
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CHU de Rennes
NOT_YET_RECRUITINGRennes, 35033, France
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CHU de Tours
RECRUITINGTours, 37044, France
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Centre Henri Becquerel de Rouen
RECRUITINGRouen, 76038, France
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Centre Léon Bérard Lyon
NOT_YET_RECRUITINGLyon, 69000, France
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Clinique Sainte Anne Strasbourg
NOT_YET_RECRUITINGStrasbourg, 92210, France
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Hôpital Cochin (APHP)
NOT_YET_RECRUITINGParis, 75679, France
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Hôpital Henri Mondor (APHP)
RECRUITINGCréteil, 94010, France
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Hôpital Privé du Confluent Nantes
NOT_YET_RECRUITINGNantes, 44202, France
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Hôpital St-Louis (APHP)
RECRUITINGParis, 75010, France
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Hôpital privé Cesson-Sévigné
NOT_YET_RECRUITINGCesson-Sévigné, 35510, France
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Institut de Cancérologie Lucien Neuwirth St-Priest-en-Jarez
RECRUITINGSaint-Priest-en-Jarez, 42271, France
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Médipôle Hôpital Mutualiste Villeurbanne
RECRUITINGVilleurbanne, 69616, France
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What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Apixaban or Rivaroxaban (blood thinners)
What this could lead to
If successful, this could offer a more effective way to prevent dangerous blood clots in people with certain blood cancers, potentially reducing strokes and heart attacks.
What could go wrong
This is a large phase 3 trial, but blood thinners carry a risk of serious bleeding. It is unclear if the benefits will outweigh this risk in this specific patient group.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.