Fred Hutchinson Cancer Center

This phase 2 trial tested whether anakinra, a drug normally used for rheumatoid arthritis, can prevent two serious side effects of CAR-T cell therapy: cytokine release syndrome (CRS) and nerve damage. The study enrolled 27 adults with B-cell non-Hodgkin lymphoma who were receivin…

This phase 2 trial tested a combination of treosulfan, fludarabine, and rabbit antithymocyte globulin before a bone marrow transplant in 40 people with bone marrow failure diseases like Diamond-Blackfan anemia and Shwachman-Diamond syndrome. The goal was to see if this conditioni…

This study tested whether removing a specific type of immune cell (naïve T cells) from donor stem cell grafts could prevent graft-versus-host disease (GVHD) after a stem cell transplant for blood cancers. The trial enrolled 84 patients who received high- or medium-intensity chemo…

This pilot study tested whether a diet and exercise program could prevent or reduce metabolic side effects like insulin resistance and weight gain in 20 men with prostate cancer receiving hormone therapy and radiation. Participants followed dietary instructions and did aerobic an…

This study looked at whether giving a JAK inhibitor drug before a donor stem cell transplant helps people with myelofibrosis, a serious bone marrow disorder. The goal was to reduce symptoms like an enlarged spleen and improve survival after transplant. 61 patients took part in th…

This study tested different drug combinations to prevent graft-versus-host disease (GVHD) in 174 people with blood cancers receiving stem cells from an unrelated donor. GVHD is a serious side effect where donor cells attack the patient's body. The goal was to find which drug regi…

This study tested a digital chatbot called QuitBot to see if it could help people stop smoking. Over 1,600 adult smokers who wanted to quit were randomly assigned to use QuitBot or another program. The main goal was to see how many people had not smoked for at least 30 days after…

This study tested whether giving two drugs—ixazomib and lenalidomide—in an alternating schedule after a stem cell transplant could safely delay the return of multiple myeloma. Thirty patients who had already received a transplant took part. The main goal was to check for side eff…

This study tested whether a home-based physical activity program, delivered by mail and phone without in-person visits, could help nearly 50,000 older women prevent heart attacks, strokes, broken hips, and falls. Participants received exercise guides, tips, and goal-setting tools…

This study tested different ways to provide HIV prevention medication (PrEP) through local pharmacies in Kenya. Over 5,800 people participated across 60 pharmacies. The goal was to see if offering PrEP directly at pharmacies, instead of referring people to clinics, helps more peo…

This study tested a new way to help young women in Kenya start PrEP, a daily pill that prevents HIV. Young women already taking PrEP were trained to refer their friends and give them HIV self-test kits. The goal was to see if this peer-led approach could increase PrEP use among t…

This study tested a smartphone app designed to help teen and young adult cancer survivors manage anxiety. The app uses attention bias modification (ABM) to retrain the brain to focus away from threats and toward positive or neutral cues, plus gratitude exercises. Researchers enro…

This study looked at whether following a healthy diet based on the Alternative Healthy Eating Index (AHEI) for 12 weeks could reduce pain and improve quality of life in women with endometriosis. 109 women with confirmed endometriosis and significant pain took part. Researchers me…

This pilot study looked at whether providing plant-based, whole-food meals to multiple myeloma patients during stem cell transplant is practical and well-tolerated. The goal was to see if this diet could help maintain healthy gut bacteria, which is often damaged during treatment.…

This completed study tested a program called INSPIRE-AYA for adolescent and young adult cancer survivors. The program used a mobile app, telehealth support, and educational materials to help survivors access healthcare resources and manage their health. Researchers measured chang…

This study followed 267 adults who had stem cell transplants to understand why some develop chronic graft-versus-host disease (GVHD), a common complication. Researchers collected blood, saliva, tears, and tissue samples, along with eye scans and breathing tests, to find early sig…

This study gave a rabies vaccine to people who had CAR-T therapy for B-cell cancers, plus healthy volunteers for comparison. The goal was to see how well the immune system responds to vaccination after CAR-T treatment. Researchers measured antibody levels to gauge immune function…

This study looked at whether telehealth education and care plans created by patients themselves can help cancer survivors living in rural areas. About 261 people who finished treatment for breast, colorectal, lung, prostate cancer, or lymphoma took part. The goal was to see if th…

This study tested a simple checklist tool to help people with sarcoma think about and plan for their future mobility needs, like getting around the house or dressing. 27 patients and their caregivers used the checklist after limb-saving or amputation surgery. The goal was to see …

This completed pilot study tested a program called GUIDE, which assigns a trained navigator to help cancer patients overcome social and financial barriers to joining clinical trials. The study included 100 adults with cancer who were already eligible for a trial but had at least …

This study tested a website designed to help people with advanced cancer plan for end-of-life care, including medical wishes, legal documents, and financial tasks. About 100 patients took part to see if the tool reduced distress and improved planning. The goal was to learn whethe…

This study tested a program called PLAN that helps Latino cancer patients understand and talk about the medical care they would want if they couldn't speak for themselves. 27 patients with advanced cancer took part. The goal was to see if the program was helpful and improved thei…

This study tested a new method to evaluate tuberculosis (TB) drugs and vaccines in 20 healthy adults. Researchers used a harmless version of the TB bacteria (BCG) to see how the body fights it and how treatments work. The goal was to create a faster, safer way to test new TB trea…