Ohsu Knight Cancer Institute

This study tests whether combining three drugs (axatilimab, retifanlimab, and paclitaxel) is safe and works against advanced or metastatic solid tumors. About 38 adults with tumors that have spread or come back will receive the combination. The goal is to find the best dose and s…

This study tests a new combination of drugs for people newly diagnosed with a specific type of acute myeloid leukemia (AML). The treatment uses venetoclax, a targeted drug, along with chemotherapy drugs cladribine, cytarabine, and azacitidine. The goal is to see if this combinati…

This study tests a combination of two drugs—glofitamab and ibrutinib—plus a pretreatment drug called obinutuzumab for people with mantle cell lymphoma (MCL). It includes patients aged 65 and older, or those 18-64 with high-risk features. The goal is to see if the combo is safe an…

This early-phase study tests a drug called pemigatinib, which blocks a protein that helps leukemia cells grow. It is given after standard chemotherapy to adults newly diagnosed with acute myeloid leukemia (AML). The goal is to find the safest dose and see if it improves remission…

This study tests whether adding venetoclax to a standard chemotherapy regimen (FLAG IDA) helps more people with newly diagnosed acute myeloid leukemia (AML) achieve deep remission. About 102 adults aged 18 to 65 will be randomly assigned to the new combo or standard treatment. Th…

This study offers a bone marrow transplant using stem cells that are specially selected to remove certain immune cells. The goal is to lower the risk of the donor cells attacking the patient's body, a serious side effect called graft-versus-host disease. It is for people with can…

This study tests whether removing less healthy tissue around a melanoma (narrow excision) works as well as the standard wider removal. About 1,000 adults with early-stage melanoma will be randomly assigned to one of the two surgeries. The goal is to see if the narrower approach r…

This early-stage trial tests the safety and effectiveness of combining three drugs (tafasitamab, acalabrutinib, and obinutuzumab) in people with previously untreated chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL). The study involves 27 adults who will rece…

This study tests whether adding the immunotherapy drug mosunetuzumab to standard chemotherapy is safe and effective for people with a fast-growing type of lymphoma that has a specific genetic change (c-Myc rearrangement). About 30 adults aged 18-75 who have not yet been treated w…

This study tests whether using two different contrast agents (gadolinium and ferumoxytol) during an MRI can provide clearer images of brain abnormalities, such as tumors or nerve disorders. About 150 participants with neurological symptoms or brain findings will undergo MRI scans…

This study tests whether taking a daily fiber supplement can change the types and amounts of bacteria living in the colon. The gut microbiome plays a key role in health, and certain bacteria are linked to colon polyps that can turn into cancer. Researchers will measure changes in…

This study tests whether giving a combination of chemotherapy drugs (cytarabine, methotrexate, and hydrocortisone) into the spinal fluid can prevent severe brain-related side effects in people receiving CAR T-cell therapy for blood cancers. About 20-70% of CAR T-cell patients exp…

This study tests whether the heart medication amiodarone can prevent atrial fibrillation (an irregular, often rapid heartbeat) in people recovering from minimally invasive esophageal cancer surgery. Atrial fibrillation is the most common complication after this surgery, and there…

This study tests whether olanzapine, a drug that affects brain chemicals, can help people with advanced cancer who are losing weight and appetite. About 66 adults with certain cancers (like lung, stomach, or colon) will receive either olanzapine or a placebo. The goal is to see i…

This study is testing whether getting immunotherapy in the morning or the afternoon makes it work better for people with advanced or metastatic solid tumors like lung, kidney, or skin cancer. Researchers think the body's internal clock might affect how the immune system responds.…

This study tests an internet-based program (iLIVE) that combines weight loss and resistance training to help men who have had prostate cancer and hormone therapy. The goal is to reduce obesity and frailty, which can improve quality of life and lower fall risk. About 250 participa…

This study looks at whether creative arts like drawing, painting, and sculpting can help children with cancer feel better and improve their quality of life. Researchers will compare art activities to watching videos in 72 children aged 8 to 13 who were diagnosed with cancer in th…

This study tests whether adding social support to group exercise helps older men (65+) with prostate cancer feel less lonely and improve their mental and physical health. 150 men will be assigned to one of three 6-month programs: socially-enhanced group exercise, standard group e…

This study looks at how hormone therapy changes PSMA levels in men with prostate cancer. Researchers want to find the best time to do a PSMA PET scan after starting treatment. About 80 men with either castration-sensitive or castration-resistant prostate cancer will take part. Th…

This study offers free genetic testing to the general public to find people with inherited cancer syndromes like hereditary breast and ovarian cancer or Lynch syndrome. Researchers want to see if broad testing is better than only testing those with a family history. Up to 27,500 …

This study compares a new MRI technique (aMRI) to standard PET scans for measuring brain tumor activity in 20 adults with glioma. The goal is to see if aMRI can provide similar information without using radiation. If successful, this could make metabolic imaging more accessible a…

This study is for people with pancreatic cancer that can be removed by surgery or has spread. Researchers want to see how different drugs change tumor biology by comparing biopsies taken before and after treatment. The goal is not to cure the disease now, but to learn which drugs…

This study looks at whether men and women have different symptoms while receiving immunotherapy for cancer. Researchers will track patient-reported symptoms and quality of life, as well as clinician assessments. The goal is to better understand how sex and gender affect treatment…

This study looks at whether CAR-T cell therapy, a treatment for certain blood cancers, reduces the protection that past vaccines (like measles or tetanus shots) provide. Researchers will test the blood of 45 adults with multiple myeloma or non-Hodgkin lymphoma before and after CA…

This early phase 1 trial is studying how the drug OMO-103 affects pancreatic cancer cells in 12 patients with advanced or metastatic disease. The main goal is to see if the drug causes measurable changes in the tumor's biology by comparing tissue samples taken before and after tr…

This study looks at whether a simple blood test can help doctors decide if rectal cancer patients can avoid surgery and keep their rectum. Researchers will measure tiny bits of tumor DNA in the blood (ctDNA) before, during, and after standard treatment in 50 adults with stage II …