Fred Hutchinson Cancer Center

This phase 2 trial tests whether the drug vorinostat can increase the amount of a target (PSMA) on prostate cancer cells, making them more visible to a radioactive therapy called 177Lu-PSMA-617. The study enrolls 15 men with PSMA-low metastatic castration-resistant prostate cance…

This early-phase trial is testing whether a personalized vaccine made from each patient's unique tumor proteins can safely boost the immune system against advanced breast cancer, melanoma, and lung cancer. The vaccine is given along with an immune-boosting drug (nivolumab) and an…

This study tests whether a program that includes a patient navigator, an educational video about colonoscopy, and a free rideshare ride home can help more people complete a follow-up colonoscopy after an abnormal stool-based colorectal cancer screening test. About 682 adults aged…

This study tests whether the drug belumosudil can prevent chronic graft-versus-host disease (cGVHD) from worsening in stem cell transplant recipients. About 82 participants will receive either belumosudil or a placebo. The goal is to see if the drug delays the need for additional…

This early-stage trial tests a new type of immunotherapy called CAR T-cells, which are made from a patient's own immune cells and engineered to attack cancer cells that carry a protein called FOLR1. The study enrolls up to 30 people aged 1 to 75 with advanced osteosarcoma that ha…

This phase 1 trial tests giving a powerful chemotherapy combination (CLAG-M or FLAG-Ida) immediately followed by a reduced-intensity stem cell transplant for adults with myeloid cancers that have come back or not responded to treatment. The goal is to find the best dose of total …

This phase 2 trial tests whether remdesivir, an antiviral drug, can safely treat RSV infections in the upper respiratory tract of patients whose immune systems are suppressed by cellular or bispecific antibody therapies. RSV can cause severe pneumonia in these patients. The study…

This phase 2 trial tests whether adding the drug ruxolitinib to standard care can prevent graft-versus-host disease (GVHD) in older patients with myelofibrosis or MDS/MPN overlap syndromes who receive a donor stem cell transplant. About 50 participants will get ruxolitinib before…

This study is for people with high-risk acute leukemias or myelodysplastic syndrome. It tests a radioactive antibody that targets cancer cells before a donor stem cell transplant. The goal is to find the safest and most effective dose. About 75 adults will take part.

This early-stage study tests whether giving patients a fecal transplant (donated stool) along with extra dietary fiber can help treat gut graft versus host disease, a serious complication after a stem cell transplant. About 72 adults who had a stem cell transplant in the past yea…

This study tests whether giving antibody replacement therapy can reduce serious infections in people who have received CAR-T cell therapy for blood cancers. CAR-T therapy often lowers the body's natural antibodies, raising infection risk. The trial will compare the antibody treat…

This study tests a new treatment plan for adults aged 60 and older with aggressive acute myeloid leukemia (AML) or similar blood cancers. Participants receive strong chemotherapy (FLAG-Ida) followed just days later by a lower-dose radiation and a donor stem cell transplant. The g…

This study tests a less intense chemotherapy combination (treosulfan, fludarabine, and thiotepa) given before a donor stem cell transplant for people with non-cancerous blood or immune system disorders. The goal is to see if this gentler regimen can still allow the donor cells to…

This study tests whether adding a targeted drug (nemtabrutinib) to a personalized cell therapy (lisocabtagene maraleucel) can help people with chronic lymphocytic leukemia or small lymphocytic lymphoma that has returned or stopped responding to treatment. About 20 adults will rec…

This study tests a faster, hospital-based dose increase of the drug sonrotoclax for people with chronic lymphocytic leukemia (CLL), small lymphocytic lymphoma (SLL), or mantle cell lymphoma (MCL) that is new, has returned, or hasn't responded to treatment. Participants first rece…

This study tests a new approach to prepare patients with non-cancer blood diseases for a donor stem cell transplant. Instead of high-dose total body radiation, patients receive a radioactive antibody that targets blood-forming cells, aiming to reduce rejection and side effects. T…

This study compares a new smartphone app called IndigeQuit to an existing app (NCI QuitGuide) to help American Indian and Alaska Native adults quit smoking. About 776 participants who smoke daily and want to quit within 30 days will be randomly assigned to use one of the apps. Th…

This early-phase trial tests a new type of immunotherapy for children and adults whose acute leukemia has come back or not responded after a donor stem cell transplant. The treatment uses specially engineered donor immune cells (T cells) that are designed to recognize and attack …

This study tests whether removing a specific type of immune cell (naive T cells) from donor stem cells can prevent chronic graft-versus-host disease (GVHD) in children and young adults with blood cancers. GVHD occurs when donor cells attack the patient's body after a stem cell tr…

This study is for people with myelofibrosis, a type of bone marrow cancer. It tests whether giving a JAK inhibitor drug before, during, and after a half-matched stem cell transplant can lower the risk of graft-versus-host disease (a common complication where donor cells attack th…

This study tests whether adding an experimental drug (ST-067) to standard CAR T-cell therapy can safely and effectively treat adults with large B-cell lymphoma that has returned or not responded to prior treatments. About 33 participants will receive the combination to see if it …

This study tests a new combination of two drugs (pralatrexate and bendamustine) plus low-dose total-body radiation before a donor stem cell transplant for people with T-cell lymphoma that has come back or not responded to treatment. The goal is to see if this approach is safe and…

This early-stage trial tests a drug called DR-18 in 20 adults whose leukemia (AML) or related bone marrow disease (MDS) has come back or persists after a stem cell transplant. DR-18 is designed to boost the body's immune cells to fight the cancer. The main goals are to find the s…

This study tests two remote weight loss programs designed for Latina breast cancer survivors. Being overweight can worsen breast cancer outcomes, and few programs exist for this group. The study will enroll 640 women who have had breast cancer to see which approach works best for…

This study tests a radioactive antibody (211At-BC8-B10) that seeks out and attacks cancer cells, followed by a donor stem cell transplant for people with high-risk leukemia or myelodysplastic syndrome (MDS) that has returned or not responded to treatment. The goal is to find the …

This study tests a special cord blood transplant for people with high-risk blood cancers like leukemia and lymphoma. Participants get chemotherapy and radiation before the transplant to kill cancer cells and prepare the body. After the transplant, drugs are given to prevent the n…

This study looks at whether high-intensity exercise and a high-fiber diet are practical and helpful for people with advanced melanoma who are receiving immunotherapy. About 40 adults will be assigned to exercise, diet changes, both, or standard care. The goal is to see if these l…

This study tests a drug called axatilimab for people whose skin becomes thick and hard (sclerotic) after a donor stem cell transplant, a condition called chronic graft-versus-host disease. The drug aims to block immune signals that cause inflammation and scarring. About 50 adults…

This study tests a stem cell transplant from half-matched (haploidentical) donors for people with various blood cancers. Before the transplant, patients receive chemotherapy and low-dose radiation to prepare their body. The goal is to replace diseased bone marrow with healthy don…

This study tests a new approach for adults with aggressive blood cancers (like AML) that are likely to return after standard treatment. Participants receive a combination of chemotherapy drugs (decitabine plus FLAG-Ida) and low-dose radiation, followed immediately by a stem cell …

This study tests whether reducing the dose of the drug linvoseltamab, based on how well a patient responds early on, is safe and effective for people with multiple myeloma that has returned or stopped responding to other treatments. The goal is to keep the cancer under control wh…

This study tests two different methods to lower the risk of graft-versus-host disease (GVHD), a serious complication where donor cells attack the patient's body, after a stem cell transplant. About 120 adults with acute leukemia or myelodysplastic syndrome (MDS) in remission will…

This study tests a combination of two drugs, acalabrutinib and venetoclax, in people whose chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL) has returned or stopped responding to treatment. The goal is to see if the combo can kill more cancer cells and achiev…

This early-stage trial tests a new treatment called FOLR1 CAR T for children aged 6 or younger with a type of leukemia (AML) that has returned or not responded to standard therapy. The treatment involves taking a child's own immune cells, modifying them in a lab to recognize and …

This early-phase trial tests a personalized treatment for people with metastatic solid tumors that have a specific genetic change called KRAS G12V. The patient's own immune cells (T cells) are collected, genetically modified to recognize and attack cancer cells carrying the KRAS …

This study tests a new treatment for men with advanced prostate cancer that has spread and no longer responds to standard hormone therapy. The treatment uses the patient's own immune cells, modified in a lab to better recognize and attack prostate cancer cells, combined with a ho…

This study tests whether the antibiotic rifaximin can reduce abnormal proteins in people with a precancerous blood condition called IgA MGUS. About 50 adults will either receive the drug or no treatment. The goal is to see if rifaximin can lower the risk of progression to multipl…

This study tests whether a dental cleaning shortly after a stem cell transplant can prevent chronic graft-versus-host disease (GVHD), a common and serious complication. Researchers will enroll 45 adults receiving a donor stem cell transplant for blood cancer. The goal is to see i…

This study compares two versions of a smartphone app called Living Free from Tobacco (LiFT) to help young adults ages 18-30 quit using nicotine and tobacco products. About 140 participants will use one of two app versions: one focuses on building mental flexibility to support qui…

This study tests whether limiting eating to an 8-hour window each day (time-restricted eating) can improve how well cancer treatments work and reduce side effects. It enrolls 100 Alaska Native or American Indian adults with rectal or breast cancer who are about to start treatment…

This study tests a smartphone app called ACT on Vaping to help young adults (ages 18-30) quit using e-cigarettes. The app uses behavioral therapy to help users recognize triggers and build skills to stop vaping. About 1,178 participants will use the app or a control, and research…

This study tests whether a specific type of exercise—aerobic interval training—can boost the immune system and improve how well immunotherapy works in people with non-small cell lung cancer. About 100 participants who are already on immunotherapy will either exercise or not, and …

This study tests whether a telephone coaching program called Talking About Cancer (TAC) helps people with advanced cancer and their support person engage in advance care planning, such as having end-of-life conversations and completing advance directives. About 80 patients and th…

This study looks at whether it's possible for people getting donor stem cell transplants to take extra fiber by mouth or feeding tube. The goal is to see if patients can tolerate the fiber and if it helps support nutrition and gut health. About 40 adults will be enrolled, and res…

This study tests a cooking and nutrition program for 80 adults in southern New Mexico. The goal is to see if teaching healthy cooking techniques can improve diet quality and knowledge about cancer prevention. Participants will attend 6 in-person classes and complete surveys. The …

This study collects blood samples and health data from 300 adults with chronic graft-versus-host disease (cGVHD) who are starting a new treatment. The goal is to find changes in the blood that can predict how well a treatment will work. This is an observational study, not a test …

This study follows 250 people who have had a donor stem cell transplant to see if respiratory viruses trigger a lung condition called bronchiolitis obliterans syndrome (BOS). Participants use a simple handheld device at home to check their lung function regularly. The goal is to …

This study tests a mobile app called PACT that helps people with advanced cancer talk about and plan the medical care they would want if they couldn't speak for themselves. About 400 patients and their chosen support persons will use the app and report on how easy and helpful it …

This study looks at how to help people in Zimbabwe who have both cancer and HIV stay engaged in their HIV care while they are being treated for cancer. Researchers will first observe 150 patients to understand the barriers they face, then develop and test strategies to make it ea…

This study looks at whether moderate-to-vigorous exercise can change the gut bacteria of people who have had stage II or III colorectal cancer. Researchers want to see if these changes might help improve cancer outcomes. The study involves 30 survivors and focuses on whether the …

This study aims to create simple screening tools to identify financial hardship in people with Alzheimer's and their caregivers. Researchers will interview patients and caregivers, then survey large groups to develop and test the measures. The goal is to help healthcare providers…

This study looks at whether patient navigation services, an interactive website, or both can help people who had stage I-III colorectal cancer get the recommended follow-up tests after surgery. About 75 survivors will be assigned to one of three groups to see which approach works…

This study looks at whether adults with acute myeloid leukemia (AML) who are not healthy enough for strong chemotherapy are willing to let a computer randomly assign them to either lower- or higher-intensity treatment. The goal is to see if this approach is acceptable to patients…

This study looks at whether a patient navigator or a website called PACT can help people who had a stem cell transplant for blood cancer plan their future medical care. About 40 adults who are 1 to 5 years post-transplant will be enrolled. The goal is to see if these tools help p…

This study tests a workshop called HOPE-C, designed to reduce burnout among doctors, nurses, and social workers who care for ovarian cancer patients. The workshop helps clinicians share their challenging stories and build peer support. Researchers will enroll 25 participants to s…