PRP showdown: which injection eases hip pain best?
NCT ID NCT05497349
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests two versions of platelet-rich plasma (PRP) injections—one with white blood cells and one without—to see which better reduces pain and stiffness in people with hip osteoarthritis. About 230 adults with mild to moderate hip OA will receive ultrasound-guided injections and be followed for a year. The goal is to find the most effective way to ease symptoms and improve daily function.
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Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 230 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Oct 2022
- Expected to finish
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Oct 2026
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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35 to 70 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
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Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Signs and symptoms of hip OA (pain intensity of at least 4 points and not more than 8 of VAS pain - 0-10 scale in the previous week); * Radiographic signs of hip OA (Grade 1-2 according to Tonnis classification) or MRI signs (chondropathy or minimal labrum degeneration without acute lesions) even if Grade 0. * Unilateral involvement; Hemoglobin \> 11 g/dl; * Platelet count \> 150,000 plt/mm3 (Recently performed CBC examination); * Negative serological tests for HBsAg, HCV Ab, HIV-1-2 Ab * No clinically significant electrocardiographic changes (Recently performed ECG). * Ability and consent of patients to actively participate in clinical follow-up;- Signature of informed consent. Exclusion Criteria: * Patients unable to express consent; * Patients undergoing infiltration of other substance in the previous 6 months; * Patients undergoing lower limb surgery to be treated in the previous 12 months; * Patients with malignant neoplasms; * Patients with rheumatic diseases;- Patients with uncontrolled diabetes;-Patients with hematological diseases (coagulopathies); * Patients on anticoagulant-antiaggregant therapy that cannot be discontinued for at least 3 days prior to blood collection; * Patients with uncontrolled thyroid metabolic disorders; * Patients abusing alcoholic beverages, drugs or medications; * Body Mass Index \> 30; * Patients who have taken NSAIDs in the 3 days prior to blood draw; * Patients with cardiovascular disease for whom 300 ml blood draw would be contraindicated; * Patients with recently performed CBC examination with Hb\< 11 g/dl and Platelet values \< 150,000 plt/mm3. * Positive serological tests for HBsAg, HCV Ab, HIV-1-2 Ab * Pregnant and/or fertile women. * Pain intensity less than 4 points or greater than 8 in accordance with the VAS scale. * Patients with other hip pathologies: acetabular protrusion, concentric migration of the femoral head, presence of excessive deformity resulting from acetabular or femoral head dysplasia, collapse deformity, and deformed femoral head sequelae of Perthes disease or osteonecrosis of the femoral head. * Previous extensive surgery of the reference joint (osteotomy around the hip, open or arthroscopic osteochondroplasty for femoro-acetabular conflict).
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Istituto Ortopedico Rizzoli
RECRUITINGBologna, 40136, Italy
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