Fred Hutchinson Cancer Center

This study tests a new COVID-19 vaccine (LUNAR-COV19) in 56 adults who received a blood stem cell transplant within the past year. These patients often have weaker immune responses to standard vaccines. The new vaccine uses a self-amplifying mRNA that may produce a stronger and l…

This early-phase trial tests a new approach for people with high-risk multiple myeloma, including newly diagnosed or returning cancer. It combines a radioactive antibody that targets cancer cells, chemotherapy, and total-body radiation before a donor stem cell transplant. The goa…

This study compares two smartphone apps designed to help people stop smoking. One app uses a therapy that focuses on mood and behavior, while the other uses standard quitting advice. About 1,800 adult smokers who want to quit in the next month will use one of the apps for 30 days…

This study is testing two remote programs—a chatbot app called QuitBot and a text messaging service—to help American Indian and Alaska Native adults quit smoking. About 772 participants will be randomly assigned to one of the programs. The goal is to see which approach works bett…

This phase III trial will enroll 854 Hispanic adults who smoke and want to quit. Participants will use the iCanQuit smartphone app, which teaches skills to manage cravings and prevent relapse. Half will also receive nicotine replacement therapy (gum, patch, or lozenge) to ease wi…

This study tests whether giving a lower dose of the immunotherapy drug nivolumab less often can still control advanced cancers that have spread or cannot be removed. About 50 adults with various cancers (like melanoma, lung, or kidney cancer) will receive the treatment. The goal …

This study will see if adding a remote nurse via telehealth to pharmacy-based HIV prevention services helps more people start and continue taking PrEP or PEP. About 1,580 pharmacy clients in Kenya will be assigned to either standard pharmacy care or care with extra telehealth sup…

This study tests whether using two heat probes instead of one can better prevent cervical cancer in women living with HIV, who face a much higher risk. Researchers will enroll 300 women in Kenya to see if the two-probe method is safe, acceptable, and more effective at clearing HP…

This study will test if using two heat probes instead of one can better prevent cervical cancer in 300 women with HIV in Zimbabwe. The standard single-probe treatment often fails in these women. The goal is to see if the two-probe method is safe, acceptable, and more effective at…

This study tests whether using two probes during a heat-based treatment (thermal ablation) works better than the usual one-probe method to prevent cervical cancer in women living with HIV. About 200 women aged 25-49 with HIV and cervical precancer will be enrolled. The goal is to…

This study will test if using two probes during a procedure called thermal ablation works better than the usual one-probe method to prevent cervical cancer in women living with HIV. The study will involve 300 women in Rwanda who have HIV and signs of early cervical changes. The g…

This study looks at whether training pharmacy staff to better communicate about and manage the HPV vaccine can increase vaccination rates in children ages 9-17. About 1,900 participants, including pharmacy staff and parents, will be involved. The goal is to make it easier for fam…

This study tests a spiritual health program called PATH for cancer patients struggling with feelings of disconnection, loss of meaning, or existential distress. Twenty adults with any stage of cancer will attend six workshops combining role-playing, psychology, and dignity therap…

This study tests whether an online nutrition education website, Cook for Your Life, can help breast cancer patients manage side effects like diarrhea and constipation during chemotherapy. About 50 adults with stage I-III breast cancer will use the website alongside standard care.…

This pilot study tests whether giving early-stage cancer patients a monthly cash card (no restrictions on use) can reduce financial hardship and improve their well-being. Researchers will enroll 20 adults recently diagnosed with early-stage solid tumors who have financial concern…

This study tests if eating only within an 8-hour window each day (time-restricted eating) can reduce treatment side effects and improve quality of life for people with solid tumors starting adjuvant therapy after surgery. Fifty adults will be randomly assigned to follow this eati…

This study tests a decision-making tool based on restorative justice to help Black adults aged 50-77 with a smoking history decide about lung cancer screening. The goal is to see if this approach increases screening rates and addresses mistrust. About 45 participants will try the…

This study tests whether personalized patient navigation can help more American Indian and Alaska Native people in Washington state get screened for lung cancer. About 237 adults aged 50-77 who smoke or recently quit will be enrolled. The goal is to see if tailored support helps …

This clinical trial evaluates the acceptability and effectiveness of an educational intervention (Lung Toolkit) for improving knowledge about lung cancer and lung cancer screening among American Indian/Alaskan Native (AI/AN) cigarette smokers. The Lung Toolkit is an educational i…