New drug may spare transplant patients from lifelong immune suppression

NCT ID NCT05996627

Recruiting now Disease control Sponsor: Fred Hutchinson Cancer Center Source: ClinicalTrials.gov ↗

First seen Nov 01, 2025 · Last updated May 01, 2026 · Updated 21 times

Summary

This study tests whether the drug belumosudil can prevent chronic graft-versus-host disease (cGVHD), a common complication after stem cell transplants where the donor's immune cells attack the patient's body. About 82 participants will receive either belumosudil or a placebo. The goal is to see if the drug can delay or avoid the need for additional immune-suppressing medications, which often have serious side effects.

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Study contacts

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Locations

Dana-Farber Cancer Institute
RECRUITING

Boston, Massachusetts, 02215, United States

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Fred Hutch/University of Washington Cancer Consortium
RECRUITING

Seattle, Washington, 98109, United States

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Memorial Sloan Kettering Cancer Center
RECRUITING

New York, New York, 10065, United States

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Moffitt Cancer Center
RECRUITING

Tampa, Florida, 33612, United States

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Conditions

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CHRONIC GRAFT VERSUS HOST DISEASE