CHRONIC GRAFT VERSUS HOST DISEASE

This study gives continued access to the drug itacitinib for people who were already taking it in a previous study and were doing well. It includes patients with myelofibrosis, chronic graft-versus-host disease, or bronchiolitis obliterans after a lung transplant. The goal is to …

This study tests whether adding belumosudil to standard steroid treatment helps control chronic graft-versus-host disease (cGVHD), a complication after stem cell transplant. About 260 people aged 12 and older with newly diagnosed moderate to severe cGVHD will receive either the d…

This early-stage trial tests a new treatment called CD6-CAR Tregs for people with chronic graft-versus-host disease (cGVHD), a complication after stem cell transplants. The treatment uses specially engineered immune cells from a donor to help control the immune attack on the pati…

This study tests a drug called axatilimab against the best available treatments for people with chronic graft-versus-host disease (cGVHD) who have already tried at least two other therapies. cGVHD is a complication after a stem cell transplant where the donor cells attack the pat…

This study tests a new tablet, TQ05105, for people with moderate to severe chronic graft-versus-host disease (cGVHD) that doesn't get better with steroids. The trial includes 45 adults who have had a stem cell transplant. The goal is to find the best dose and see if the drug can …

This study aimed to test the safety and effectiveness of the oral drug belumosudil in Black, American Indian, Alaska Native, Native Hawaiian, and other Pacific Islander people aged 12 and older with chronic graft-versus-host disease (cGVHD) who had already tried at least two othe…

This study tests a new oral drug called alvelestat in people who developed a serious lung condition (bronchiolitis obliterans syndrome) after a stem cell transplant. The drug aims to block a harmful enzyme that may cause lung damage. Researchers will check safety, find the best d…

This study tested whether a daily low-dose injection of IL-2 can help control chronic graft-versus-host disease (cGVHD) in 35 people who had not improved with steroids. cGVHD is a condition where donor immune cells attack the recipient's body after a stem cell or bone marrow tran…

This study tests a drug called axatilimab in people with chronic graft-versus-host disease (cGVHD), a complication after a stem cell transplant where the donor cells attack the patient's body. Participants must have tried at least two other treatments without success. The goal is…

This study tests a drug called axatilimab in Japanese patients with chronic graft-versus-host disease (cGVHD) that has not responded to at least two prior treatments. cGVHD is a serious complication after a stem cell transplant where the donor cells attack the patient's body. The…

This early-stage trial tests a combination of donor immune cells (Tregs) and a low-dose protein (IL-2) to control chronic graft-versus-host disease (cGVHD), a condition where donor cells attack the recipient's body after a stem cell transplant. The study includes 25 people whose …

This study looks at whether a mobile app called Horizons can help adults who have chronic graft-versus-host disease after a stem cell transplant. About 20 people will use the app and answer surveys to see if it is practical and helpful. The goal is to improve their quality of lif…

This study looks at whether a telehealth palliative care program is practical and well-liked by people with moderate to severe chronic graft-versus-host disease (cGVHD), a complication after a stem cell transplant. Ten adults will receive three video-based support sessions. The g…

This study tests a mobile app called Horizons designed to help people with chronic graft-versus-host disease (GVHD) cope better and improve their quality of life. About 120 adults who had a stem cell transplant and now have moderate to severe chronic GVHD will use the app or rece…

This study looks at whether new guidelines from the National Institutes of Health can help doctors better understand and track chronic graft-versus-host disease (GVHD), a complication after stem cell transplants. Researchers are following 601 patients over several years, collecti…

This study looks at how different types of immune cells (dendritic cells) in the skin are involved in graft-versus-host disease (GVHD) after a bone marrow transplant. Researchers will collect skin samples and blood from 22 adults with acute or chronic skin GVHD to analyze cell ty…