CHRONIC GRAFT VERSUS HOST DISEASE

This study is testing a drug called belumosudil to see if it can help control a serious lung scarring condition called bronchiolitis obliterans syndrome (BOS). BOS can develop in people who have received a donor stem cell transplant. The trial will enroll 45 adults who have eithe…

This study is testing whether adding a new drug called axatilimab to an existing drug (ruxolitinib) works better for controlling chronic Graft-Versus-Host Disease (cGVHD). It will involve about 120 people who have recently been diagnosed with moderate or severe cGVHD after a stem…

This early-stage study is testing a new drug called Q702 in patients with chronic graft-versus-host disease that hasn't improved with standard treatments. The research aims to find the safest dose and understand how the drug works in the body. Participants will have moderate to s…

This study aims to understand if crushing belumosudil tablets changes how the drug is absorbed in the body compared to swallowing them whole. It involves 8 adult patients who have chronic graft-versus-host disease after a stem cell transplant. Researchers will measure drug levels…

This early-stage study is testing whether adding fostamatinib to the standard drug ruxolitinib is safe and effective for chronic graft-versus-host disease that doesn't respond well to steroid treatment. The trial will enroll about 30 adults who have had a stem cell transplant and…

This study is testing a drug called belumosudil in children aged 1 to 18 who have a serious condition called chronic graft-versus-host disease (cGVHD) after a bone marrow transplant. The goal is to find the right dose for younger children and see if the drug is safe and can help …

This study is testing an experimental drug called axatilimab for Chinese patients with chronic graft-versus-host disease (cGVHD) that has returned or hasn't improved with standard treatments. cGVHD is a serious complication that can occur after a stem cell transplant, where the d…

This study is testing whether adding a new drug called axatilimab to standard steroid treatment works better than steroids alone for people with moderate to severe chronic graft-versus-host disease (cGVHD). cGVHD is a serious complication where the donor's immune cells attack the…

This study is testing whether a new drug called axatilimab works better than current standard treatments for children with chronic graft-versus-host disease (cGVHD) who haven't responded to at least two previous therapies. The trial will involve 60 children aged 2 to 18 years who…

This study is testing a drug called axatilimab for people who develop thick, hard skin after a donor stem cell transplant, a condition called sclerotic chronic graft-versus-host disease (cGVHD). The drug is an antibody given by IV that aims to block cells involved in the scarring…

This study aims to collect long-term safety and effectiveness data for patients with various blood cancers who are already taking the drug ibrutinib and benefiting from it. It provides continued access to the medication for about 700 participants who were in previous ibrutinib st…

This study is testing a two-drug combination (belumosudil and rituximab) as the first treatment for people who develop extensive chronic graft-versus-host disease after a bone marrow transplant. The trial will enroll 25 patients who haven't received previous treatment for this co…

This study is testing whether the drug belumosudil can help control chronic graft-versus-host disease (cGVHD), a serious complication where the donor's immune cells attack the patient's body after a stem cell transplant. The trial will enroll 82 adult patients who have early sign…

This study is testing if a drug called ibrutinib can prevent chronic graft-versus-host disease (GVHD) in patients who have received a donor stem cell transplant. GVHD is a serious condition where the donor's immune cells attack the patient's body. The trial will enroll 40 adults …

This study is testing if a home-based exercise program can help patients who develop Graft-Versus-Host Disease (GVHD) after a stem cell transplant. The goal is to see if exercise can improve blood sugar control, body composition, fitness, and quality of life while patients are on…

This study aims to help doctors predict how patients with chronic graft-versus-host disease (cGVHD) will respond to new treatments. Researchers will collect blood samples and survey data from 300 adult patients before and after they start new therapies. The goal is to identify pa…