Fred Hutchinson Cancer Center

This study looks at children and teens with HIV to find the best number of HPV vaccine doses. Researchers are comparing one, two, or three doses to see if fewer shots can still provide strong protection against HPV. The goal is to simplify vaccination and improve health outcomes …

This pilot study tests a remotely-delivered nutrition and cooking program called MIND for stage I-III breast cancer survivors. The program is delivered online through the Cook for Your Life platform and aims to improve diet quality. The study will enroll 49 participants to see if…

This study tests whether giving the drug ruxolitinib before, during, and after a donor stem cell transplant can prevent graft-versus-host disease (GVHD) in people with myelofibrosis. GVHD is a serious complication where donor cells attack the patient's body. The trial involves 53…

This study tests two types of telephone coaching to help overweight or obese adults lose weight. One method focuses on accepting cravings while making healthy choices, and the other uses standard behavior change techniques. About 418 participants will receive coaching over the ph…

This study tests a treatment made from a patient's own immune cells, which are genetically modified to recognize and attack a protein called CD20 on cancer cells. It is for people with B-cell non-Hodgkin lymphoma that has returned or not responded to prior therapy. The main goals…

This phase 3 trial tests a smartphone app called Quit2Heal designed to help cancer patients stop smoking. 427 participants will use either Quit2Heal or a standard quit-smoking app. The goal is to see if the specialized app leads to more people quitting for at least 30 days after …

This phase II trial tests two different chemotherapy combinations (treosulfan-based vs. clofarabine-based) given before a donor stem cell transplant in adults with myelodysplastic syndromes or acute myeloid leukemia. The goal is to see which regimen leads to better relapse-free s…

This phase II trial tests whether the drug ustekinumab (Stelara) can prevent acute graft-versus-host disease (GVHD) in 116 adults receiving stem cell transplants for blood cancers. GVHD occurs when donor immune cells attack the patient's body. Ustekinumab aims to calm this immune…

This study tests whether adding ruxolitinib to standard care can prevent graft-versus-host disease (GVHD) in older adults with aplastic anemia who receive a stem cell transplant. GVHD is a serious complication where donor cells attack the patient's body. The trial involves one pa…

This early-stage trial tests whether adding an experimental drug called NKTR-255 to standard CAR-T cell therapy can safely improve outcomes for adults with large B-cell lymphoma that has returned or stopped responding to treatment. The drug is designed to strengthen the immune sy…

This study tests whether giving full-strength chemotherapy (either CPX-351 or a combination called CLAG-M) can help medically less-fit adults with acute myeloid leukemia live longer and achieve remission. About 60 participants will receive one of the two treatments. The goal is t…

This early-stage trial tests a new targeted drug called pivekimab sunirine (PVEK) combined with standard chemotherapy for adults with aggressive acute myeloid leukemia (AML) and related blood cancers. PVEK works like a smart bomb, attaching to cancer cells and delivering chemo di…

This study tests a drug called acalabrutinib in 51 adults with moderate to severe chronic graft-versus-host disease (GVHD), a complication after a stem cell transplant. The goal is to see if the drug can control the disease when steroids have stopped working. Participants take th…

This study tests a strong chemotherapy combination followed by a stem cell transplant in 53 people with autoimmune neurologic diseases (like multiple sclerosis or stiff person syndrome) that did not improve with standard treatments. The goal is to weaken the overactive immune sys…

This study looks at different methods to find early signs of cervical cancer in women living with HIV in the Dominican Republic. The goal is to see which screening approach works best to catch abnormal cells caused by HPV. About 619 women aged 25-49 will take part, helping doctor…

This study tests whether giving patients a transplant of healthy gut bacteria (from donated stool) can prevent severe graft-versus-host disease (GVHD) after a stem cell transplant. GVHD is a serious complication where donor immune cells attack the patient's body. The trial involv…

This study tests a program designed to help men who have sex with men in Lima, Peru get tested for HIV and connect to treatment or prevention services. The program offers HIV testing at social venues and provides a text-messaging app with health information and support from a hea…

This study aimed to test a smartphone app called EQQUAL-NM, designed to help sexual and gender minority young adults (ages 18–30) in New Mexico quit smoking. The app used a culturally-tailored avatar to deliver support. However, the trial was withdrawn before any participants enr…

This study tests a program called HOPE (Helping Ovarian Cancer Patients Cope with Their Disease) to see if it can reduce feelings of hopelessness and helplessness in patients whose ovarian cancer has returned. About 60 adults with recurrent ovarian cancer will either take part in…

This trial tests whether adding care coordination services—like patient navigation and direct communication—can improve how often people get the recommended follow-up after a lung cancer screening. It involves over 6,700 participants across community clinics. The goal is to see i…

This study involves 383 people who have chronic graft-versus-host disease (GVHD) after a stem cell transplant. Researchers are developing and testing new ways to measure whether a treatment is working, including a symptom-based activity index and a score that predicts long-term s…

This study looks at inherited gene changes (like BRCA) in men with prostate cancer to understand how common they are and how they affect treatment. Researchers will collect saliva samples and health information from 1,360 men in Washington state. The goal is to improve cancer car…

This study looks at whether new guidelines from the National Institutes of Health can help doctors better diagnose and track chronic graft-versus-host disease (GVHD), a common complication after stem cell transplants. Researchers are following 601 patients over several years, col…

This study tests whether personalized coaching and mobile apps can help cancer survivors become more physically active and improve their diet. About 374 adult survivors of childhood or young adult cancers will participate. The goal is to see if these programs lead to lasting heal…