Ohsu Knight Cancer Institute

This is an early safety study testing a new combination of two drugs for people with advanced pancreatic cancer that has spread. The main goal is to find the safest and most effective dose by giving the drugs to 15 patients and carefully monitoring them. Researchers hope the two …

This study is testing a flexible treatment plan for people with pancreatic cancer that might be removable by surgery. Doctors will give one chemotherapy combination first, then switch to a different one if the cancer isn't responding well or if side effects are too severe. The go…

This study aimed to test a combination of three treatments for men with high-risk prostate cancer that has not spread. The approach combined a drug to boost the immune system (pembrolizumab) with standard hormone-blocking therapy and radiation. The goal was to see if this combina…

This study is testing whether a combination of three drugs—apalutamide, abiraterone acetate, and prednisone—can better control advanced prostate cancer that has spread to other parts of the body. The treatment is given to men who have already completed a standard chemotherapy. Th…

This early-stage study aims to find the safest dose of the chemotherapy drug TAS-102 when given alongside radiation therapy to patients with stage II or III rectal cancer. The goal is to shrink the tumor before the patient undergoes standard surgery and follow-up chemotherapy. Re…

This study is testing whether making it easier for doctors to electronically refer patients to state Quitline services helps more people get support to stop using tobacco. It involves over 9,000 patients across 20 community health centers in Oregon. Researchers are comparing two …

This early-stage study is testing whether two drugs—entrectinib and ASTX727—can be safely combined to treat acute myeloid leukemia (AML) that has returned or resisted treatment and has a specific genetic change (TP53 mutation). The trial involves about 13 adults and aims to find …

This early-stage study is testing the safety and best dose of a chemotherapy drug called eribulin when given with radiation therapy before surgery. It involves 15 patients with a rare abdominal cancer called retroperitoneal liposarcoma. The goal is to see if this combined approac…

This small, early-stage study is testing whether a drug called glucarpidase can help adults with osteosarcoma (a type of bone cancer) better tolerate their chemotherapy. The goal is to see if giving glucarpidase after high-dose methotrexate treatment reduces side effects and lead…

This study is testing a personalized treatment method for people with advanced breast, prostate, ovarian, pancreatic, or sarcoma cancers that have spread. Doctors analyze each patient's tumor using genetic and protein tests to understand how the cancer is changing and which drugs…

This study is testing if adding the immunotherapy drug pembrolizumab can help control advanced prostate cancer that has started growing again despite treatment with the standard drug enzalutamide. It involves about 58 men whose cancer has spread and is no longer responding to hor…

This study is testing the safety and effectiveness of combining two drugs, enzalutamide and cabazitaxel, for men with advanced prostate cancer that has spread and is no longer responding to standard hormone treatments. The goal is to see if using these drugs together can better c…

This study is testing a combination of three drugs—isatuximab, carfilzomib, and pomalidomide—for adults with multiple myeloma that has come back (relapsed) or stopped responding to treatment (refractory). The goal is to see if this combination can control the cancer and for how l…

This study is testing if a Fluciclovine PET scan can help find prostate cancer that has come back after initial treatment in men whose other scan (PSMA PET) was negative. It will enroll 50 men whose blood tests suggest the cancer has returned. The main goal is to see if this seco…

This study is testing a new medical device called the OmnEcoil system. It aims to combine an MRI scan and a prostate biopsy into a single procedure, which are normally done separately. The research will check if the device is safe, works properly, and is comfortable for patients …

This study is testing whether photos taken with smartphone apps and special imaging devices can help screen for melanoma skin cancer. Researchers are comparing these images to a standard dermatologist's exam to see if they are just as good at finding concerning moles early. About…

This study is testing a new, swallowable capsule that collects cells from the esophagus to screen for cancer and pre-cancerous conditions. It aims to see if this simple, non-invasive tool is practical and acceptable for use in rural primary care clinics, where access to tradition…

This study is testing whether atorvastatin, a medication commonly used to lower cholesterol, can prevent melanoma skin cancer from spreading to other parts of the body after it has been surgically removed. The trial involves 150 adults who have had high-risk melanoma surgically r…

This study is testing a digital questionnaire called MammoScreen that helps identify women at average or increased risk for breast cancer. It aims to see if integrating this tool into electronic health records helps more women get appropriate screening and genetic counseling refe…

This study is testing a simple conversation tool designed to help people with lung cancer better understand their treatment options and participate in decisions with their doctors. The tool is being evaluated at two cancer centers with 98 participants who have non-small cell lung…

This study is testing whether adding a photo guide to standard counseling helps reduce stress, anxiety, and depression in women receiving radiation therapy for early-stage breast cancer. Researchers are comparing two groups: one receives verbal counseling plus a picture book show…

This study aims to discover what causes blood and bone marrow cancers like leukemia. Researchers will analyze cancer cells from up to 5,000 participants to find the specific abnormalities that make the cells grow. The goal is to use this knowledge to develop more effective and le…

This study aimed to test if a special type of MRI scan, done while a patient breathes extra oxygen, could create a map showing which parts of a brain tumor have low oxygen. Low oxygen in tumors can make standard treatments like radiation less effective. The goal was to see if thi…