National Institute Of Mental Health (nimh)

This study tests whether playing virtual reality games can improve thinking skills like attention and memory in children aged 8 to 16 with ADHD. In the first part, all kids play the games; in the second part, some play the full version and others a limited version. The goal is to…

This study tests whether a drug called HNK can quickly improve symptoms in people with major depression that hasn't gotten better with standard treatments. About 50 adults aged 18 to 70 will receive four infusions of HNK and four of a placebo over several weeks, with their depres…

This study uses special PET scans to see if inflammation in the brain is higher in people with major depressive disorder (MDD) during a depressive episode compared to healthy volunteers. Researchers will scan about 64 adults aged 18-70, including those with MDD and healthy contro…

This study tests a new radioactive tracer called 11C-JMJ-129 that attaches to a protein called PDE4D in the body, which is linked to thinking and mood. Healthy volunteers aged 18 and older will have PET and MRI scans to see how well the tracer works. The goal is to improve future…

This study uses a special brain scan (MRS) to measure how the brain makes two important chemical messengers: glutamate and GABA. Researchers will scan healthy adults aged 18-65 to improve the accuracy and reliability of this imaging technique. The goal is to better understand nor…

This study follows healthy boys and girls from age 8 to 17 to see how hormones and brain changes happen together during puberty. Researchers use brain scans, hormone tests, and thinking tasks to map normal development. The goal is to understand why some mental health conditions l…

This study is looking at whether a special PET scan tracer can spot inflammation in the brains of people who have long-term symptoms after COVID-19 (called long COVID or Neuro-PASC). About 60 adults aged 18 to 70, including healthy volunteers, will get MRI and PET scans over seve…

This study screens up to 16,000 people aged 3 to 99 with mood or anxiety disorders, as well as healthy volunteers, to see if they can join other research studies at the National Institute of Mental Health. Participants undergo interviews, medical tests, and brain scans to collect…

This study tests a new imaging tracer to see if it can measure brain inflammation in people with Alzheimer's disease or mild cognitive impairment. About 90 volunteers aged 50 and older, including healthy individuals, will undergo PET and MRI scans. The goal is to understand how i…

This study aims to improve MRI and MRS scanning methods to better see and measure brain chemicals. It involves 300 healthy adults aged 18-65 who will have scans at the NIH. The goal is to make these imaging tools more accurate for future research on psychiatric illnesses.

This study aims to learn how sleep changes as children's brains grow, from infancy to early childhood. Researchers will monitor sleep patterns in healthy children and those with conditions like autism or ADHD. The goal is to create a database that helps understand normal and atyp…

This study aims to understand how a specific brain chemical (GABA) and brain connections relate to how adolescents with autism process sounds and language. Researchers will use brain scans and a safe, non-invasive magnetic stimulation technique on participants' scalps to measure …

This study looks at children and teens ages 7-17 who have severe mood problems, like constant anger, sadness, or irritability, along with intense tantrums. Researchers will use interviews, tests, and brain scans to learn more about these symptoms and how the brain works different…

This study aims to improve MRI scanning techniques to better understand how mood and anxiety disorders affect the brain. Researchers will scan the brains of healthy volunteers and people with major depressive disorder while they perform tasks or view images. The goal is to develo…

This study looks at how negative feelings like stress, pain, or hunger change the way people make decisions. Healthy adults aged 18 to 55 will experience short emotional stressors (like watching a sad video or putting a hand in ice water) and then perform computer tasks while the…

This study uses brain scans (fMRI) to see how blood flow changes in the brain when healthy adults perform tasks involving vision, recognition, and memory. Researchers aim to understand which brain areas are active during these tasks. About 4,100 healthy volunteers aged 18 to 65 w…

This study aims to understand what happens in the brain when someone thinks about or attempts suicide. Researchers will use brain scans, sleep tests, and blood work to compare four groups: people who recently had suicidal thoughts or attempts, those with past thoughts, people wit…

This study follows up with 1000 adults who previously took part in mood disorder research at the National Institute of Mental Health. Participants fill out online surveys and may have a phone interview about their current symptoms and treatments. The goal is to understand the lon…

This study aims to recruit 2,000 healthy adults aged 18-70 for future research at the National Institute of Mental Health. Volunteers complete online surveys, in-person interviews, physical exams, and optional brain scans. Their de-identified data will be shared with other scient…