Istituto Ortopedico Rizzoli

This study tests a custom-made, 3D-printed ankle and talus replacement for people with severe ankle arthritis or bone damage. The implant is designed to fit each patient perfectly, preserving more natural movement and reducing surgery impact. Researchers will follow 26 participan…

This study looks at how well a metal implant anchored directly to the thigh bone works for people who have lost a leg above the knee. The implant replaces the traditional socket, which often causes skin sores and pain. Researchers will track 15 participants to see if the implant …

This study tests a new surgical method for meniscal root tears, where the torn meniscus is stitched to the posterior cruciate ligament. The goal is to restore knee stability and prevent arthritis. About 59 adults aged 18-50 will be followed for 2 years with MRI and ultrasound to …

This study is testing a triphasic scaffold to help repair knee cartilage in people with osteochondritis dissecans (OCD), a condition where cartilage and bone separate. The scaffold is implanted during surgery to support new tissue growth. Researchers will follow 30 patients aged …

This study tests a special patch made from donated human skin, combined with the patient's own bone marrow cells, to repair large rotator cuff tears. The goal is to see if this approach lowers the chance of the tendon tearing again after surgery. About 72 adults with severe tears…

This study is testing custom-made, 3D-printed hip implants for 15 adults whose previous hip treatments failed and who have severe bone loss. The implants are designed from CT scans to fit each person's unique bone damage. Researchers will track complications, pain, mobility, and …

This study is testing a procedure called arterial chemoembolization for people with desmoid tumors that are growing and causing pain. The treatment delivers a chemotherapy drug (doxorubicin) directly into the tumor's blood supply to shrink it and reduce pain, while limiting side …

This study is testing whether a new silver-coated hip replacement device can lower the chance of infection in people at high risk, such as those with diabetes or weak immune systems. About 70 participants will receive the implant and be monitored for infections and silver levels …

This study tests a new surgical technique for people with ankle bone and cartilage defects that cause pain and swelling. The procedure uses a special scaffold filled with the patient's own bone marrow cells, placed under the cartilage to help it heal. The goal is to see if this a…

This study tests whether ankle replacements custom-designed from a patient's own CT scans work better than standard implants. About 24 adults with ankle arthritis will receive either a personalized or standard artificial ankle. Researchers will measure bone alignment, patient sat…

This study compares knee realignment surgery alone versus realignment plus a donor meniscus transplant in 52 adults aged 20-60 with knee osteoarthritis and a missing meniscus. The goal is to see if the combined approach provides better pain relief, function, and joint protection.…

This study looks at a treatment for desmoid tumors, which are rare but painful growths. Instead of using chemotherapy, doctors will block the blood supply to the tumor using tiny particles. The goal is to reduce pain, shrink the tumor, and improve quality of life. About 20 people…

This study looks at whether certain blood and joint fluid tests can more accurately diagnose infections in people who need hip or knee replacement revision surgery. Researchers will compare these tests to standard methods and also check which approach is most cost-effective. The …

This study aims to see if two simple physical exams can accurately diagnose chronic plantar fasciitis, a common cause of foot pain. Researchers will test 45 adults—some with the condition and some without—to measure how well these exams work. The goal is to make diagnosis quicker…

This study tests ways to prevent foot ulcers in people with type-2 diabetes. It includes 150 adults who are either at mild-to-moderate risk of developing a foot ulcer or have had one that healed at least 6 months ago. Researchers will check blood markers for inflammation and revi…

This study looks at whether adding online physical therapy sessions to in-person rehab helps people recover just as well after total hip replacement. About 104 adults aged 50 to 80 who had hip surgery will take part. Researchers will compare pain, function, and satisfaction betwe…

This study tests whether combining two types of injections—platelet-rich plasma (PRP) and hyaluronic acid—works better than either alone for knee osteoarthritis. About 288 adults aged 40-75 with knee pain will receive one of three treatments and be monitored for changes in pain, …

This study tests whether platelet-rich plasma (PRP) with or without white blood cells works better for hip osteoarthritis. 230 adults with mild to moderate hip arthritis will receive ultrasound-guided injections and be followed for a year. The goal is to see which type reduces pa…

This study is testing whether a procedure called arterial embolization can reduce pain and improve quality of life in people with bone metastases (cancer that has spread to the bones). The procedure blocks blood flow to the tumor, which may shrink it and ease symptoms. Researcher…

This study tests whether using special motion sensors during knee replacement surgery leads to better results. Forty adults aged 50-85 with severe knee arthritis will receive a standard knee implant, but surgeons will use inertial sensors to guide bone cuts. Researchers will trac…

This study tests whether virtual reality (VR) can reduce anxiety and pain in children aged 7 to 12 during minor orthopedic surgery. Half the children will use a VR headset with calming environments before and during surgery, while the other half receives standard sedative medicat…

This study tests whether a single injection of hydrolyzed collagen into the knee can reduce pain and improve function in people with knee osteoarthritis. About 204 adults with knee cartilage damage who have not improved with other treatments will receive either the collagen injec…

This study tests if using virtual reality for 20 minutes before a minimally invasive procedure can lower anxiety. About 236 adults will either use VR or receive standard care. Researchers will measure anxiety levels with questionnaires before and after the procedure.

This study tests whether custom-made knee replacements, designed from each patient's CT scans and made with 3D printing, fit better and cause less pain than standard off-the-shelf implants. About 20 adults aged 40-70 with knee osteoarthritis will be randomly assigned to get eithe…

This study tests a minimally invasive surgery to correct hallux valgus, commonly known as bunions. Researchers will measure pain relief and foot function in 40 adults with mild to moderate bunions. The goal is to see if this less invasive approach improves recovery and outcomes.

This study looks at two different hand therapy programs for people with De Quervain's disease, a painful thumb tendon condition. All participants first receive a standard steroid injection guided by ultrasound. Then, one group follows standard physiotherapy guidelines, while the …

This study tests whether doing physical therapy at home through video calls (telerehabilitation) is as good as going to a clinic for in-person sessions after arthroscopic rotator cuff repair. About 46 adults aged 40-70 who had shoulder surgery will be split into two groups: one d…

This study tests a procedure called transarterial microembolization (TAME) for people with knee arthritis and long-lasting pain. About 43 adults with moderate knee arthritis who haven't found relief from standard treatments will receive this minimally invasive treatment. The goal…

This study tests a new treatment for people with painful knee arthritis in both knees. Each participant gets an injection of their own fat tissue in one knee and the same fat plus hyaluronic acid in the other. The goal is to see if the combination reduces pain and improves moveme…

This study tests whether injecting platelet-rich plasma (PRP) into the elbow can reduce pain and improve function in people with tennis elbow that hasn't gotten better with other treatments. 240 adults will receive either PRP with white blood cells, PRP without white blood cells,…

This study tests whether a single injection of cells from bone marrow or from fat tissue can better reduce pain and improve knee function in people with knee osteoarthritis. Researchers will enroll 204 adults aged 40 to 75 who have not gotten relief from standard treatments. The …

This study compares two injection treatments—fresh PRP (platelet-rich plasma) and hyaluronic acid—for people with patellofemoral osteoarthritis (knee arthritis). The goal is to see which one better reduces pain and improves knee function over 12 months. The trial is recruiting 16…

This study looks at how pain and the ability to walk change in the first days after a limb amputation. Researchers will review medical records of 150 adults who had an amputation. The goal is to better understand recovery patterns, not to test a new treatment.

This study looks at how surgeons can measure knee looseness during operations to repair or replace the anterior cruciate ligament (ACL) or transplant a meniscus. About 1,500 people aged 14 to 65 having these surgeries will take part. The goal is to gather data using a special nav…

This study follows 150 people whose high-grade osteosarcoma returned near the original tumor site. Researchers will look at medical records to find factors that affect how long patients live after the cancer comes back. The goal is to learn more about the disease, not to test a n…

This study looks at how well people with bone cancer follow a personalized home exercise program after having surgery to remove a tumor from their leg. About 50 patients will track their daily exercises for six months. The goal is to understand what helps or hinders them from sti…

This study is observing 1000 children under 18 with lower limb deformities (birth defects or acquired bone problems). Researchers will collect information from exams and questionnaires to learn more about these conditions and how they are treated. The goal is to create a better s…

This study is a registry that gathers medical, genetic, and quality-of-life information from people with Li-Fraumeni syndrome or similar conditions. The goal is to better understand how the disease develops and progresses over time. No treatments or experimental drugs are given. …

This study follows 50 people who had knee realignment surgery (high tibial osteotomy) to treat early knee arthritis. Researchers want to see how the surgery affects the kneecap joint and patellar height over many years. The goal is to better understand long-term outcomes and help…

This study compares two ways of doing total knee replacement: the standard method and one using computer-assisted navigation. Researchers will track 160 patients to see which technique leads to better knee function, less bleeding, and lower costs. The goal is to find out if the h…

This study looks at how well dissolvable screws work to fix loose pieces of cartilage in the knee. It includes 100 people aged 12 to 35 who had this surgery. The goal is to see if this method helps prevent long-term problems like arthritis and chronic pain.

This study tests whether a special tensioner tool helps surgeons better balance the ligaments during total knee replacement compared to the usual technique. About 200 adults getting a specific knee implant will be split into two groups, one using the tensioner and one using stand…

This study looks at how well patients recover after surgery for a torn biceps tendon. Researchers will check 30 patients at least 2 years after their operation using physical exams, strength tests, and X-rays. The goal is to see how the elbow functions and if any complications, l…

This study looks at whether analyzing MRI images with a computer technique called radiomics can predict if a desmoid tumor will grow back after cryoablation (freezing treatment) better than current methods that only measure tumor size. Desmoid tumors are non-cancerous but can cau…

This study looks at how bone growths (osteochondromas) affect movement and body shape in children and adults. Researchers will use wearable sensors, pressure mats, and 3D body scans to measure walking, balance, and joint motion. The goal is to find simple ways to decide when surg…

This study aims to create and validate an Italian version of the New Knee Society Knee Scoring System, a questionnaire that measures knee function and symptoms in people with knee osteoarthritis. Researchers will translate the English version into Italian and test it with 200 pat…

This study is developing a new method to deliver chemotherapy drugs directly to sarcomas using tiny particles and light. Researchers will test this approach on cells and tissue samples from 30 patients with bone or soft tissue tumors. The goal is to see if the method works better…

This study looks at heart structure and function in people with osteogenesis imperfecta (OI), a condition that makes bones fragile. Researchers want to learn how often heart problems occur in people with OI. About 40 participants will have heart tests. No treatment is given; the …

This study tests a new way to help patients understand complex spine or urology surgeries before they agree to them. About 300 adults scheduled for surgery will either get the usual consent process or a new multimedia approach with videos and quizzes. The goal is to see if the ne…

This study collects information from over 200 people with fibrous dysplasia, a rare bone condition that causes abnormal growths. Researchers will look at medical records, surgeries, and genetic data to better understand the disease and how it affects patients. No new treatments a…

This study follows about 20 people who had surgery for flat feet about 10 years ago. Doctors will check if the foot shape correction has lasted and if patients have any pain. The goal is to see how well the surgery holds up over time.

This study looks at how muscle strength, power, and control affect the risk of falling in older adults with knee osteoarthritis. Researchers will measure muscle function, monitor daily movement, and use MRI scans to find better ways to predict falls. The goal is to help prevent f…

This study looks back at medical records of 300 people with multiple osteochondroma, a rare genetic condition causing bony growths. Researchers want to count and describe the surgeries these patients had, and explore a new way to score the severity of the condition. The goal is t…

This study looks at how a special dissolvable implant used to correct foot deformities in children and teens holds up over time. Researchers will use MRI scans and foot function scores to see if the implant has fully broken down after at least 5 years. About 35 people who had the…

This study follows 150 adults aged 18–70 who had knee osteotomy surgery to treat osteoarthritis caused by a crooked leg (bow-legged or knock-kneed). The goal is to see how well the knee works and feels over many years, and whether this bone-cutting technique can successfully dela…

This study looks at how consistently a tool called the Iowa Level of Assistance (ILoA) scale measures functional recovery in people who have had joint replacement surgery. About 42 patients and their physiotherapists will take part. The goal is to see if different therapists give…

This study aims to find out if markers of bone and muscle health can predict complications after spinal surgery. Researchers will collect data from 200 adults undergoing spine surgery, including imaging, tissue samples, and questionnaires about pain and quality of life. The goal …

This study looks at how bone density around a new knee joint changes over two years, comparing two common implant designs. Fifty people getting a cemented total knee replacement will have bone scans and complete surveys about their knee function. The goal is to see which implant …

This study tests whether 3D computer simulation and custom-printed surgical tools can make bone correction surgeries more precise and safer. It involves 100 children, teens, and young adults with rare limb deformities. Researchers will compare planned corrections to actual result…

This study looks at why some knee replacements loosen and fail without infection, a problem called aseptic loosening. Researchers will review X-rays and registry data from 31 patients who had revision surgery. The goal is to understand the causes and measure the financial burden …