University Hospital, Brest

This phase 3 study tests whether adding chemotherapy to the immunotherapy drug pembrolizumab works better than pembrolizumab alone for people with advanced non-small-cell lung cancer that has high levels of a protein called PDL1. About 349 adults with stage IV or inoperable stage…

This study compares two ways to sedate ICU patients who need a breathing machine: inhaled sedation (using isoflurane gas) versus standard intravenous (IV) sedation. The goal is to see if the inhaled approach reduces the chance of delirium—a state of confusion that often occurs in…

This study aimed to see if injecting a person's own fat (lipofilling) could reduce pain and discomfort after a fingertip amputation. It planned to enroll adults with persistent nerve pain in the fingertip for 6 to 24 months after injury. However, the study was withdrawn before an…

This study was designed to test whether a French version of the Brief Fatigue Inventory (BFI) questionnaire works well for measuring fatigue in patients. It planned to enroll people whose main symptom was fatigue. However, the study was withdrawn before any participants were recr…

This study follows 70 infants with cystic fibrosis to see if a specific germ (Porphyromonas catoniae) found in their body at 12 months old can predict whether they will get a serious lung infection with Pseudomonas aeruginosa by age 3. Researchers collect sputum, stool, and blood…

This study looks at the stroma—the supportive tissue around tumors—in both benign and malignant growths. Researchers will examine 7,000 patient samples collected since 2000 at Brest University Hospital. The goal is to count non-tumor cells and measure matrix percentages in tumor …

This study reviews medical records of 20 adults who had a limb amputated to treat severe, treatment-resistant complex regional pain syndrome (CRPS). Researchers want to measure how long it takes from amputation to getting a functional prosthetic. The goal is to improve knowledge …

This study aims to create a French version of a questionnaire that measures distress related to sexual problems in women. Researchers will translate the original English survey and test it with 60 adult women in France to make sure it is easy to understand and accurate. The goal …

This study reviews medical records of about 30 adults who had surgery for a broken collarbone that didn't heal properly (nonunion). The goal is to see how often the bone heals after surgery and how patients recover. No new treatments or visits are involved—only existing data is u…