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Cheap antibiotic may prevent deadly infection in liver patients

NCT ID NCT04153604

Prevention Sponsor: Methodist Health System Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looked at whether doxycycline, a common antibiotic, can prevent spontaneous bacterial peritonitis (SBP) in people with cirrhosis. SBP is a serious infection of the belly fluid that can be life-threatening. The study included 841 adults with cirrhosis who were at risk for SBP. Researchers compared doxycycline to standard treatments to see if it worked just as well at preventing infection and was safe to use.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

841 people

The number who actually took part.

Started

Nov 2019

Finished

Aug 2020

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Patients hospitalized at MDMC at the Liver Institute Clinic with a diagnosis of SBP based on ascitic fluid PMN count greater than 250 cells/mm3 from July 2014 to July 2018.

Ages

18 years and older

Sex

Female participants only

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients ≥ 18 year-old with refractory ascites who are candidates for SBP prophylaxis per clinician's decision * Patients diagnosed with cirrhosis based on clinical criteria * Patients with a diagnosis of SBP confirmed by paracentesis Exclusion Criteria: * Patients who have secondary peritonitis other than SBP * Patients who have a history of liver transplant prior to the initial episode of SBP * Patients with incomplete medical records

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Conditions

The condition(s) this trial relates to.

cirrhosis of liver Fibrosis infectious peritonitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Cirrhosis Spontaneous bacterial peritonitis

Contacts and locations

Locations

  • Methodist Dallas Medical Center

    Dallas, Texas, 75203, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.