Institut Claudius Regaud

This Phase 3 trial is testing whether adding four cycles of chemotherapy (doxorubicin-based) to standard surgery and radiation can improve outcomes for people with high-risk soft tissue sarcoma. The study will enroll 600 participants, with 250 high-risk patients randomly assigned…

This study tests a new surgical technique called the external pudendal flap (STEPA flap) for rebuilding the mouth or throat after cancer removal. The goal is to see if it causes fewer complications at the area where the flap is taken from. About 40 patients will be followed for a…

This study tests whether adding focused radiation to standard treatment helps people with metastatic bladder cancer live longer. It includes patients whose cancer has not worsened after initial therapy and who have three or fewer remaining tumors. About 130 participants will be r…

This study is for people with a type of head and neck cancer that has come back or spread. It tests whether giving only 4 cycles of chemotherapy (instead of the usual 6) along with the immunotherapy drug pembrolizumab can still work well while causing fewer side effects. About 86…

This study looks at whether surgically removing para-aortic lymph nodes before standard chemoradiation can improve disease-free survival in people with stage IIIC1 cervical cancer. About 510 participants will be randomly assigned to either standard treatment or surgery plus tailo…

This study looks at whether medical hypnosis can help reduce anxiety in people with solid tumors who are getting radiation therapy. About 45 moderately to very anxious patients will either listen to relaxing music alone or combine it with hypnosis during their sessions. The goal …

This study is testing a new way to manage care for 33 cancer patients who take oral chemotherapy at home. Instead of going to the hospital every month just to pick up medicine, a nurse will visit them at home twice in six months. An advanced practice nurse will coordinate everyth…

This study tests a shorter course of radiation given before surgery for soft tissue sarcoma in patients aged 70 and older, or those 65 and older who are considered fragile. The goal is to see if this approach reduces major wound healing problems after surgery. About 48 participan…

This study tests if a personalized program of physical therapy, exercise, and nutrition before surgery can improve arm or leg function and quality of life for people with bone or soft-tissue sarcoma. About 53 participants will be followed for up to 24 months after surgery. The go…

This study is looking at why some ovarian cancers become resistant to platinum-based chemotherapy, a common treatment. Researchers will collect blood, tumor, and fluid samples from 600 patients over five years, alongside their medical data. No new drugs are being tested—the goal …

This study will collect blood and tumor samples from 80 people with newly diagnosed glioblastoma to find biological markers that show whether a treatment called TTFields (tumor-treating fields) is working. The goal is to understand why some patients respond and others don't. Part…

This study is investigating whether a patient's body weight changes how the drug Trastuzumab-Deruxtecan (T-DXd) behaves in the body. Researchers will compare drug levels and side effects between normal-weight and overweight or obese patients with advanced breast cancer. The goal …

This study looks at families who carry a change in the DDX41 gene, which may raise the risk of blood cancers like leukemia. Researchers will collect health questionnaires and saliva samples from up to 910 people to track who develops blood problems and when. The goal is to better…

This study looks at whether an inflammation-based score (using CRP and albumin levels) can predict how well patients with advanced intestinal neuroendocrine tumors respond to Lu-177 oxodotreotide therapy. Researchers will follow 150 patients for 36 months, collecting blood sample…

This study compares three different blood tests (CellSearch, Parsortix, and SmartCatch) to see which one is best at finding circulating tumor cells in patients with metastatic breast or prostate cancer. About 54 patients will give a blood sample before starting a new treatment. T…

This study is for people with advanced or metastatic HER2-negative breast cancer who have a BRCA1/2 gene mutation. Researchers want to find out why some tumors stop responding to PARP inhibitor drugs like olaparib or talazoparib. They will collect tumor and blood samples to look …

This study looks at the inner workings of breast cancer cells, focusing on fat droplets and proteins, in 1,050 people with early or metastatic breast cancer. Researchers will take tumor samples and analyze them in the lab to see how different subtypes differ. The goal is to learn…

This study is collecting blood and tumor samples from 1,100 people with head and neck, ovarian, cervical, lung, brain, or anal cancer. Researchers want to learn how immune cells called T cells behave in different tumors. The goal is to better understand why some cancers respond t…

This study looks at whether a blood test can find genetic changes in tumor DNA that signal ovarian cancer is coming back. It involves 130 women with BRCA mutations who are taking a maintenance drug called Olaparib after initial treatment. The goal is to see if these blood tests c…

This study tracks 770 adults with advanced solid cancers (like lung, head and neck, melanoma, or bladder cancer) who are receiving immunotherapy. Researchers collect tumor and blood samples over time to find biological markers that predict how well the treatment works or causes s…

This study follows 150 people with a GATA2 gene mutation to learn what factors predict if they will develop serious blood cancers like MDS or AML. Researchers will collect blood and bone marrow samples over 5 years and also review past data from 100 other patients. The goal is to…

This study explores whether using alternative and complementary therapies, like turmeric supplements, affects how well early-stage breast cancer patients stick to their tamoxifen treatment. Researchers will follow 200 patients for one day to measure medication adherence and tamox…

This study looks at how radiation to the brain affects memory in children who had a brain tumor. Researchers will test memory and thinking skills in 130 children ages 4 to 12, starting 2 years after radiation and again 2 years later. The goal is to learn which parts of the brain …

This study aims to better understand the immune system's role in rare soft tissue sarcomas. Researchers will collect medical information and tumor samples from 500 patients (400 new and 100 from past records) to analyze immune markers and genetic signatures. The goal is to learn …

This study looks at whether a blood test (liquid biopsy) can detect prostate cancer cells as well as a special PET scan. Researchers will compare results from 80 men with prostate cancer to see if the blood test matches the scan findings. The goal is to find a simpler way to moni…

This study looks back at data from 370 children and teens treated for ependymoma, a common brain tumor. Researchers want to understand why half of these tumors come back after surgery and radiation. They will use advanced imaging, genetics, and artificial intelligence to find pat…