National Institute Of Mental Health (nimh)

This study tested whether combining a non-invasive brain stimulation technique called rTMS with cognitive therapy can help treat major depression. Researchers used MRI scans to personalize the brain target for each participant. 32 adults with depression took part in daily session…

This study looked at whether a drug called LY500307 can prevent mood symptoms in postmenopausal women who had depression during perimenopause and became depressed again after stopping estrogen therapy. 74 healthy women aged 45-65 took either the drug or a placebo for 3 weeks whil…

This study used PET scans to measure blood flow in the frontal lobe while participants performed thinking tasks. It included healthy volunteers and people with schizophrenia or Parkinson's disease. The goal was to understand how the frontal lobe works during cognitive activities …

This completed study looked at how the brains of people with schizophrenia work when they are not taking antipsychotic medication. The goal was to tell apart the effects of the illness itself from the effects of the drugs. 648 participants stayed in a hospital and underwent brain…

This study looked at how dopamine receptors in the brain work in people with schizophrenia compared to healthy volunteers. Researchers used special PET and MRI scans to measure two types of dopamine receptors. The goal was to better understand what causes schizophrenia, which cou…

This completed study from the National Institute of Mental Health surveyed over 3,600 English-speaking adults online every two weeks for six months. Researchers asked about stress, mental health symptoms, and how the pandemic changed daily life. The goal was to understand the rel…

This completed study from the National Institute of Mental Health looked at over 1,500 women to better understand the symptoms of premenstrual syndrome (PMS) and a severe form called PMDD. Researchers used interviews, rating scales, and hormone tests to track mood and behavior ch…

This study looked at how hormone changes during perimenopause (the time around menopause) might affect mood and behavior. Over 1,100 women participated, including those with depression symptoms and healthy volunteers. No treatments were given; instead, researchers used surveys an…

This study tested a set of questions to better identify suicide risk in young people aged 8–17 with autism or other neurodevelopmental disorders. Researchers asked 278 participants and their parents about thoughts of self-harm and understanding of death. The goal was to create a …

This study looked at 74 women with a history of postpartum depression to see if mood symptoms are caused by the sudden drop in hormones after childbirth or by long exposure to those hormones. Researchers created a hormone environment similar to pregnancy and then withdrew it. The…

This study looked at how cooling the brain changes its activity in healthy adults. Participants wore a cooling cap while researchers measured brain responses using transcranial magnetic stimulation (TMS). The goal was to better understand brain plasticity, not to treat any diseas…

This completed study from the National Institute of Mental Health looked at nearly 5,000 people with schizophrenia or related disorders, along with their siblings. The goal was to find genes linked to the illness and see how they affect brain function. This research helps scienti…

This study aimed to understand the brain and genetics behind autism spectrum disorders (ASD). Researchers compared brain scans, thinking tests, and DNA from 678 people with ASD, healthy volunteers, and their parents. The goal was to find links between brain activity, behavior, an…

This study used advanced brain imaging (MRI and MEG) to look for differences in brain structure, chemistry, and activity between people with schizophrenia and healthy volunteers. Over 3,200 adults took part. The goal was to better understand the brain changes linked to schizophre…

This study tested different ways to apply non-invasive brain stimulation (like magnetic pulses) in 83 healthy adults aged 18-65. The goal was to learn how to make these techniques more effective for diagnosing and treating brain disorders. Participants completed tasks, had brain …

This study used PET scans to look at dopamine and blood flow in the brains of 502 people, including healthy volunteers and those with Parkinson's disease or schizophrenia. The goal was to understand how these conditions affect brain function and to compare inherited versus non-in…

This study looked at nearly 2,000 people from the community to understand how depression, anxiety, and migraine are passed down through families. Researchers interviewed family members of all ages, including children as young as 8, to track patterns of these conditions over time.…

This study used brain imaging (fMRI) to see how children's brains react during emotional tasks and whether those reactions are linked to their temperament. Researchers studied children from infancy to age 60, focusing on how brain activity might relate to risk for mood and anxiet…

This study looked at how the COVID-19 pandemic affected the mental health of 193 Amish and Mennonite adults who already had depression, anxiety, or bipolar disorder. Participants filled out surveys about their symptoms and pandemic-related stress over two years. The goal was to u…