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Could a week of breathing support before lung surgery cut risks in half?

NCT ID NCT01685580

Disease control Sponsor: University Hospital, Brest Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether using a non-invasive ventilation machine for at least 7 days before lung cancer surgery could reduce lung and heart complications. The trial included 300 patients with lung cancer who also had breathing problems, obesity, or heart failure. The goal was to see if this approach could halve the rate of serious postoperative issues.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
non-invasive ventilation device (VPAP ST)
What this could lead to
If it works, this could make lung cancer surgery safer for patients with breathing or heart problems by reducing serious complications.
What could go wrong
This is a completed trial, but results may not apply to all patients. The technique is not a treatment for cancer itself, only a way to lower surgical risks.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

300 people

The number who actually took part.

Started

Oct 2012

Finished

Oct 2017

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patient over 18 years, to benefit from surgery scheduled for lung resection (lobectomy or segmentectomy) for primary lung cancer and having signed an informed consent. AND * Trouble obstructive (FEV / FVC \<70% and FEV \<80% predicted) Or restrictive (FVC \<80% or TLC \<80%) Or decrease in the ratio TLCO / VA \<60% Or history of respiratory failure with hypercapnic Pa CO2\> 45 mmHg in the year preceding surgery Or long-term oxygen Or heart failure (clinical signs of heart failure and LVEF \<55% or disorder of relaxation on echocardiography or atrial fibrillation) Or history of acute cardiogenic pulmonary edema. Or obesity (BMI\> 30 kg/m2) Exclusion Criteria: * Inability to consent * Patient declared inoperable given the comorbidities or refusing surgery or with unresectable tumors. * Patient operable but with no comorbidities described in the inclusion criteria * Contraindications to the non-invasive ventilation: * Lack of understanding of the technical * facial malformation * Tight stenosis of the upper airway * uncontrollable vomiting * Unable to remove the mask * Cognitive impairment or severe psychiatric jeopardizing the observance of the NAV * Patient non-insured * Patient already on invasive ventilation or non-invasive * During Pregnancy

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Conditions

The condition(s) this trial relates to.

lung cancer non-small cell lung carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Surgery for primary lung cancer

Contacts and locations

Locations

  • CHI Créteil

    Créteil, 94010, France

  • CHRU de Brest - Hôpital Morvan

    Brest, 29609, France

  • CHU Angers

    Angers, 49933, France

  • CHU Limoges

    Limoges, 87042, France

  • CHU Saint-Etienne

    Saint-Etienne, 42055, France

  • CHU de Rouen

    Rouen, France, 76031, France

  • Centre Hospitalier Victor Dupouy

    Argenteuil, France, 95100, France

  • Centre Hospitalier du Pays d'Aix

    Aix-en-Provence, France, 13616, France

  • Clinqiue du Grand Large

    Brest, France, 29200, France

  • Hospital, Pasteur

    Nice, 06000, France

  • Hôpital Nord Ouest Villefranche Sur Saône

    Villefranche-sur-Saône, France, 69655, France

  • Hôpital Pontchaillou

    Rennes, France, 35033, France

  • Inter Army Hospital

    Clamart, 92141, France

  • Inter Army Hospital, Clermont-Tonnerre

    Brest, 29609, France

  • Inter Army Hospital, Saint-Anne

    Toulon, 83041, France

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Other studies related to the condition(s) this trial covers.