New brain imaging tool could unlock secrets of depression and Alzheimer's
NCT ID NCT06874205
First seen Nov 01, 2025 · Last updated Jun 16, 2026 · Updated 33 times
Summary
This study tests a new radioactive tracer called 11C-JMJ-129 to see how well it can image a protein called PDE4D in the brain and body of healthy volunteers. PDE4D is linked to thinking and mood, and may play a role in disorders like Alzheimer's and depression. Researchers will also test if a medication called disulfiram can improve the quality of the brain images by preventing the tracer from breaking down too quickly. About 40 healthy adults aged 18 and older will take part.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contact
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Locations
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National Institutes of Health Clinical Center
RECRUITINGBethesda, Maryland, 20892, United States
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As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.