Could a simple inhaler ease dental pain in the ER?
NCT ID NCT06495372
First seen Jun 13, 2026 · Last updated Jun 20, 2026 · Updated 1 time
Summary
This study tested whether methoxyflurane (Penthrox®), a pain-relief inhaler already used for trauma, can quickly reduce moderate to severe dental pain in adults. 190 participants received either methoxyflurane or a placebo alongside standard care. The goal was to see if pain dropped significantly within 15 minutes, offering a fast solution for busy emergency rooms.
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
-
CHU Brest
Brest, 29200, France
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
methoxyflurane (Penthrox®)
What this could lead to
If it works, this could provide a fast, effective pain relief option for people with dental emergencies, especially when dentists are scarce.
What could go wrong
This is a completed Phase 3 trial, but results are not yet published. Methoxyflurane is already approved for trauma pain, so its use in dental pain may not offer a major advantage over existing options.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.