Methodist Health System
Clinical trials sponsored by Methodist Health System, explained in plain language.
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New group approach helps obesity patients shed pounds
Disease control CompletedThis study tested a new way to help adults with obesity lose weight using personalized health planning in group medical visits. Eleven motivated adults aged 30 to 60 with a BMI between 35 and 50 took part. The approach tracked weight, blood pressure, waist size, and mood changes …
Phase: NA • Sponsor: Methodist Health System • Aim: Disease control
Last updated May 26, 2026 06:55 UTC
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Vein fix for dialysis patients: new study shows how surgeons reopen blocked chest veins
Disease control CompletedThis study looked at 45 adults on hemodialysis who had a blocked or narrowed superior vena cava (SVC), a large vein in the chest. Doctors used surgery or a stent to reopen the vein and relieve symptoms. The goal was to see how well the repair worked over time and whether it helpe…
Sponsor: Methodist Health System • Aim: Disease control
Last updated May 26, 2026 06:52 UTC
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New hope for kidney transplant patients: delaying stronger drugs may speed recovery
Disease control CompletedThis study tested whether giving one dose of belatacept can safely delay the start of a stronger anti-rejection drug (tacrolimus) in kidney transplant patients whose new kidneys are slow to start working. 67 adults with delayed graft function took part. Researchers tracked how qu…
Sponsor: Methodist Health System • Aim: Disease control
Last updated May 26, 2026 06:45 UTC
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New stent shows promise for treating tricky brain aneurysms
Disease control CompletedThis study looked at how well a special stent (Enterprise 2) works with coils to treat wide-neck brain aneurysms. Ten adults with this condition were enrolled. The main goal was to see if the stent stays in place and doesn't cause problems like narrowing or shifting over time.
Sponsor: Methodist Health System • Aim: Disease control
Last updated May 26, 2026 06:43 UTC
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Liver transplant study tests Lower-Dose immune drugs to prevent deadly complication
Disease control CompletedThis study looked at whether giving liver transplant patients lower doses of immune-suppressing drugs could reduce the risk of graft-versus-host disease (GVHD), a serious complication where donor cells attack the recipient's body. The study involved 100 adults who received a live…
Sponsor: Methodist Health System • Aim: Disease control
Last updated May 22, 2026 14:04 UTC
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New stent system shows promise for Hard-to-Treat brain aneurysms
Disease control CompletedThis study tested a special stent system to help treat brain aneurysms with a wide neck. A wide-neck aneurysm is harder to seal because the opening is large. The stent acts like a bridge to hold tiny coils inside the aneurysm, blocking blood flow. The study included 30 adults wit…
Phase: NA • Sponsor: Methodist Health System • Aim: Disease control
Last updated May 22, 2026 13:55 UTC
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New stomach-shrinking procedure tested for weight loss
Disease control CompletedThis study looked at a procedure called endoscopic sleeve gastroplasty to help people with obesity lose weight. 75 adults who had trouble losing weight with diet and exercise alone took part. The procedure reduces stomach size using a tube inserted through the mouth, and particip…
Sponsor: Methodist Health System • Aim: Disease control
Last updated May 22, 2026 13:51 UTC
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Heart drug studied in 6,500 african americans: does it work as well?
Disease control CompletedThis study looked at whether the drug sacubitril/valsartan works as well in African American patients with heart failure as it does in others. Over 6,500 African American adults with reduced heart pumping function took part. Researchers measured how many died or were hospitalized…
Sponsor: Methodist Health System • Aim: Disease control
Last updated May 22, 2026 13:51 UTC
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Groundbreaking facial transplants give new hope to trauma survivors
Disease control CompletedThis study tested facial transplantation in 3 people with severe facial damage from accidents. The goal was to improve their quality of life and facial function. Participants received a donor face and were followed to see how well they recovered and adapted. Because lifelong anti…
Phase: NA • Sponsor: Methodist Health System • Aim: Disease control
Last updated May 20, 2026 11:54 UTC
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Simple dose of clotting drug may stop brain bleeds from blood thinners
Disease control CompletedThis study looked at whether a fixed dose of a clotting drug (4F-PCC) is safe and effective for people with brain bleeds caused by common blood thinners like rivaroxaban or apixaban. Researchers compared the fixed dose to the standard weight-based dose in 76 adults. The goal was …
Sponsor: Methodist Health System • Aim: Disease control
Last updated May 19, 2026 11:48 UTC
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ICU drug tapering study shows promise for safer care
Disease control CompletedThis study tested whether a pharmacist-led program could safely reduce the use of acid-suppressing drugs given to prevent stress ulcers in intensive care unit (ICU) patients. 120 adults in the ICU were included, and those without high-risk conditions had their stomach acid medica…
Sponsor: Methodist Health System • Aim: Disease control
Last updated May 18, 2026 12:11 UTC
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Poop pills? fecal transplant shows promise for gut infection
Disease control CompletedThis study tested a procedure called fecal microbiota transplant (FMT) in 24 adults with recurring Clostridium difficile (C. diff) infection. FMT involves placing healthy donor stool into the patient's colon to restore good bacteria killed by antibiotics. The goal was to see if F…
Phase: PHASE4 • Sponsor: Methodist Health System • Aim: Disease control
Last updated May 18, 2026 11:58 UTC
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New dosing strategy for liver cancer radiation shows promise
Disease control CompletedThis study looked at a flexible dosing method for delivering tiny radioactive beads (Y90 SIR-Spheres) directly to liver tumors that cannot be surgically removed. The goal was to see how well this approach controls the cancer and affects survival. Only one person took part, so res…
Sponsor: Methodist Health System • Aim: Disease control
Last updated May 14, 2026 12:04 UTC
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New antibiotic shows promise for diabetic foot infections
Disease control CompletedThis study looked at how safe and effective the antibiotic omadacycline is for treating moderate to severe diabetic foot infections, including bone infections, in hospitalized adults. Researchers compared 42 patients who received omadacycline to a similar group who got standard a…
Sponsor: Methodist Health System • Aim: Disease control
Last updated May 11, 2026 20:40 UTC
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Cheap antibiotic may prevent deadly infection in liver patients
Prevention CompletedThis study looked at whether doxycycline, a common antibiotic, can prevent spontaneous bacterial peritonitis (SBP) in people with cirrhosis. SBP is a serious infection of the fluid in the belly. The study included 841 adults with cirrhosis who were at risk for SBP. Researchers co…
Sponsor: Methodist Health System • Aim: Prevention
Last updated May 20, 2026 11:55 UTC
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Inhaler may ease nausea after Weight-Loss surgery
Symptom relief CompletedThis study tested whether a nausea relief inhaler can help reduce nausea and vomiting after bariatric (weight-loss) surgery. Fifty adults aged 18 to 65 who had the surgery were included. The goal was to see if the inhaler could lessen the need for extra nausea medications and imp…
Phase: NA • Sponsor: Methodist Health System • Aim: Symptom relief
Last updated May 18, 2026 11:59 UTC
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Freezing pain away: new hope for broken ribs?
Symptom relief CompletedThis small study tested a procedure called cryoanalgesia, which uses cold to temporarily freeze nerves and relieve pain from broken ribs. The goal was to see if this approach could control pain better than standard treatments and reduce the need for strong painkillers. Five adult…
Sponsor: Methodist Health System • Aim: Symptom relief
Last updated May 15, 2026 11:54 UTC
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Mindfulness may ease stress for liver patients
Symptom relief CompletedThis study looked at whether mindfulness exercises can lower stress and improve communication between patients with liver disease and their doctors. 56 adults took part. Researchers measured stress, anxiety, and how well patients felt they could share in decisions about their car…
Sponsor: Methodist Health System • Aim: Symptom relief
Last updated May 14, 2026 12:02 UTC
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New liver policy may drive up transplant costs, study finds
Knowledge-focused CompletedThis study looked at 186 adults who had a liver transplant at one hospital. Researchers compared costs and transplant numbers before and after a new national policy that changed how donated livers are shared. The goal was to understand if the policy led to higher costs for the tr…
Sponsor: Methodist Health System • Aim: Knowledge-focused
Last updated May 26, 2026 06:58 UTC
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Office-Based vascular procedures: safe and effective for thousands?
Knowledge-focused CompletedThis study looked at over 26,000 adults who had vascular procedures (like treating blocked arteries or varicose veins) in a doctor's office instead of a hospital. The goal was to see how often people went home safely versus needing emergency care or hospital admission. The result…
Sponsor: Methodist Health System • Aim: Knowledge-focused
Last updated May 26, 2026 06:58 UTC
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AI trains nurses to defuse workplace tensions
Knowledge-focused CompletedThis study tested a training program that uses artificial intelligence to help charge nurses improve how they handle conflicts. 35 nurses completed the program, and researchers measured their confidence in managing difficult situations. The goal was to support a healthier work en…
Sponsor: Methodist Health System • Aim: Knowledge-focused
Last updated May 26, 2026 06:57 UTC
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Vaccinated still getting COVID? study investigates breakthrough cases
Knowledge-focused CompletedThis study looked at 100 fully vaccinated adults who later tested positive for COVID-19. Researchers compared infection rates between people who only had the initial vaccine series and those who also got a booster shot. The goal was to understand how often breakthrough infections…
Sponsor: Methodist Health System • Aim: Knowledge-focused
Last updated May 26, 2026 06:57 UTC
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Pharmacists to the rescue: study shows how they fix discharge prescriptions
Knowledge-focused CompletedThis study looked at how emergency pharmacists used a special agreement to write prescriptions for patients after they left the hospital, solving issues like missing or incorrect medications. Researchers reviewed 350 patients' records to count the prescriptions sent and check if …
Phase: NA • Sponsor: Methodist Health System • Aim: Knowledge-focused
Last updated May 26, 2026 06:55 UTC
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550 COVID-19 Patients' data analyzed to track treatments and outcomes
Knowledge-focused CompletedThis study gathered information from 550 adults treated for COVID-19 at Methodist Health System facilities. Researchers looked at patient details, treatments given, and how well patients recovered. The goal was to learn more about the disease and improve future care.
Sponsor: Methodist Health System • Aim: Knowledge-focused
Last updated May 26, 2026 06:52 UTC
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Blood shortages during pandemic put surgeries at risk
Knowledge-focused CompletedThis study looked at blood product shortages during the COVID-19 pandemic at a Dallas hospital. Researchers tracked when emergency surgeries were delayed or couldn't get needed blood. The goal is to create better policies for handling blood supply during future health crises.
Sponsor: Methodist Health System • Aim: Knowledge-focused
Last updated May 26, 2026 06:52 UTC
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New study looks at best acyclovir dose for obese patients with brain infection
Knowledge-focused CompletedThis study looked back at medical records of 50 obese adults (BMI over 30) who were treated for HSV encephalitis, a serious brain infection, with the drug acyclovir. The goal was to see if using ideal body weight or adjusted body weight to calculate the dose changed the chance of…
Sponsor: Methodist Health System • Aim: Knowledge-focused
Last updated May 26, 2026 06:52 UTC
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Study examines better ways to treat blocked bowel
Knowledge-focused CompletedThis study looked back at medical records of 504 adults with small bowel obstruction to see if using a water-soluble contrast study helps patients recover faster and safer. The goal was to find ways to shorten hospital stays and reduce complications. No new treatments were tested…
Sponsor: Methodist Health System • Aim: Knowledge-focused
Last updated May 26, 2026 06:50 UTC
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Hospital heparin use under the microscope: did they follow the rules?
Knowledge-focused CompletedThis study looked back at how 100 hospitalized adults were given the blood thinner heparin to treat or prevent blood clots. Researchers checked if doctors and nurses followed the standard dosing guidelines based on blood test results. The goal was to find where mistakes happen so…
Sponsor: Methodist Health System • Aim: Knowledge-focused
Last updated May 26, 2026 06:49 UTC
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Heart patients step up recovery with wearable trackers
Knowledge-focused CompletedThis study looked at whether wearing an activity monitor after heart surgery helps patients get moving sooner and return to their normal activity levels faster. Twelve adults who had cardiovascular surgery and could walk without help wore a wrist device to track their steps and m…
Sponsor: Methodist Health System • Aim: Knowledge-focused
Last updated May 26, 2026 06:49 UTC
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Emergency surgery safe for pregnant women, small study finds
Knowledge-focused CompletedThis study looked at pregnant women who needed emergency surgery for problems like appendicitis or gallbladder disease. Researchers wanted to see if the surgery affected the baby's health. They found that emergency surgery did not harm the baby. The study was small, with only 3 p…
Sponsor: Methodist Health System • Aim: Knowledge-focused
Last updated May 26, 2026 06:48 UTC
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Phone overload: study tests if smartphones burn out nurse managers
Knowledge-focused CompletedThis study looked at whether using personal smartphones for work hurts work-life balance and increases burnout in nurse managers who oversee more than 50 staff. Six nurse managers tried different communication strategies and reported their stress levels before and after. The goal…
Sponsor: Methodist Health System • Aim: Knowledge-focused
Last updated May 26, 2026 06:48 UTC
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Tiny camera system may help doctors spot bile duct problems
Knowledge-focused CompletedThis study tested a special imaging system called NvisionVLE® in 3 patients with bile duct disease. The goal was to see if it is safe and helps doctors better see and treat bile duct issues. The study is already completed, and results will help improve future care.
Sponsor: Methodist Health System • Aim: Knowledge-focused
Last updated May 26, 2026 06:46 UTC
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Healthcare workers speak out: new study reveals hidden violence on the job
Knowledge-focused CompletedThis study surveyed 3,000 healthcare workers to find out how often they experience workplace violence, including physical and verbal attacks. The goal was to measure the impact on workers' well-being and patient care. Results will help improve reporting and support for staff.
Sponsor: Methodist Health System • Aim: Knowledge-focused
Last updated May 26, 2026 06:45 UTC
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Can a chaplain improve primary care? new study explores the role
Knowledge-focused CompletedThis study placed a full-time chaplain in a primary care clinic to see how often patients and doctors asked for their help and what topics were discussed. 312 adult patients took part. The goal was to understand how spiritual and emotional support can be offered in a regular doct…
Sponsor: Methodist Health System • Aim: Knowledge-focused
Last updated May 26, 2026 06:45 UTC
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Researchers uncover hidden links in NASH liver disease severity
Knowledge-focused CompletedThis study examined medical records of 263 adults with biopsy-confirmed NASH to see how factors like age, other health problems, and medications relate to the severity of liver scarring. Researchers focused on metabolic syndrome components as potential risk factors. No treatments…
Sponsor: Methodist Health System • Aim: Knowledge-focused
Last updated May 26, 2026 06:44 UTC
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Does your weight matter when treating septic shock?
Knowledge-focused CompletedThis study looked at 945 adults with septic shock in the ICU to see if giving blood pressure medicine based on body weight works better than a standard dose. The goal was to find out which method leads to better survival and fewer side effects. Results will help hospitals choose …
Sponsor: Methodist Health System • Aim: Knowledge-focused
Last updated May 22, 2026 14:03 UTC
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Rare male breast cancer cases examined in small study
Knowledge-focused CompletedThis study looked at the medical records of 8 men diagnosed with breast cancer at Methodist Health System. The goal was to learn more about their backgrounds, how the disease progressed, and what happened after treatment. The information gathered helps doctors better understand t…
Sponsor: Methodist Health System • Aim: Knowledge-focused
Last updated May 22, 2026 14:03 UTC
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New tool aims to predict medication side effects before they send you back to the ER
Knowledge-focused CompletedThis study tested a risk prediction tool (ADE-RED) to identify emergency department patients at high risk for serious drug side effects that could lead to hospitalization. Researchers enrolled 471 adults and tracked whether the tool helped reduce return visits or hospital stays. …
Sponsor: Methodist Health System • Aim: Knowledge-focused
Last updated May 22, 2026 14:03 UTC
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Does extra weight complicate hospital stays for injured seniors?
Knowledge-focused CompletedThis study examined how obesity impacts hospital stays and recovery in trauma patients aged 60 and older. Researchers compared obese and non-obese patients to see if weight affected length of stay, complications, or treatment costs. The goal was to clarify conflicting evidence an…
Sponsor: Methodist Health System • Aim: Knowledge-focused
Last updated May 22, 2026 13:54 UTC
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ICU study reveals hidden dangers of repeated antibiotics
Knowledge-focused CompletedThis study looked at 197 ICU patients with gram-negative bacterial infections to see if using the same antibiotic as before leads to more drug resistance. Researchers compared patients who got the same antibiotic again versus those who got a different one. The goal was to underst…
Sponsor: Methodist Health System • Aim: Knowledge-focused
Last updated May 22, 2026 13:52 UTC
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Thousands of patient surveys analyzed to improve neurosurgery experience
Knowledge-focused CompletedThis study reviewed Press Ganey surveys from 1,800 patients who visited neurosurgery clinics or hospitals between 2016 and 2020. The goal was to see how patients rated their doctors, nurses, and overall care, and to find trends over time. No treatments were tested—this was purely…
Sponsor: Methodist Health System • Aim: Knowledge-focused
Last updated May 22, 2026 13:51 UTC
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New registry tracks AAA surgery outcomes to boost patient safety
Knowledge-focused CompletedThis study created a large registry to track what happens to people after surgery for an abdominal aortic aneurysm (AAA). Researchers collected data from 394 patients aged 50 and older who had AAA repair at hospitals in North Texas. The goal was to monitor survival, need for repe…
Sponsor: Methodist Health System • Aim: Knowledge-focused
Last updated May 20, 2026 11:55 UTC
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Frailty index may predict trauma outcomes in seniors
Knowledge-focused CompletedThis study tested a simple frailty score (TSFI) in 500 older adults (65+) with physical trauma to see if it could predict complications and death better than age alone. Researchers collected data from multiple hospitals to confirm the score's accuracy. The goal is to help doctors…
Sponsor: Methodist Health System • Aim: Knowledge-focused
Last updated May 18, 2026 12:07 UTC
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Small study probes bleeding danger in emergency surgery for blood thinner users
Knowledge-focused CompletedThis completed study looked at 4 emergency surgery patients who were taking blood thinners like DOACs, warfarin, or antiplatelets. The goal was to see if those on DOACs had more bleeding or needed extra procedures to stop bleeding. The study aimed to gather information to help gu…
Sponsor: Methodist Health System • Aim: Knowledge-focused
Last updated May 18, 2026 12:01 UTC
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COVID-19 patients often had other infections, study finds
Knowledge-focused CompletedThis study reviewed medical records of 417 adults hospitalized with COVID-19 at four hospitals. Researchers wanted to find out how many patients also had other infections (co-infections) or got new infections later. They also looked at whether these extra infections affected deat…
Sponsor: Methodist Health System • Aim: Knowledge-focused
Last updated May 18, 2026 11:58 UTC
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New registry aims to save more limbs after trauma
Knowledge-focused CompletedThis study created a large database of information from nearly 1,000 adult trauma patients with severe arm or leg injuries. Researchers collected details like injury type, treatments received, and outcomes to find ways to improve survival and limb-saving care. The goal was to sup…
Sponsor: Methodist Health System • Aim: Knowledge-focused
Last updated May 15, 2026 11:56 UTC
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New study tracks brain injury in seniors to improve care
Knowledge-focused CompletedThis study gathered information from 69 older adults (age 40 and up) who had a traumatic brain injury (TBI) confirmed by CT scan. Researchers looked at patients' health history, frailty, and treatments to find patterns that lead to better recovery. No new treatments were tested—t…
Sponsor: Methodist Health System • Aim: Knowledge-focused
Last updated May 14, 2026 12:03 UTC
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Hospital screening study sees if superbug swabs predict future infections
Knowledge-focused CompletedThis study checked if testing patients for certain drug-resistant bacteria (called MDR gram-negative organisms) when they enter the hospital can predict if they will later get an infection from those same germs. Researchers looked back at records of nearly 2,900 adult patients wh…
Sponsor: Methodist Health System • Aim: Knowledge-focused
Last updated May 13, 2026 15:59 UTC
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ICU pneumonia study reveals antibiotic resistance patterns
Knowledge-focused CompletedThis study looked at hospital records of 132 ICU patients with pneumonia to find out why some infections are resistant to common antibiotics. The goal was to identify risk factors for drug-resistant bacteria. The results may help doctors choose better treatments for these serious…
Sponsor: Methodist Health System • Aim: Knowledge-focused
Last updated May 05, 2026 11:55 UTC