Ohsu Knight Cancer Institute

This study tests whether switching from one chemotherapy combination to another before surgery can help people with pancreatic cancer. It includes patients whose tumors can be removed or are borderline removable. The goal is to see if the switch leads to better surgical outcomes …

This early-phase trial tests the safety and best dose of the chemotherapy drug eribulin when given with radiation before surgery for a rare cancer called retroperitoneal liposarcoma. About 15 adults with this abdominal fat-cell tumor will receive the combination to see how well i…

This early-stage study tests the safety of combining the chemotherapy drug TAS-102 with radiation therapy for people with stage II or III rectal cancer that hasn't been treated yet. The goal is to find the safest dose of TAS-102 to use with radiation before surgery. About 19 adul…

This study was designed to test whether adding the immunotherapy drug pembrolizumab to standard hormone therapy and radiation could improve outcomes for men with high-risk prostate cancer that hasn't spread. The goal was to see if the combination could eliminate cancer cells more…

This study tests whether adding the immunotherapy drug pembrolizumab can help men whose advanced prostate cancer has stopped responding to the hormone therapy enzalutamide. About 58 men with castration-resistant prostate cancer that has spread will receive pembrolizumab while con…

This early-stage trial tests a combination of the oral drug venetoclax with standard chemotherapy and targeted therapies in adults with a specific, hard-to-treat leukemia (Ph+ ALL) that is either newly diagnosed or has returned. The main goal is to find the safest dose and see ho…

This study tests a combination of two drugs—cabazitaxel (a chemotherapy) and enzalutamide (a hormone blocker)—in men with prostate cancer that has spread and stopped responding to standard hormone therapy. The goal is to find the safest dose and see if the combo can lower PSA lev…

This early-phase study tests a combination of two drugs—calaspargase pegol-mknl and cobimetinib—in people with advanced pancreatic cancer that has spread. The goal is to find the safest dose and see if the combo can control the disease by cutting off the cancer cells' food supply…

This study tests a combination of three drugs (apalutamide, abiraterone, and prednisone) given after chemotherapy for men with advanced prostate cancer that has spread and hasn't been treated before. The goal is to see if this approach can lower PSA levels more effectively and al…

This study tests a combination of three drugs (isatuximab, carfilzomib, and pomalidomide) in people with multiple myeloma that has come back or no longer responds to treatment. The goal is to see if this mix can shrink or control the cancer. The trial enrolled 5 adults and is no …

This study looks at whether a new electronic referral system, combined with extra training for clinic staff, can help more people who smoke get support to quit. Over 9,000 patients from community health centers in Oregon are taking part. The goal is to see if this approach increa…

This early-stage trial tests a combination of two drugs—entrectinib and ASTX727—in adults with acute myeloid leukemia (AML) that has returned or not responded to treatment and has a specific genetic change (TP53 mutation). The goal is to find the safest dose and see if the combin…

This study looks at whether a special PET scan called Axumin can find prostate cancer that has returned after treatment, in patients whose usual PSMA PET scan was negative. About 50 adults with rising PSA levels will get an Axumin scan. The goal is to see if this scan spots the c…

This study looks at whether a simple, swallowable device can help screen for esophageal cancer in rural areas without needing a traditional endoscopy. About 110 people with chronic heartburn and other risk factors will try the device at their local clinic. The goal is to see if p…

This study tests whether a new device called OmnEcoil can safely and effectively combine two prostate cancer tests—MRI and biopsy—into a single session. Currently, these are done separately, which means extra visits and procedures. The trial involves 45 men aged 45 and older with…

This phase 2 trial tests whether atorvastatin, a widely used cholesterol medication, can prevent melanoma from returning or spreading in people who have had high-risk melanoma surgically removed. About 150 adults with stage IIA, IIB, or IIIA melanoma will receive either atorvasta…

This early study tests whether a drug called glucarpidase can lower the toxic side effects of high-dose methotrexate in adults with osteosarcoma (a type of bone cancer). About 12 participants will receive glucarpidase alongside their chemotherapy to see if it helps clear the chem…

This study looks at whether adding a simple picture guide to standard counseling can help lower anxiety and depression in women with early-stage breast cancer who are about to start radiation therapy. About 62 women will take part, and their stress levels will be tracked using qu…

This study looks at whether a simple online questionnaire called MammoScreen can help identify women who need extra breast cancer screening. About 1,100 women aged 40 to 74 will use the tool through their patient portal. The goal is to see if it increases appropriate screening an…

This study looks at whether a health education campaign can help people in Oregon find melanoma (a serious skin cancer) earlier. Researchers will compare awareness and cancer data from Oregon (where the campaign runs) with data from Washington and Utah (where it does not). Up to …

This study tests a decision aid designed for people with non-small cell lung cancer. The tool helps patients and doctors talk together about treatment options, risks, and what matters most to the patient. About 98 adults with lung cancer will use the tool to see if it improves th…

This study aims to uncover the genetic causes of blood and bone marrow cancers by analyzing samples from 5,000 participants. Researchers will look for specific cell abnormalities that drive cancer growth and test whether existing drugs can reverse them. The goal is to develop gen…

This study aimed to see if a special MRI scan, using extra oxygen, could create maps of low-oxygen areas in brain tumors. Low oxygen makes tumors harder to treat. The study was withdrawn before enrolling anyone, so no results are available. It was designed for adults with known o…