Institut Claudius Regaud

This study is for people with a type of head and neck cancer that has come back or spread. It tests whether giving only 4 cycles of chemotherapy (instead of the usual 6) along with the immunotherapy drug pembrolizumab can still work well while causing fewer side effects. About 86…

This study tests whether adding 4 cycles of chemotherapy around the time of surgery can help prevent cancer from spreading in people with high-risk soft tissue sarcoma. About 600 participants will be screened, and those with a high-risk genetic marker will be randomly assigned to…

This study looks at whether surgically removing para-aortic lymph nodes before standard chemoradiation can improve disease-free survival in people with stage IIIC1 cervical cancer. About 510 participants will be randomly assigned to either standard treatment or surgery plus tailo…

This study tests a new surgical technique that uses skin from the groin area (external pudendal flap) to rebuild the mouth or throat after cancer removal. The goal is to see if this method is safe and causes fewer problems at the donor site compared to standard flaps. Up to 40 ad…

This study looks at whether adding focused radiation to standard treatment can help people with advanced bladder cancer live longer. It includes patients whose cancer has spread but who have three or fewer remaining tumors after initial chemotherapy. The goal is to see if zapping…

This study is testing a new way to manage care for 33 cancer patients who take oral chemotherapy at home. Instead of going to the hospital every month just to pick up medicine, a nurse will visit them at home twice in six months. An advanced practice nurse will coordinate everyth…

This study tests a shorter course of radiation given before surgery for soft tissue sarcoma in patients aged 70 and older, or those 65 and older who are considered fragile. The goal is to see if this approach reduces major wound healing problems after surgery. About 48 participan…

This study tests if a personalized program of physical therapy, exercise, and nutrition before surgery can improve arm or leg function and quality of life for people with bone or soft-tissue sarcoma. About 53 participants will be followed for up to 24 months after surgery. The go…

This study looks at whether adding medical hypnosis to relaxing music can lower anxiety in cancer patients who are moderately to very anxious during their radiation therapy. About 45 adults with solid tumors will be randomly assigned to either listen to music alone or listen to m…

This study collects tissue samples from 1,050 people with early or metastatic breast cancer to map how fat is stored in cells and how proteins are arranged. The goal is to better understand differences between breast cancer subtypes. Participants provide samples during routine ca…

This study explores whether using alternative and complementary therapies, like turmeric supplements, affects how well early-stage breast cancer patients stick to their tamoxifen treatment. Researchers will follow 200 patients for one day to measure medication adherence and tamox…

This study looks at how the immune system responds to immunotherapy drugs in people with advanced solid cancers like lung, head and neck, melanoma, and bladder cancer. Researchers will collect tumor and blood samples to find biological markers that predict whether the treatment w…

This study collects blood and tumor samples from 80 people with newly diagnosed glioblastoma to find biological markers that predict how well the tumor responds to Tumor Treating Fields (TTFields). Participants receive standard treatment plus TTFields, and samples are taken befor…

This study looks at whether a score based on two common blood markers (CRP and albumin) can predict how well patients with advanced intestinal neuroendocrine tumors respond to a type of radiation therapy called Lu-177 oxodotreotide. Researchers will follow 150 patients for 36 mon…

This study looks at how radiation to the brain affects memory in children who had a brain tumor. Researchers will test memory and thinking skills in 130 children ages 4 to 12, starting 2 years after radiation and again 2 years later. The goal is to learn which parts of the brain …

This study looks at families who carry a change in the DDX41 gene, which may increase the risk of blood cancers. Researchers will track up to 910 people over time to see how many develop blood diseases and at what age. The goal is to create better guidelines for monitoring and co…

This study follows 600 people with epithelial ovarian cancer to find out why some tumors stop responding to platinum-based chemotherapy. Participants receive standard treatment and provide blood, tumor, and fluid samples over 5 years. No new drugs are tested; the goal is to colle…

This study looks at how body weight affects the amount of a breast cancer drug (Trastuzumab-Deruxtecan) in the blood and its side effects. Researchers will compare normal-weight and overweight/obese patients with advanced breast cancer. The goal is to see if weight changes drug e…

This study looks at whether a simple blood test can spot changes in the BRCA gene that might signal ovarian cancer is getting worse. Researchers will collect blood samples from 130 patients with BRCA-mutated ovarian cancer who are taking a maintenance drug called Olaparib (someti…

This study is collecting tumor and blood samples from 1,100 people with various cancers (head and neck, ovarian, cervical, lung, brain, and anal) to measure how active certain immune cells are. The goal is to better understand why some cancers trigger a stronger immune response t…

This study aims to understand why some breast cancers with BRCA1/2 mutations stop responding to PARP inhibitor drugs. Researchers will analyze tumor and blood samples from 120 people with advanced breast cancer to look for specific genetic markers linked to drug resistance. The g…

This study aims to better understand the immune system's role in rare soft tissue sarcomas. Researchers will collect medical information and tumor samples from 500 patients (400 new and 100 from past records) to analyze immune markers and genetic signatures. The goal is to learn …

This study looks at whether a blood test (liquid biopsy) can detect prostate cancer cells as well as a special PET scan. Researchers will compare results from 80 men with prostate cancer to see if the blood test matches the scan findings. The goal is to find a simpler way to moni…

This study follows 150 people with a GATA2 gene mutation to learn what early changes in blood and bone marrow might lead to serious blood cancers like leukemia. Researchers will collect blood and bone marrow samples during routine care over 5 years. No new treatments are being te…

This study compares three different blood tests (CellSearch, Parsortix, and SmartCatch) to see which one is best at finding circulating tumor cells in people with metastatic breast or prostate cancer. About 54 patients will give a blood sample before starting a new treatment. The…

This study looks back at data from 370 children and teens treated for ependymoma, a common brain tumor. Researchers want to understand why half of these tumors come back after surgery and radiation. They will use advanced imaging, genetics, and artificial intelligence to find pat…