Jonsson Comprehensive Cancer Center

This early-phase trial tests a custom-made vaccine for people with a rare and aggressive brain cancer called diffuse hemispheric glioma with an H3 G34 mutation. The vaccine is made from the patient's own immune cells and is designed to teach the body to attack the tumor. The main…

This study tests a combination of radiation therapy and two immunotherapy drugs (durvalumab with or without tremelimumab) in people with advanced bladder cancer that cannot be surgically removed or has spread. Participants either cannot have chemotherapy or have chosen not to. Th…

This study tested a new way of giving radiation therapy (called hypofractionated radiotherapy with a stereotactic boost) along with standard chemotherapy for people with stage II or III non-small cell lung cancer that cannot be removed by surgery. The goal was to find the highest…

This study tests a special type of radiation called stereotactic body radiotherapy (SBRT) for men with high-risk prostate cancer that has not spread. The treatment delivers a very focused, high dose of radiation to the tumor to kill cancer cells while sparing nearby healthy tissu…

This study tests a combination of three drugs (niraparib, temozolomide, and atezolizumab) in people with advanced solid tumors or extensive-stage small cell lung cancer that responded to initial chemotherapy. The goal is to find the safest dose and see if the combo helps keep can…

This study tests a combination of hormone therapy (leuprolide, apalutamide, abiraterone) and precise radiation (SBRT) in 28 men whose prostate cancer has returned and spread to a few spots. The goal is to see if this approach can lower PSA levels to nearly undetectable. Participa…

This study tests a combination of two drugs, talazoparib and temozolomide, in people with extensive-stage small cell lung cancer that has come back or not responded to initial chemotherapy. The goal is to see if this combination can shrink tumors or slow cancer growth. About 35 a…

This early-stage study tests whether adding an experimental drug (BO-112) to an immunotherapy (nivolumab) before surgery is safe for people with soft tissue sarcoma that can be removed. The goal is to see if this combination can boost the immune system to better attack the cancer…

This early-stage trial is testing a new type of immunotherapy for people with certain blood cancers (like lymphoma and leukemia) that have returned or not responded to standard treatments. The therapy uses a patient's own immune cells, which are modified in a lab to better recogn…

This study tests a combination of targeted drugs (ribociclib, tucatinib, trastuzumab) with or without hormone therapy (fulvestrant) for HER2-positive breast cancer. In the first part, it checks safety in patients whose cancer has spread. In the second part, it compares this combo…

This study tests a new approach for people with advanced cancers that have not responded to standard treatments. Doctors take a patient's own white blood cells, genetically reprogram them to recognize a protein called NY-ESO-1 found on cancer cells, and give them back along with …

This study tests a precise type of radiation called stereotactic body radiotherapy (SBRT) in 92 men who had prostate cancer surgery but still have signs of cancer, like rising PSA levels. The goal is to see if SBRT can stop the cancer from coming back while limiting side effects.…

This early-phase trial studies whether adding the immunotherapy drug pembrolizumab to standard chemotherapy can help people with rare, aggressive small cell or neuroendocrine cancers of the bladder or prostate. About 15 participants with cancer that has spread will receive the co…

This study is for people with advanced gynecologic cancers (ovarian, endometrial, or cervical) that no longer respond to standard platinum chemotherapy. It combines internal radiation (brachytherapy) with two immunotherapy drugs, durvalumab and tremelimumab, to boost the immune s…

This study tests whether adding two antibody drugs (necitumumab and trastuzumab) to the standard pill osimertinib can shrink tumors in people with advanced EGFR-mutated lung cancer that has stopped responding to osimertinib alone. About 30 adults with stage IV non-small cell lung…

This study tests a new type of MRI that looks at sodium and other signals in the brain to get a clearer picture of tumors. It includes healthy volunteers and people with brain tumors (glioma) that are new or have returned. The goal is to improve how doctors detect, understand, an…

This study looks at whether a special type of scan called SPECT/CT can help doctors decide the best way to manage kidney tumors. About 100 adults with a new kidney tumor between 1.5 and 5.0 cm are taking part. The scan may provide useful information that changes treatment plans, …

This study compares two genetic tests (Afirma and ThyroSeq) for thyroid nodules that have unclear biopsy results. The goal is to see which test better identifies harmless nodules, so more patients can safely avoid surgery and maintain their quality of life. About 328 adults with …

This study explores whether a PET scan using a special tracer (68Ga-PSMA-11) can help guide prostate biopsies to find serious prostate cancer more accurately. It involves 30 men who had a previous biopsy that was negative or unclear. The goal is to improve detection and reduce bo…

This study looks at whether Tai Chi, a gentle mind-body exercise, can improve chronic insomnia in breast cancer survivors. About 90 women who have finished cancer treatment and have had trouble sleeping for at least 6 months will participate. The goal is to see if Tai Chi helps t…

This study compares two types of image-guided radiation therapy for prostate cancer: one using CT scans and the other using MRI. The goal is to see if MRI guidance reduces short-term side effects like urinary or bowel problems. About 179 men with localized prostate cancer will re…

This study tests if a liquid meal replacement called Soylent can help people with head and neck cancer avoid needing a feeding tube during chemotherapy and radiation. About 60 patients will drink Soylent regularly to see if it prevents malnutrition and reduces feeding tube use. T…

This study tests whether a plant-based pea protein drink can reduce the need for feeding tubes in people with head and neck cancer undergoing chemoradiation. Feeding tubes can cause long-term swallowing problems. The drink is designed to be easy to digest and free of common aller…

This early-phase study tests a new imaging tracer called 68Ga-FAPI-46 in 26 people with various cancers. The tracer targets cells around tumors, helping PET scans show where cancer is located. Researchers want to see how well the tracer works and compare it to standard imaging. T…

This study tests a video-based educational program for people who have had uveal melanoma, a rare eye cancer. The goal is to see if the program helps survivors better understand their illness and feel less anxious or depressed. About 108 adults who received treatment at UCLA are …

This study is a registry that follows people who have had cryoablation (freezing) for early-stage breast cancer. Researchers will track side effects, symptoms, imaging results, and any future cancer treatments. Only 2 participants are enrolled, so this is a very small observation…

This study tests a program to increase colorectal cancer screening among low-income and ethnic minority groups, who are often hit harder by this cancer. Researchers will help clinics and doctors encourage eligible patients (ages 50-75) to complete a simple at-home stool test (FIT…

This study looks at whether a DNA-based test can help predict which prostate cancer patients are more likely to have side effects from radiation therapy. About 208 men with early-stage prostate cancer will have their DNA tested for a marker linked to radiation sensitivity. Doctor…