Jonsson Comprehensive Cancer Center

This study tests whether the drug acalabrutinib can help prevent relapse in people with very high-risk large B-cell lymphoma after they have received cell therapy (stem cell transplant or CAR T-cells). About 24 adults aged 18-70 will take acalabrutinib as a maintenance treatment.…

This early-phase study tests a type of internal radiation called brachytherapy for people with large kidney cancers (4-10 cm) that cannot be surgically removed or ablated. The treatment places a temporary radiation source directly into the tumor to kill cancer cells and slow grow…

This study tests a drug called ivonescimab in 25 adults with thymic carcinoma that has already been treated or cannot be treated with standard therapies. The drug helps the immune system attack cancer cells and may slow tumor growth. The main goal is to see how many patients' tum…

This study tests whether the immunotherapy drug pembrolizumab can help the immune system clear high-grade cervical precancerous cells, potentially avoiding surgery. About 25 women with CIN 2 or 3 (moderate to severe cervical precancer) will receive the drug and be monitored for 6…

This early study tests whether dapagliflozin, a drug approved for diabetes and heart failure, is safe and tolerable when given before surgery to people with stage IA lung adenocarcinoma. About 48 participants will take the drug for a short time before their planned surgery. The g…

This study tests a combination of two drugs, telisotuzumab vedotin and osimertinib, in people with a type of advanced lung cancer (non-small cell lung cancer) that has stopped responding to osimertinib alone. The cancer must have a specific gene change (EGFR mutation) and a high …

This study looks at whether giving a second course of a radioactive drug called 177Lu-PSMA-617 can help people with advanced prostate cancer that no longer responds to hormone therapy. Participants must have already benefited from an initial round of this treatment. The goal is t…

This study tests a type of internal radiation therapy (HDR-BT) that targets only the tumor in the prostate, rather than the whole gland. The goal is to control the cancer while reducing long-term urinary and sexual problems often caused by standard treatments. About 45 men with e…

This early-phase study tests whether a short course of radiation followed by chemotherapy can shrink advanced rectal tumors enough to avoid surgery. About 25 people with stage II or III rectal cancer will receive this treatment. The goal is to preserve the rectum and improve qual…

This study tests whether giving two drugs (pembrolizumab and enfortumab vedotin) before and after surgery can improve outcomes for people with high-risk upper tract urothelial cancer. About 21 adults will receive the drugs before having their kidney and ureter removed, then conti…

This study is for men whose prostate cancer has come back and spread to a few other places in the body. It compares two radioactive drugs (225Ac-PSMA-617 and 177Lu-PSMA-617) given together with precise, high-dose radiation to the tumors. The goal is to see which combination works…

This study is for people with a type of advanced prostate cancer that has spread and stopped responding to standard treatments. It compares the usual fixed schedule of 6 doses of a radioactive drug (Lu-PSMA) given every 6 weeks to a flexible schedule that allows up to 12 doses wi…

This study is for people with head and neck cancer who cannot or choose not to receive standard treatments. It tests a new radiation method called PULSAR combined with advanced planning technology (HyperArc) to deliver higher, more targeted doses of radiation. The goal is to bett…

This study tests a drug called trastuzumab deruxtecan, which delivers chemotherapy directly to cancer cells with low HER2 levels, given alone or with anastrozole (a hormone blocker). About 88 people with early-stage, hormone receptor positive breast cancer will receive treatment …

This study tests a treatment called radioembolization for people with early-stage kidney cancer. Tiny glass beads containing a radioactive substance are injected into the artery feeding the tumor to destroy it from inside. The goal is to see if this approach is safe and effective…

This early-stage trial tests a new drug called ERAS-801 in 10 adults with a type of aggressive brain cancer (glioblastoma) that has come back or worsened. The drug targets a specific protein (EGFR) found on many of these tumor cells and is designed to reach the brain. The main go…

This study tests a new radiation approach for adults with soft tissue sarcoma. Instead of weeks of daily radiation, patients receive higher doses over just 5 days before surgery. The goal is to see if this shorter course is safe, causes fewer long-term side effects like stiffness…

This study tests the drug tarlatamab in people with advanced tumors that have a protein called DLL3. The goal is to see if the drug can shrink or control these tumors. About 29 adults with advanced DLL3-expressing cancers will receive tarlatamab and be monitored for response and …

This study tests whether adding two new drugs (zimberelimab and quemliclustat) to standard chemotherapy can help shrink pancreatic tumors that are either borderline removable or have spread locally. The goal is to make surgery possible and improve survival. About 56 adults with u…

This large trial tests whether an FDA-approved artificial intelligence tool helps radiologists detect breast cancer more accurately on screening mammograms. About 400,000 adult women across six U.S. health systems will have their mammograms read either with or without AI assistan…

This study tests a new PET scan tracer called Me-4FDG to see if it can find lung cancer earlier and more accurately. About 60 adults with lung nodules will get the tracer and a PET scan. The goal is to improve early diagnosis and reduce unnecessary procedures.

This study tests whether a special PET/CT scan using flotufolastat F 18 can accurately find prostate cancer that remains or returns after focal therapy. About 81 men who had focal therapy in the past 6-36 months will get the scan. If successful, this imaging method could offer a …

This study aims to find a less invasive way to diagnose thyroid cancer using blood samples instead of traditional biopsies. Researchers will analyze tiny particles called extracellular vesicles from the blood and tissue of 250 adults with suspicious thyroid nodules or known thyro…

This study tests whether a special PET/CT scan using a radioactive tracer (flotufolastat F 18) can better guide prostate biopsies than standard MRI. About 30 men with suspicious MRI findings will get both types of scans before biopsy. The goal is to see if the new method finds mo…

This study tests two advanced MRI techniques to better tell apart brain tumors that have come back from tissue damage caused by radiation therapy. About 42 adults with brain metastases will be scanned before surgery or radiation. The goal is to help doctors choose the right treat…

This study tests whether community health advocates can help more people get screened for breast and lung cancer. Researchers will work with 800 eligible adults to see if support from friends and family increases screening rates. The goal is to understand and overcome barriers, e…

This study tests a special radiation technique for prostate cancer that uses MRI scans to map and protect the nerves and blood vessels needed for erections. About 200 men will receive either this new approach or standard radiation. The goal is to see if the new method reduces sex…

This study tests a weight loss program using a smartphone app and a coach for teens and young adults who are overweight after a stem cell transplant. The goal is to help them lose weight and build healthy eating habits. About 20 people will join, and researchers will track change…

This study compares virtual reality (VR) and music relaxation to standard care for reducing anxiety and pain in women undergoing breast biopsies. About 600 women will be randomly assigned to one of three groups: VR, music, or usual care. Researchers will measure anxiety and pain …

This study tests a new way to deliver radiation for prostate cancer that hasn't spread. Instead of using a single treatment plan, doctors adjust the radiation daily based on real-time MRI or CT scans to better target the tumor and avoid healthy tissue. The goal is to see if this …

This study tests a new way to deliver radiation for prostate cancer that hasn't spread. By using real-time tracking to adjust the beam as the prostate moves, doctors hope to reduce urinary and bowel side effects. The study will enroll 80 men with early-stage prostate cancer to se…

This study tests a program to help patients with high-risk colon polyps get a follow-up colonoscopy within the recommended 3 years. The program works with clinics, doctors, and patients to make scheduling easier and remind people of the importance of this screening. About 1,680 a…

This early-phase trial is testing whether fluoxetine (Prozac), a common antidepressant, can alter the immune cells inside colorectal tumors. About 10 adults with untreated colorectal cancer will take fluoxetine before their scheduled surgery. Researchers will compare tumor sample…

This study uses MRI scans to look at brain tumor biology in 50 adults with glioblastoma that can be surgically removed. The goal is to find imaging markers that can predict which patients will benefit from the drug bevacizumab. Participants will have their tumors analyzed for a p…

This study looks at how endocrine therapy, a common breast cancer treatment, affects brain function and thinking skills in 120 women aged 35-65. Researchers will compare brain scans and cognitive tests between survivors on therapy and healthy women, focusing on the role of menopa…

This early-phase study tests a special PET scan that uses a radioactive tracer to find immune cells (CD8+ T-cells) inside brain tumors. About 20 adults with brain tumors scheduled for surgery will receive the tracer before their operation. The goal is to see if this imaging metho…

This study looks at why some prostate cancers become resistant to a treatment called 177Lu-PSMA, which delivers radiation directly to cancer cells. Researchers will take small tissue samples (biopsies) from tumors in 30 men with advanced prostate cancer that has spread. The goal …

This study collects blood and saliva samples from 2000 cancer patients to learn how inherited genetic changes influence cancer risk, tumor behavior, and response to treatment. By comparing these samples with large genetic databases, researchers hope to better understand why some …

This study tests a clinic-wide program called Primary Care-GI Connect to improve follow-up colonoscopy rates in people who had an abnormal stool-based colorectal cancer screening test (FIT). The program helps coordinate care, standardize referrals, and engage doctors. About 1,500…

This study explores whether growing a patient's tumor cells in the lab (as organoids) can help doctors predict which chemotherapy drugs will work best for that individual. Researchers will collect tissue from biopsies or surgeries of 40 people with suspected or confirmed osteosar…

This study is testing a new combined MRI and PET scan to measure how brain tumors use energy. Researchers will compare scan results with tissue samples from 50 adults with glioblastoma who need surgery. The goal is to improve imaging, not to treat the disease directly.

This study tests three advanced MRI methods to look at the cells and proteins around glioblastoma brain tumors without needing surgery. Researchers want to understand why some tumors are harder to treat. About 15 adults with suspected glioblastoma will have these special scans be…

This early study tests a radioactive imaging agent called 99mTc-PSMA-I&S in 30 men with prostate cancer who are scheduled for lymph node removal surgery. The goal is to see how the agent spreads in the body and whether it can help surgeons detect cancer that has spread to lymph n…