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Knee cartilage showdown: which surgery wins?

NCT ID NCT00560664

Disease control Sponsor: University Hospital, Brest Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study compared two surgical methods to repair damaged knee cartilage: a newer cell-based technique (autologous chondrocyte implantation) and a standard bone-graft method (mosaicoplasty). 58 adults aged 18-50 with isolated knee lesions took part. The goal was to see which approach provides better knee function and healing after 2 years.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 3

Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.

Participants

58 people

The number who actually took part.

Start date

Apr 2007

Finished

Aug 2013

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 50 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * isolated femoral osteochondral lesion * aged 18 to 50 * grade 3 or 4 lesion (ICRS) sized 2,5 cm2 to 7,5 cm2. * IKDC score below 55 Exclusion Criteria: * pregnancy * allergy * arthrosis * varus or valgus angle greater than 10° * ACL laxity * Severe chronic disease * BMI \> 30 Kg/m2 * HIV, B or C Hepatitis

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Conditions

The condition(s) this trial relates to.

osteochondritis dissecans

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Knee chondral or osteochondral defect

Contacts and locations

Locations

  • CH Nord Mayenne

    Mayenne, 53 103, France

  • CHU de Caen

    Caen, 14 033, France

  • CHU de Grenoble

    Grenoble, 38 042, France

  • CHU de Lyon

    Lyon, Lyon, 69300, France

  • CHU de Nancy

    Nancy, 54 035, France

  • CHU de Strasbourg

    Strasbourg, 67 400, France

  • Centre médico chirurgical de Dracy-Le-Fort

    Dracy-le-Fort, 71 640, France

  • Ch Versailles

    Le Chesnay, 78 150, France

  • Clinique Chenieux

    Limoges, 87 000, France

  • Clinique du cours Dillon

    Toulouse, France

  • HIA Bégin

    Saint-Mandé, 94 160, France

  • Orthopaedic surgery Departement Brest University Hospital

    Brest, 29200, France