Icahn School Of Medicine At Mount Sinai

This study tests two treatments for people with repeat C. diff infections: a lab-made bacteria mix called MTC01 and a fecal transplant (FMT) from a healthy donor. Both are given during a colonoscopy. The goal is to see which is safer and better at stopping the infection from comi…

This pilot study is testing whether a rapid, timed sequence of different drugs can improve outcomes for people with advanced or inoperable clear cell kidney cancer. Participants first receive cabozantinib, then a combination of two immunotherapies (ipilimumab and nivolumab), foll…

This trial uses brain scans to see whether 8 weeks of mindfulness-based group therapy changes how the brain processes reward, craving, and self-control in people with heroin addiction. About 157 adults on medication for opioid use disorder will be randomly assigned to mindfulness…

This early-phase trial tested a combination of four therapies to see if they could safely boost the immune system to fight cancer. 17 adults with non-Hodgkin's lymphoma, metastatic breast cancer, or head & neck cancer received low-dose radiation and two immune-boosting drugs inje…

This study tested whether adding an experimental drug (CCR2/5-inhibitor or anti-IL-8) to the immunotherapy nivolumab before and after surgery could help shrink tumors and improve long-term survival in people with non-small cell lung cancer or liver cancer. 48 participants receive…

This study looked at whether changing antipsychotic medication can better control schizophrenia symptoms in people already taking these drugs. Researchers followed 219 adults with schizophrenia or schizoaffective disorder who still had symptoms despite treatment. The main measure…

This study tested whether the diabetes drug ertugliflozin can reduce fluid buildup in the skin and tissues of people with heart failure. 28 adults with reduced heart function took the drug or a placebo for one month each. Researchers measured skin water and sodium content to see …

This study tested whether nintedanib, a drug used for other lung diseases, can slow down lung damage in people who had severe COVID-19. It included 103 adults who still had lung problems more than 30 days after their COVID diagnosis. The main goal was to see if the drug helped ma…

This study tested a drug called bimekizumab in 60 adults with moderate-to-severe plaque psoriasis who had not improved with other similar treatments. The drug works by blocking certain inflammatory substances in the body to reduce skin redness, scaling, and thickness. The main go…

This study tested a shorter radiation schedule (3 weeks instead of 6-7) for head and neck cancer in people aged 70 and older. The goal was to see if it could still control the cancer while reducing side effects and treatment gaps. 37 participants received either adjuvant or defin…

This study tested a phone-based coaching program to help teenagers who had a liver transplant take their anti-rejection medication regularly. The program used personalized calls to improve adherence, with the goal of reducing organ rejection. A total of 148 teens aged 12 to 20 wh…

This pilot study tested whether offering HIV prevention medication (PrEP) in the emergency department is feasible. 26 adults at high risk for HIV were enrolled. The goal was to see if people would start PrEP and follow up with a clinic within 30 days. The study aimed to overcome …

This study tests whether a small device worn on the ear, which gently stimulates a nerve linked to the body's calming system, can improve conditions during sinus surgery. Half of the participants will receive the active stimulation, while the other half gets a sham device. Resear…

This study compares two common labor-inducing drugs, misoprostol and pitocin, in 300 pregnant people with a BMI of 30 or higher. Both drugs are given along with a balloon catheter. The goal is to see which drug leads to a faster delivery and whether it increases the chance of a v…

This trial tests whether a tailored lighting intervention, controlled by a wireless device, can improve sleep and mood in people with Alzheimer's disease. Participants receive either active lighting designed to affect the body's internal clock or a control lighting with no intend…

This trial investigates whether daily exposure to a bluish-white light (at least 300-500 lux for two hours) can improve sleep efficiency, reduce depression, and calm agitation in people with mild to moderate Alzheimer's or related dementias. Participants are assigned to one of th…

This study tested whether a tailored light intervention could improve thinking, sleep, and metabolism in 25 people with mild cognitive impairment or mild Alzheimer's disease. Participants received either active or placebo lighting at home. The goal was to see if light exposure co…

This trial investigates whether a transcutaneous electrical nerve stimulation (TENS) device can reduce pain during IUD insertion. About 99 women receiving an IUD will be randomly assigned to either an active TENS unit or a placebo device. Participants will rate their pain on a sc…

This study tests whether a special flickering light (40 Hz) can improve sleep and thinking in people with mild cognitive impairment or early Alzheimer's disease. Participants will sit under the light for one hour while researchers measure brain activity and memory. The goal is to…

This study tested two drugs, epinephrine and dexmedetomidine, added to standard spinal anesthesia for planned C-sections. 90 pregnant women participated to see which drug provides longer pain relief and faster recovery of movement. The goal is to improve comfort and shorten recov…

This study looked at whether a recreational ballet program called Ballet for all Kids can help children with autism spectrum disorder (ASD) improve their motor skills. 32 children aged 6-12 with ASD participated in the program for 12 weeks. Researchers measured changes in coordin…

This study looked at whether different lengths of light exposure can improve sleep, mood, and agitation in people with Alzheimer's disease. 135 participants were randomly assigned to receive 2 hours, 4 hours, or all-day morning light. The goal was to see which light schedule work…

This study tested whether a special type of lighting, called a tailored lighting intervention, could help people with mild to moderate Alzheimer's disease and type 2 diabetes sleep better and improve their metabolism. Sixty-one participants living in assisted living or nursing ho…

This study tested whether a long-term light treatment could improve sleep and memory in 73 people with mild cognitive impairment or mild Alzheimer's disease living at home. Participants used a special light device, and researchers measured changes in thinking skills and sleep qua…

This study tested whether a special light therapy, used for 6 months, could improve sleep, mood, thinking, and daily behavior in 100 people with Alzheimer's disease or mild cognitive impairment. Participants either received the active light treatment or a placebo light. The goal …

This study tested whether a low-level magnetic therapy device, used at home, is safe and practical for people with Long COVID who have memory and thinking problems. Thirty adults with persistent cognitive issues after COVID-19 used the device daily for 4 weeks, then were followed…

This study tested whether daily singing of personally meaningful songs can boost memory and language in people with Alzheimer's disease or mild cognitive impairment. One hundred participants worked with a music therapist and sang a 'song of kin' at home for 12 months. Researchers…

This study tested two types of pain-relief injections (liposomal bupivacaine vs. standard bupivacaine) given during open fibroid surgery. 140 women participated to see which method reduced the need for opioid painkillers after the operation. The goal was to improve pain control a…

This study tested a device called the Sana Pain Reliever for people with long-term nerve pain. 75 adults used the device at home for 8 to 14 weeks. Researchers measured changes in pain symptoms using a standard pain scale. The goal was to see if the device could help reduce pain …

This study looked at whether music therapy sessions could help people with depression feel better and become more resilient. 84 participants aged 8 to 70 with depression took part in weekly music therapy or wellness concerts for three months. Researchers measured changes in depre…

This pilot study is testing whether a noninvasive ultrasound device, called USCOM, can measure how well the heart is pumping blood in pregnant people who have just been diagnosed with fetal growth restriction (FGR). FGR means the baby is smaller than expected, and this condition …

This observational study is looking at over 1,000 adults with asthma to better understand different types of the disease. Researchers will combine real-world medical records with genetic data to see how patients respond to various treatments. The goal is to identify asthma subtyp…

This study looks at how damage to the vagus nerve may cause gut issues and inflammation in people with HIV. Researchers will test two approaches—a drug called pyridostigmine and non-invasive vagus nerve stimulation—to see if they can improve gut function and reduce inflammation. …

This study will analyze the genetic makeup of tumors from 100 people with relapsed multiple myeloma. Researchers will use advanced DNA and RNA sequencing to find genetic changes and understand how the cancer works. The goal is to gather information that could guide more personali…

This study tested whether rhythmic light therapy can improve brain activity and memory in 20 people with mild cognitive impairment. Participants sat through three one-hour sessions with different light patterns while their brain waves were recorded. The goal was to see if certain…

This study looked at pressure inside the kidney during surgery to remove kidney stones. Twenty-one adults had the procedure with either a suction or a non-suction tube. The goal was to see which method keeps pressure lower, which could make surgery safer and help clear more stone…

This completed study looked at ways to increase diversity in cancer clinical trials, focusing on breast, liver, and prostate cancers. Researchers worked with communities, doctors, and scientists in New York City to find better ways to include people of color and underserved group…

This completed study tested whether sotagliflozin, a dual SGLT1/2 inhibitor, reduces blood clot formation better than empagliflozin, a standard SGLT2 inhibitor. Seventeen healthy volunteers took each drug for one month in a crossover design. Researchers measured clot size and pla…

This completed study involved 93 adults with stage 4 incurable bladder cancer. Participants completed surveys and focus groups to identify their supportive care and educational needs. The goal was to design a screening tool to help healthcare teams better address these needs in t…

This study tested a new online tool called the Personal Patient Profile for Bladder Cancer (P3BC) in 24 patients who were facing bladder removal surgery. The tool provides personalized information, videos, and summaries to help patients talk with their doctors and prepare for rec…

This completed study looked at 108 adults having surgery for kidney stones. It compared a balloon-tipped catheter to a standard small tube to see which one better prevents stone fragments from moving into the ureter. The goal is to help surgeons choose the best tool for the job.

This study looked at 15 people with a rare genetic condition called DDX3X syndrome, which can cause intellectual disability and sometimes autism. Researchers used interviews, play-based assessments, and genetic tests to better understand the condition. The goal was to describe th…

This study measured the amount of xylazine—a dangerous animal sedative often mixed with opioids—in the blood and urine of 75 emergency room patients who had a non-fatal opioid overdose. The goal was to see how common xylazine is and how well test strips can detect it. The finding…

This study looked at how eating and fasting affect self-control in women with and without bulimia nervosa. Researchers used brain scans and computer tasks to see differences in behavior and brain activity. The goal was to better understand what drives bulimia symptoms. 100 adult …

This study looked at 104 patients to find the optimal number of tissue samples (biopsies) to take during a pleuroscopy, a procedure to examine the lining of the lungs. The goal was to see how many biopsies are needed to make a diagnosis and to get enough tissue for further testin…

This small study tested whether a special light program on an iPad can suppress melatonin, a hormone that helps control sleep. Ten healthy adults over 30 used the Circadian OS software, and researchers measured their melatonin levels and sleepiness. The goal was to see if this te…

This study tested a new brain-training method to help people with heroin addiction reduce cravings. Participants watched drug-related videos while getting real-time feedback on their brain activity, learning to match the brain patterns of people further along in recovery. The goa…

This study looked at heart and lung function in 106 people with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) to better understand post-exertional malaise—the severe worsening of symptoms after physical activity. Participants did two maximal exercise tests on consec…

This study looked at whether text message reminders help people over 55 with normal thinking skills follow a daily morning light routine. The light is meant to help reset the body's internal clock. Twenty healthy adults took part, and researchers measured their light exposure and…

This completed Phase 1 trial looked at how cannabidiol (CBD) is absorbed and processed in 24 healthy adults. Researchers gave different doses of CBD and measured its levels in blood and urine, along with any side effects. The goal was to understand the drug's pharmacokinetics, no…

This study tested a web-based app called STOMA Care to see if it is practical and helpful for bladder or colorectal cancer patients getting ostomy surgery and their family caregivers. Researchers measured how well the app worked by tracking recruitment, retention, and changes in …

This completed study at Mount Sinai measured brain waves and other body signals in 50 healthy volunteers during a standard hypnosis session. The goal was to collect data to train an artificial intelligence tool that can recognize when a person is calm or in a trance. Future resea…

This completed study looked at over 9,400 patients who had liver surgery to see if a minimally invasive approach (using small incisions) leads to fewer complications than traditional open surgery. Researchers tracked deaths, infections, readmissions, and repeat surgeries within 3…