Institut Claudius Regaud

This early-phase study tested whether adding an anti-TNF drug (infliximab or certolizumab) to standard immunotherapy (nivolumab and ipilimumab) could reduce severe side effects in people with advanced melanoma. The study enrolled 33 adults with metastatic or unresectable melanoma…

This study tested the drug sunitinib in 21 people with kidney cancer that had spread to the brain. The goal was to see if the drug could shrink brain tumors. Sunitinib works by blocking enzymes that help cancer cells grow and by cutting off blood flow to tumors. The trial was com…

This phase 2 study tested whether combining two chemotherapy drugs, gemcitabine and cisplatin, can shrink tumors in people with advanced or metastatic penile cancer. Fifty adults with inoperable or spread cancer took part. The main goal was to see how many patients responded to t…

This study tested a focused radiation therapy for men with low-risk prostate cancer. 18 men received a permanent radioactive implant only in the tumor area. The main goal was to see if the planned radiation dose could be delivered accurately. Results will help decide if this less…

This early-phase study tested a targeted radiation therapy (PRRT) in children whose neuroblastoma had come back or not responded to standard treatments. The therapy uses a radioactive drug that seeks out cancer cells. The main goal was to find the safest dose. Only one child took…

This study tested a breast cancer surgery called nipple-sparing mastectomy, where the breast tissue is removed but the nipple and skin are kept. 450 patients with early-stage breast cancer were followed for 5 years to see if the cancer came back in the nipple area. The goal was t…

This study tested a new treatment for glioblastoma, a fast-growing brain cancer that had come back after initial therapy. The treatment combined a precise, high-dose radiation technique with an immunotherapy drug called durvalumab, which helps the immune system attack cancer cell…

This study looked at whether a special PET scan tracer called F-DOPA can better find leftover cancer in lymph nodes after thyroid surgery compared to standard scans. Twenty-four adults with high levels of the tumor marker thyrocalcitonin after surgery took part. The goal was to s…

This study looked at how well two different PET-CT scanners can find very small cancer spots (less than 1 cm) in 24 cancer patients. Patients were grouped by body size, and each had two scans. The goal was to see which scanner detects more tiny lesions, which could help doctors c…

This study compared a capsaicin patch (Qutenza) to a standard nerve pain medication (amitriptyline) in 13 head and neck cancer survivors with long-term nerve pain. The goal was to see if the patch could reduce pain and improve quality of life. Participants received either the pat…

This study looked at whether tiny molecules called microRNAs in the blood can help predict if hormone therapy will work for women with advanced breast cancer. Researchers tested blood samples from 39 women before and after one month of treatment with tamoxifen or an aromatase inh…

This study aims to create a scoring system that helps doctors identify which patients with metastatic breast cancer are likely to live longer with a third round of chemotherapy. Researchers will track 267 women over several years, using standard tests and newer methods like count…

This study looked at how a person's genes and drug levels in the blood affect hormone therapy for breast cancer. It included 2000 women with hormone-sensitive breast cancer who were already scheduled for adjuvant hormone therapy. Researchers measured drug levels and genetic marke…

This study followed 150 patients with solid tumors who were starting immunotherapy to see how side effects develop over time. Researchers collected data on side effects and patient quality of life during routine treatment. The goal was to better understand and predict these side …

This study looked at whether it's possible to measure certain substances called oxysterols in the blood of breast cancer patients. 29 women taking hormonal therapy (tamoxifen or anti-aromatase drugs) had their blood tested before and 28 days after starting treatment. The goal was…

This study looked at whether adjusting the dose of two common kidney cancer drugs (sunitinib and pazopanib) based on their levels in the blood can improve treatment outcomes. It involved 47 patients with advanced or metastatic kidney cancer. The goal was to see if this personaliz…

This study looked at men who had breast cancer to find possible causes beyond genetics. Researchers collected information about their life, work, and family background using a 75-question survey. The goal was to describe these factors, not to test a treatment. About 93 men took p…

This study involved 60 people with advanced melanoma who were already scheduled to receive immunotherapy drugs (either a single drug or a combination). Researchers collected blood samples and, when possible, tumor samples before and during treatment to look for markers that might…

This study looked at whether following national guidelines for ovarian cancer surgery is cost-effective. Researchers measured the cost per quality-adjusted life year (QALY) over three years in 200 women with advanced ovarian cancer. The goal was to understand the economic impact …

This study looked at 60 people with diffuse large B-cell lymphoma who were starting standard chemotherapy (R-CHOP). Researchers used advanced single-cell technology to analyze tumor and blood samples over two years. The goal was to find biomarkers that could help predict how well…

This study looked at 60 people with metastatic breast cancer to find out whether certain cells in their blood (called DP-circulating cells) come from the tumor. Researchers took a blood sample before starting treatment and checked tumor samples. The goal was to better understand …

This study tested whether a special 'return home' consultation between the patient, their family doctor, and a specialist could reduce unplanned hospital visits for people with metastatic cancer. Over 600 patients were randomly assigned to either standard care or this organized c…

This study looked at how the anti-nausea medication aprepitant changes the levels of the chemotherapy drug ifosfamide in the blood of people with soft tissue sarcoma. Fifty-nine patients receiving standard chemotherapy (doxorubicin and ifosfamide) were followed for two treatment …

This study looked at whether the body's internal clock (circadian rhythm) affects how cancer cells travel in the blood of people with advanced lung cancer. Researchers took blood samples from 27 patients before they started cancer treatment. The goal was to see if the number of c…