Institut Claudius Regaud

This study tested a precise radiation implant (brachytherapy) for men with low-risk prostate cancer. Instead of treating the whole prostate, doctors placed radioactive seeds only in the tumor area. The goal was to see if this targeted approach could deliver the right radiation do…

This study looked at whether measuring drug levels in the blood and adjusting doses accordingly can improve treatment for advanced kidney cancer. About 47 patients taking sunitinib or pazopanib were followed to see if this approach reduced side effects and kept the cancer from gr…

This phase 2 trial tested a high-dose chemotherapy regimen called TICE in 101 patients with germ cell tumors that had relapsed or were not responding to standard treatment. The approach uses two cycles of paclitaxel and ifosfamide followed by three cycles of carboplatin and etopo…

This early-phase study tested a type of radiation therapy called PRRT in children whose neuroblastoma had come back or did not respond to standard treatments. The goal was to find the safest dose of the radioactive drug 177Lu-DOTATATE. Only one child took part, and the study focu…

This early-phase study tested whether adding a TNF-blocking drug (infliximab or certolizumab) to standard immunotherapy (nivolumab and ipilimumab) is safe for people with advanced melanoma that has spread. The main goal was to find the best dose and check for serious side effects…

This study tested whether a combination of two chemotherapy drugs, gemcitabine and cisplatin, can shrink tumors in people with advanced or metastatic penile cancer. Fifty adults with inoperable or spreading disease took part. The main goal was to see how many patients responded t…

This study tested a type of breast cancer surgery called nipple-sparing mastectomy, where the breast tissue is removed but the nipple and skin are kept. It involved 450 women with early-stage breast cancer who needed a full mastectomy. The goal was to see if this surgery keeps th…

This study tested the drug sunitinib in 21 people with kidney cancer that had spread to the brain. The goal was to see if the drug could shrink brain tumors. Sunitinib works by blocking enzymes that help cancer cells grow and by cutting off blood flow to tumors. The trial was com…

This study tested a new treatment for glioblastoma, a fast-growing brain cancer that had come back after initial therapy. The treatment combined a precise, high-dose radiation technique with an immunotherapy drug called durvalumab, which helps the immune system attack cancer cell…

This study tested a special radioactive tracer called 18F-DOPA for PET scans in 24 patients with medullary thyroid cancer who had high levels of a tumor marker after surgery. The goal was to see if this new scan could find remaining cancer in lymph nodes better than standard imag…

This study compared a capsaicin patch (Qutenza) to a standard nerve pain medication (amitriptyline) in 13 head and neck cancer survivors with long-term nerve pain. The goal was to see if the patch could reduce pain and improve quality of life. Participants received either the pat…

This study looked at whether the time of day affects the number of cancer cells floating in the blood of people with advanced lung cancer. Researchers took blood samples from 27 patients at 4 a.m. and 10 a.m. before starting treatment. The goal was to see if circadian rhythms inf…

This study aims to create a score that helps doctors identify which patients with metastatic breast cancer are likely to live longer with a third line of chemotherapy. Researchers will collect clinical, histological, and biological data from 267 women starting third-line treatmen…

This study followed 150 people with solid tumors who were starting immunotherapy (immune checkpoint inhibitors) as part of their regular care. Researchers collected data on side effects and asked patients to fill out questionnaires before each treatment. The goal was to better un…

This study tested two different PET-CT scanners to see which one is better at finding very small cancer spots (less than 1 cm) in patients. Twenty-four people with cancer each had two scans, one on each machine. The researchers then added virtual lesions to the images to compare …

This study collected information from 93 men who have had breast cancer. Participants filled out a questionnaire about their life, work, family, and health history. The goal is to find patterns that might help explain why some men develop breast cancer. No treatments or drugs wer…

This study looked at whether a special meeting between a cancer patient, their hospital doctor, and their regular family doctor before leaving the hospital could help reduce unplanned trips back to the hospital. About 667 adults with metastatic cancer took part. Half got the usua…

This study involved 60 people with advanced melanoma who were already scheduled to receive immunotherapy drugs. Researchers collected blood samples and, when possible, tumor samples before and during treatment to look for markers that might predict whether the cancer would shrink…

This study looked at whether tiny molecules called microRNAs in the blood can help predict if hormone therapy will work for women with advanced breast cancer. Researchers tested blood samples from 39 women before and after one month of treatment with tamoxifen or an aromatase inh…

This study looked at how a person's genes and drug levels in the blood affect hormone therapy for breast cancer. It included 2000 women with hormone-sensitive breast cancer who were already scheduled for adjuvant hormone therapy. Researchers measured drug levels and genetic marke…

This study looked at whether it's possible to measure certain substances called oxysterols in the blood of breast cancer patients. 29 women taking hormonal therapy (tamoxifen or anti-aromatase drugs) had their blood tested before and 28 days after starting treatment. The goal was…

This study looked at whether following national guidelines for ovarian cancer surgery is cost-effective. Researchers measured the cost per quality-adjusted life year (QALY) over three years in 200 women with advanced ovarian cancer. The goal was to understand the economic impact …

This study looked at 60 people with diffuse large B-cell lymphoma who were starting standard chemotherapy (R-CHOP). Researchers used advanced single-cell technology to analyze tumor and blood samples over two years. The goal was to find biomarkers that could help predict how well…

This study looked at 60 people with metastatic breast cancer to find out whether certain cells in their blood (called DP-circulating cells) come from the tumor. Researchers took a blood sample before starting treatment and checked tumor samples. The goal was to better understand …

This study looked at how the anti-nausea medication aprepitant changes the levels of the chemotherapy drug ifosfamide in the blood of people with soft tissue sarcoma. Fifty-nine patients receiving standard chemotherapy (doxorubicin and ifosfamide) were followed for two treatment …